The Future of ApoB: Moving from the Risk Prediction Paradigm to the Causal Exposure Paradigm

  • Jacqueline de Graaf
  • Patrick Couture
  • Allan D. Sniderman


Words matter. The words we choose to represent our beliefs govern how we act. Accordingly, the objective of this final chapter is to argue that we should change our language so that we will change our actions. The Risk Prediction Paradigm presently governs prevention of vascular disease. However, we believe prevention would be much more successful if we moved to the Causal Exposure Paradigm, which is simpler, more direct, and calls for earlier therapeutic intervention than the Risk Prediction Paradigm.231,248,249


Clinical Event Primary Prevention Statin Therapy Absolute Benefit Calculated Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Media BV, Houten, The Netherlands 2015

Authors and Affiliations

  • Jacqueline de Graaf
    • 1
  • Patrick Couture
    • 2
  • Allan D. Sniderman
    • 3
  1. 1.Department of Internal MedicineRadboud university medical centerNijmegenThe Netherlands
  2. 2.Lipid Research CentreLaval University Medical CenterQuebec CityCanada
  3. 3.Mike Rosenbloom Laboratory for Cardiovascular ResearchMcGill University Health CentreMontrealCanada

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