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Nierinsufficiëntie en medicatie

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Inzichten in de nefrologie

Samenvatting

In de huisartsenpraktijk neemt het aantal patiënten met een verminderde nierfunctie toe. Veel geneesmiddelen worden renaal uitgescheiden, wat onder andere consequenties heeft voor de dosering van deze geneesmiddelen. Het is in de dagelijkse praktijk niet altijd gemakkelijk hiermee om te gaan. In dit hoofdstuk gaan we dieper in op de beoordeling van de nierfunctie en geven we vervolgens achtergrondinformatie en praktische adviezen omtrent het gebruik van antibiotica, orale antidiabetica, ACE-remmers, NSAID’s, diuretica en de nieuwe directe orale anticoagulantia (DOAC) bij nierinsufficiëntie.

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Literatuur

  1. Harm-rapport (Hospital Admissions Related to Medication). Utrecht: Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology & Pharmacotherapy, November 2006.

    Google Scholar 

  2. Leendertse AJ, Dijk EA van, Smet PA de, Egberts TC, Bemt PM van den. Contribution of renal impairment to potentially preventable medication-related hospital admissions. Ann Pharmacother. 2012 May;46(5):625–33.

    Article  PubMed  Google Scholar 

  3. Froissart M, Rossert J, Jacquot C, Paillard M, Houillier P. Predictive performance of the modification of diet in renal disease and Cockroft-Gault equations for estimating renal function. J Am Soc Nephrol. 2005;16:763–73.

    Article  PubMed  Google Scholar 

  4. Verhave JC, Kramers C, Wetzels JFM. Nieuwe formule leidt tot betere schattingen. Pharm Weekbl. 2007;142(40):18–21.

    Google Scholar 

  5. Felts JH, Hayes DM, Gergen JA, Toole JF. Neural, hematologic and bacteriologic effects of nitrofurantoin in renal insufficiency. Am J Med. 1971;51:331–9.

    Article  CAS  PubMed  Google Scholar 

  6. Thieler H, Meyer W. Nil nocere! Severe polyneuropathy during nitrofurantoin therapy of renal insufficiency. Dtsch Gesundheitsw. 1968;23:488–91.

    CAS  PubMed  Google Scholar 

  7. Geerts AF, et al. Ineffectiveness and adverse events of nitrofurantoin in women with urinary tract infection and renal impairment in primary care. Eur J Clin Pharmacol. 2013 Sep;69(9):1701–7.

    Article  CAS  PubMed  Google Scholar 

  8. Siber GR, Gorham CC, Ericson JF, Smith AL. Pharmacokinetics of intravenous trimethoprim-sulfamethoxazole in children and adults with normal and impaired renal function. Rev Infect Dis. 1982 Mar-Apr;4(2):566–78.

    Article  CAS  PubMed  Google Scholar 

  9. Rigalleau V, et al. Estimation of renal function in patients with diabetes. Diabetes Metab. 2011;37(5):359–66.

    Article  CAS  PubMed  Google Scholar 

  10. Linden CMJ van der, Knol W, Marum RJ van, Jansen PA. Lactaatacidose bij een 85-jarige vrouw door behandeling met metformine. Ned Tijdschr Geneeskd. 2007;151:977–80.

    PubMed  Google Scholar 

  11. Howlett HC, Bailey CJ. A risk-benefit assessment of metformin in type 2 diabetes mellitus. Drug Saf. 1999:489–503.

    Google Scholar 

  12. Graham GG, et al. Clinical pharmacokinetics of metformin. Clin Pharmacokinet. 2011;50 (2):81-98.

    Article  CAS  PubMed  Google Scholar 

  13. Jönsson A, Rydberg T, Sterner G, Melander A. Pharmacokinetics of glibenclamide and its metabolites in diabetic patients with impaired renal function. Eur J Clin Pharmacol. 1998;53:429–35.

    Article  PubMed  Google Scholar 

  14. Rosenkranz B, Profozic V, Metelko Z, Mrzljak V, Lange C, Malerczyk V. Pharmacokinetics and safety of glimepiride at clinically effective doses in diabetic patients with renal impairment. Diabetologia. 1996;39:1617–24.

    Article  CAS  PubMed  Google Scholar 

  15. Marbury TC, et al. Pharmacokinetics of repaglinide in subjects with renal impairment. Clin Pharmacol Ther. 2000 Jan;67(1):7–15.

    Article  CAS  PubMed  Google Scholar 

  16. Lam FYW, Banerji S, Hatfield C, Talbert RL. Principles of drug administration in renal insufficiency. Clin Pharmocokinet. 1997 Jan;32 (1):30–57.

    Google Scholar 

  17. Boulton D, et al. Influence of renal or hepatic impairment on the pharmacokinetics of saxagliptin. Clin Pharmacokinet. 2011 Apr;50(4):253–65.

    Article  CAS  PubMed  Google Scholar 

  18. Lukashevich V, Schweizer A, Shao Q, Groop PH, Kothny W. Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled trial. Diabetes Obes Metab. 2011;13:947–54.

    Article  CAS  PubMed  Google Scholar 

  19. Bergman AJ, et al. Effect of renal insufficiency on the pharmacokinetics of sitagliptin, a dipeptidyl peptidase-4 inhibitor. Diabetes Care 2007;30:1862–4.

    Article  CAS  PubMed  Google Scholar 

  20. Linneberg H, et al. Effect of renal impairment on the pharmacokinetics of exenatide. Br J Clin Pharmacol. 2007;64:317–27.

    Article  Google Scholar 

  21. Jacobsen LV, Hindsberger C, Robson R, Zdravkovic M. Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide. Br J Clin Pharmacol. 2009 Dec;68(6):898–905.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Bootsma JE, et al. Adherence to biochemical monitoring recommendations in patients starting with renin angiotensin system inhibitors: a retrospective cohort study in the Netherlands. Drug Saf. 2011 Jul 1;34(7):605–14.

    Article  PubMed  Google Scholar 

  23. Whelton A. Nephrotoxicity of nonsteroidal anti-inflammatory drugs: physiologic foundations and clinical implications. Am J Med. 1999 May 31;106(5B):13S–24S.

    Google Scholar 

  24. Clive DM, Stoff JS. Renal syndromes associated with nonsteroidal anti-inflammatory drugs. New Engl J Med. 1984;310:563–72.

    Article  CAS  PubMed  Google Scholar 

  25. Niemeyer C, Hasenfuss G, Wais U, Knauf H, Schäfer-Korting M, Mutschler E. Pharmacokinetics of hydrochloorthiazide in relation to renal function. Eur J Clin Pharmacol. 1983;24:661–5.

    Article  CAS  PubMed  Google Scholar 

  26. Traeger A, et al. Pharmacokinetic and pharmacodynamic effects of furosemide in patients with impaired renal function. Int J Clin Pharmacol Ther Toxicol. 1984;22(9):481–6.

    CAS  PubMed  Google Scholar 

  27. Syropoulus AC, Douketis JD. How I treat anticoagulated patients undergoing an elective procedure or surgery. Blood 2012;120(15):2954–62.

    Article  Google Scholar 

  28. Steffel J, Hindrick G. Apixaban in renal insufficiency: successful navigation between the Scylla and Charybdis. Eur Heart J. 2012;33:2766–8.

    Article  CAS  PubMed  Google Scholar 

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Esselink, A., Scherpbier-de Haan, N., Kramers, K. (2014). Nierinsufficiëntie en medicatie. In: van den Bosch, W., Wetzels, J. (eds) Inzichten in de nefrologie. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0838-5_5

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  • DOI: https://doi.org/10.1007/978-90-368-0838-5_5

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