Samenvatting
In Nederland zijn verschillende mondgels, -sprays en -spoelmiddelen beschikbaar ter verlichting van monddroogte. In een literatuuronderzoek werd gezocht naar wetenschappelijke onderzoeken naar de effectiviteit van deze middelen. Vervolgens werd het gebruik van speekselsubstituten door sjögrenpatiënten onderzocht.
Speekselsubstituten zouden bij patiënten verlichting van monddroogteklachten moeten geven. Op grond van de tot nu toe gepubliceerde onderzoeken lijkt de wetenschappelijke onderbouwing voor de werkzaamheid van speekselsubstituten beperkt. Enkele middelen lijken een, relatief beperkt, positief effect te hebben op de monddroogte. Patiënten stoppen vaak met het gebruik van speekselsubstituten, omdat zij het effect als te gering ervaren en de smaak van de producten tekortschiet.
Geconcludeerd mag worden dat er behoefte is aan de ontwikkeling van meer effectieve speekselsubstituten, waarbij de verschillende doelgroepen met monddroogte nauw betrokken dienen te worden.
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Literatuur
Blixt-Johansen G, Ek AC, Ganowiak W, Granérus AK, von Schenck H, Unosson M, Wiesel K. Improvement of oral mucosa with mucin containing artificial saliva in geriatric patients. Arch Gerontol Geriatr. 1992;14:193–201.
Bots CP, Brand HS, Veerman ECI, et al. Chewing gum and a saliva substitute alleviate thirst and xerostomia in patients on haemodialysis. Nephrol Dial Transplant. 2005 Mar; 20(3):578–84.
Brand HS, Ouzzine R, Bots CP. Sticky saliva products. Br Dent J. 2013;214:95.
Davies AN. A comparison of artificial saliva and chewing gum in the management of xerostomia in patients with advanced cancer. Palliat Med. 2000;14:197–203.
Duxbury AJ, Thakker NS, Wastell DG. A double-blind cross-over trial of a mucin-containing artificial saliva. Br Dent J. 1989;166:115–20.
Epstein JB, Emerton S, Le ND, Stevenson-Moore P. A double-blind crossover trial of Oral Balance gel and Biotene toothpaste versus placebo in patients with xerostomia following radiation therapy. Oral Oncol. 1999;35:132–7.
Frost PM, Shirlaw PJ, Walter JD, Challacombe SJ. Patient preferences in a preliminary study comparing an intra-oral lubricating device with the usual dry mouth lubricating methods. Br Dent J. 2002;193:403–8.
Gil-Montoya JA, Guardia-López I, González-Moles MA. Evaluation of the clinical efficacy of a mouthwash and oral gel containing the antimicrobial proteins lactoperoxidase, lysozyme and lactoferrin in elderly patients with dry mouth – a pilot study. Gerodontology. 2008;25:3–9.
Gómez-Moreno G, Aguilar-Salvatierra A, Guardia J, Uribe-Marioni A, Cabrera-Ayala M, Delgado-Ruiz RA, Calvo-Guirado JL. The efficacy of a topical sialogogue spray containing 1% malic acid in patients with antidepressant-induced dry mouth: a double-blind, randomized clinical trial. Depress Anxiety. 2013a;30:137–42.
Gómez-Moreno G, Cabrera-Ayala M, Aguilar-Salvatierra A, Guardia J, Ramírez-Fernández MP, González-Jaranay M, Calvo-Guirado JL. Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial. Gerodontology. 2013b [Epub ahead of print.]
Jellema AP, Langendijk H, Bergenhenegouwen L, Reijden W van der, Leemans R, Smeele L, Slotman BJ. The efficacy of Xialine in patients with xerostomia resulting from radiotherapy for head and neck cancer: a pilot-study. Radiother Oncol. 2001;59:157–60.
McMillan AS, Tsang CS, Wong MC, Kam AY. Efficacy of a novel lubricating system in the management of radiotherapy-related xerostomia. Oral Oncol. 2006;42:842–8.
Momm F, Volegova-Neher NJ, Schulte-Mönting J, Guttenberger R. Different saliva substitutes for treatment of xerostomia following radiotherapy. A prospective crossover study. Strahlenther Onkol. 2005;181:231–6.
Nagy K, Urban E, Fazekas O, Thurzo L, Nagy E. Controlled study of lactoperoxidase gel on oral flora and saliva in irradiated patients with oral cancer. J Craniofac Surg. 2007;18:1157–64.
Reijden WA van der, Kwaak H van der, Vissink A, Veerman EC, Amerongen AV. Treatment of xerostomia with polymer-based saliva substitutes in patients with Sjögren’s syndrome. Arthritis Rheum. 1996;39:57–63.
Robinson PG, Pankhurst CL, Garrett EJ. Randomized-controlled trial: effect of a reservoir biteguard on quality of life in xerostomia. J Oral Pathol Med. 2005;34:193–7.
Shahdad SA, Taylor C, Barclay SC, Steen IN, Preshaw PM. A double-blind, crossover study of Biotène Oralbalance and BioXtra systems as salivary substitutes in patients with post-radiotherapy xerostomia. Eur J Cancer Care (Engl). 2005;14:319–26.
Sweeney MP, Bagg J, Baxter WP, Aitchison TC. Clinical trial of a mucin-containing oral spray for treatment of xerostomia in hospice patients. Palliat Med. 1997;11:225–32.
Thomson WM, Chalmers JM, Spencer AJ, Williams SM. The Xerostomia Inventory: a multi-item approach to measuring dry mouth. Community Dent Health. 1999;16:12–7.
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Bots, C., Ouzzine, R., Brand, H. (2014). Effectiviteit van speekselsubstituten ter verlichting van monddroogte. In: Aps, J., Brand, H., De Bruyne, M., van Es, R., Jacobs, R., Vissink, A. (eds) Het tandheelkundig jaar 2015. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0689-3_1
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