Abstract
Neuromyelitis optica (NMO) is an immune-mediated condition of the CNS preferentially involving spinal cord and optic nerves. Serum autoantibodies targeting aquaporin-4 (AQP4) are diagnostic markers of NMO.
Within 5 years from onset, 50 % of patients with relapsing NMO are blind in one or both eyes, and/or need assistance to walk, and/or use a wheelchair.
Most patients with AQP4-IgG positive NMO have a severe, relapsing course.
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Filippini, G. (2015). Myelin Disorders: Devic’s Syndrome. In: Sghirlanzoni, A., Lauria, G., Chiapparini, L. (eds) Prognosis of Neurological Diseases. Springer, Milano. https://doi.org/10.1007/978-88-470-5755-5_12
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DOI: https://doi.org/10.1007/978-88-470-5755-5_12
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