Skip to main content
SpringerLink
Log in

Integrated Cardiac Imaging

  • Chapter
Diseases of the Chest and Heart 2015–2018

  • 1250 Accesses

Abstract

Noninvasive cardiac imaging has evolved substantially over the past few years. New reconstruction algorithms and a new generation of y-cameras with cadmiumzinc telluride (CZT) semiconductor detectors have shortened scan time and improved image quality in myocardial perfusion imaging (MPI) by single photon emission computed tomography (SPECT). In addition, technical refinements in coronary computed tomography angiography (CCTA) have led to a substantial dose reduction while image quality has improved. However, invasive coronary angiography has remained the anatomic standard of reference even though it is associated with a nonnegligible perioperative morbidity and mortality that suggests confining its use to patients who will benefit from a subsequent revascularization procedure. The poor agreement between the severity of coronary artery stenosis (morphological assessment) and the hemodynamical relevance of the stenosis (functional assessment) has been shown; thus, the coronary anatomy rarely allows estimation of the patho-physiologic relevance of a coronary lesion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Flotats A, Knuuti J, Gutberlet M et al (2011) Hybrid cardiac imaging: SPECT/CT and PET/CT. A joint position statement by the European Association of Nuclear Medicine (EANM), the European Society of Cardiac Radiology (ESCR) and the European Council of Nuclear Cardiology (ECNC). Eur J Nucl Med Mol Imaging 38:201–212.

    Article  PubMed  Google Scholar 

  2. Dorbala S, Di Carli MF, Delbeke D et al (2013) SNMMI/AS-NC/SCCT guideline for cardiac SPECT/CT and PET/CT 1.0. J Nucl Med 54:1485–1507.

    Article  PubMed  Google Scholar 

  3. Hodler J, Schulthess GK, Zollikofer CL (2011) Diseases of the Heart, Chest & Breast. Diagnostic Imaging and Interventional Techniques. Springer, pp 199–202.

    Google Scholar 

  4. Achenbach S, Daniel WG (2001) Noninvasive coronary angiography—an acceptable alternative? N Engl J Med 345:1909–1910.

    Article  CAS  PubMed  Google Scholar 

  5. Shaw LJ, Shaw RE, Merz CN et al (2008) Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology-National Cardiovascular Data Registry. Circulation 117:1787–1801.

    Article  PubMed  Google Scholar 

  6. White CW, Wright CB, Doty DB et al (1984) Does visual interpretation of the coronary arteriogram predict the physiologic importance of a coronary stenosis? N Engl J Med 310:819–824.

    Article  CAS  PubMed  Google Scholar 

  7. Uren NG, Melin JA, De Bruyne B et al (1994) Relation between myocardial blood flow and the severity of coronaryartery stenosis. N Engl J Med 330:1782–1788.

    Article  CAS  PubMed  Google Scholar 

  8. Patel MR, Peterson ED, Dai D et al (2010) Low diagnostic yield of elective coronary angiography. N Engl J Med 362:886–895.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Cheng VY, Berman DS, Rozanski A et al (2011) Performance of the traditional age, sex, and angina typicality-based approach for estimating pretest probability of angiographically significant coronary artery disease in patients undergoing coronary computed tomographic angiography: results from the multinational coronary CT angiography evaluation for clinical outcomes: an international multicenter registry (CONFIRM). Circulation 124:2423–2432, 2421–2428.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Bartunek J, Sys SU, Heyndrickx GR et al (1995) Quantitative coronary angiography in predicting functional significance of stenoses in an unselected patient cohort. J Am Coll Cardiol 26:328–334.

    Article  CAS  PubMed  Google Scholar 

  11. Windecker S, Kolh P, Alfonso F et al (2014) 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS) Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). EuroIntervention [Epub ahead of print].

    Google Scholar 

  12. Budoff MJ, Dowe D, Jollis JG et al (2008) Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial. J Am Coll Cardiol 52:1724–1732.

    Article  PubMed  Google Scholar 

  13. Buechel RR, Husmann L, Herzog BA et al (2011) Low-dose computed tomography coronary angiography with prospective electrocardiogram triggering: feasibility in a large population. J Am Coll Cardiol 57:332–336.

    Article  PubMed  Google Scholar 

  14. Achenbach S, Marwan M, Ropers D et al (2010) Coronary computed tomography angiography with a consistent dose below 1 mSv using prospectively electrocardiogram-triggered high-pitch spiral acquisition. Eur Heart J 31:340–346.

    Article  PubMed  Google Scholar 

  15. Fuchs TA, Stehli J, Bull S et al (2014) Coronary computed tomography angiography with model-based iterative reconstruction using a radiation exposure similar to chest X-ray examination. Eur Heart J 35:1131–1136.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Underwood SR, Anagnostopoulos C, Cerqueira M et al (2004) Myocardial perfusion scintigraphy: the evidence. Eur J Nucl Med Mol Imaging 31:261–291.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Tonino PA, Fearon WF, De Bruyne B et al (2010) Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation. J Am Coll Cardiol 55:2816–2821.

    Article  PubMed  Google Scholar 

  18. Kapur A, Latus KA, Davies G et al (2002), A comparison of three radionuclide myocardial perfusion tracers in clinical practice: the ROBUST study. Eur J Nucl Med Mol Imaging 29:1608–1616.

    Article  CAS  PubMed  Google Scholar 

  19. Buechel RR, Pazhenkottil AP, Herzog BA et al (2010) Real-time breath-hold triggering of myocardial perfusion imaging with a novel cadmiumzinc-telluride detector gamma camera. Eur J Nucl Med Mol Imaging 37:1903–1908.

    Article  PubMed  Google Scholar 

  20. Fiechter M, Ghadri JR, Kuest SM et al (2011) Nuclear myocardial perfusion imaging with a novel cadmiumzinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography. Eur J Nucl Med Mol Imaging 38:2025–2030.

    Article  CAS  PubMed  Google Scholar 

  21. Herzog BA, Buechel RR, Katz R et al (2010) Nuclear myocardial perfusion imaging with a cadmiumzinc-telluride detector technique: optimized protocol for scan time reduction. J Nucl Med 51:46–51.

    Article  PubMed  Google Scholar 

  22. Namdar M, Hany TF, Koepfli P et al (2005) Integrated PET/CT for the assessment of coronary artery disease: a feasibility study. J Nucl Med 46:930–935.

    PubMed  Google Scholar 

  23. Gaemperli O, Kaufmann PA. (2008), Hybrid cardiac imaging: more than the sum of its parts? J Nucl Cardiol 15:123–126.

    Article  PubMed  Google Scholar 

  24. Gaemperli O, Schepis T, Valenta I et al (2007) Cardiac image fusion from stand-alone SPECT and CT: clinical experience. J Nucl Med 48:696–703.

    Article  PubMed  Google Scholar 

  25. Fiechter M, Ghadri JR, Wolfrum M et al (2012) Downstream resource utilization following hybrid cardiac imaging with an integrated cadmiumzinc-telluride/64-slice CT device. Eur J Nucl Med Mol Imaging 39:430–436.

    Article  PubMed  Google Scholar 

  26. Hachamovitch R, Hayes SW, Friedman JD et al (2003) Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography. Circulation 107:2900–2907.

    Article  PubMed  Google Scholar 

  27. Shaw LJ, Berman DS, Maron DJ et al (2008) Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial nuclear substudy. Circulation 117:1283–1291.

    Article  PubMed  Google Scholar 

  28. Gaemperli O, Schepis T, Valenta I et al (2008) Functionally relevant coronary artery disease: comparison of 64-section CT angiography with myocardial perfusion SPECT. Radiology 248:414–423.

    Article  PubMed  Google Scholar 

  29. van Werkhoven JM, Schuijf JD, Gaemperli O et al (2009) Prognostic value of multislice computed tomography and gated single-photon emission computed tomography in patients with suspected coronary artery disease. J Am Coll Cardiol 53:623–632.

    Article  PubMed  Google Scholar 

  30. Pazhenkottil AP, Nkoulou RN, Ghadri JR et al (2011) Prognostic value of cardiac hybrid imaging integrating single-photon emission computed tomography with coronary computed tomography angiography. Eur Heart J 32:1465–1471.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nuclear Medicine, University Hospital Zurich, Switzerland

    Philipp A. Kaufmann & Tobias A. Fuchs

Authors
  1. Philipp A. Kaufmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tobias A. Fuchs
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University Hospital, Zurich, Switzerland

    J. Hodler (Radiology) & G. K. von Schulthess (Nuclear Medicine) (Radiology) &  (Nuclear Medicine)

  2. Kantonsspital, Baden, Switzerland

    R. A. Kubik-Huch (Radiology) (Radiology)

  3. Kilchberg/Zurich, Switzerland

    Ch. L. Zollikofer

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Italia

About this chapter

Cite this chapter

Kaufmann, P.A., Fuchs, T.A. (2015). Integrated Cardiac Imaging. In: Hodler, J., von Schulthess, G.K., Kubik-Huch, R.A., Zollikofer, C.L. (eds) Diseases of the Chest and Heart 2015–2018. Springer, Milano. https://doi.org/10.1007/978-88-470-5752-4_26

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-5752-4_26

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5751-7

  • Online ISBN: 978-88-470-5752-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation