Abstract
Primary or secondary peritoneal surface involvement represents an important occurrence in the history of patients with gastrointestinal and gynecological tumors, representing a clinical entity grouped under the name of peritoneal surface malignancies (PSM). Patient life expectancy and quality of life (QoL) are very poor when the disease had reached this phase. In the past, oncologists considered peritoneal carcinosis (PC) as a distant metastasis and therefore as an incurable intra-abdominal disease. Definitely, notwithstanding the advances in systemic chemotherapy regimens, the effects on PC are still limited, probably because of the peritoneal-plasma barrier, which prevents effective drug delivery from the systemic circulation into the peritoneal cavity [1–3]. However, novel therapeutic approaches have been attempted for patients with isolated peritoneal metastases of PSM. Indeed, disease is often restricted to the peritoneal cavity without extra-abdominal involvement, and therefore, it is possible to consider PC as a locoregional disease, and a locoregional approach is thus reasonable for treating these malignancies in humans [4].
Keywords
- Gastric Cancer
- Epithelial Ovarian Carcinoma
- Hyperthermic Intraperitoneal Chemotherapy
- Optimal Cytoreduction
- Malignant Peritoneal Mesothelioma
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Costantini, B., Fagotti, A., Montori, G., Coccolini, F., Ansaloni, L., Scambia, G. (2015). New Trials. In: Di Giorgio, A., Pinto, E. (eds) Treatment of Peritoneal Surface Malignancies. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-5711-1_25
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DOI: https://doi.org/10.1007/978-88-470-5711-1_25
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