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Gonadal Tumors

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Abstract

Gonadal tumors are rare in childhood, with the peak of incidence at 8–9 years and at 19 years. A conservative surgical procedure, such as tumorectomy with gonadal preservation, should be attempted in benign tumors, when possible, the laparoscopic approach is the treatment of choice. Also patients diagnosed with malignant tumors have good prognosis after adequate surgical treatment and, possibly, chemotherapy. Improvements in discovery, diagnosis, minimally invasive surgery management and chemotherapy have required changes in clinical practice, which is aimed at reducing morbidity, such as gonadal dysfunction, without compromising cure rates. Surgery continues to play a crucial role in the treatment of gonadal tumors. Future progress can be achieved by improving the understanding of tumor biology, the risk-stratification of patients, the modulation of chemotherapy and the use of laparoscopic techniques.

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References

  1. Mertens AC, Yasui Y, Neglia JP et al (2001) Late mortality experience in five-year survivors of childhood and adolescent cancer: the Childhood Cancer Survivor Study. J Clin Oncol 19:3163–3172

    CAS  PubMed  Google Scholar 

  2. Bosl GJ, Geller NL, Bajorin D et al (1988) A randomized trial of etoposide and cisplatin versus vinblastine + bleomycin + cisplatin + cyclophosphamide + dactinomycin in patients with good prognosis germ cell tumors. J Clin Oncol 6:1231

    CAS  PubMed  Google Scholar 

  3. Williams S, Birch R, Einhorn L (1987) Treatment of disseminated germ cell tumors with cisplatin, bleomycin, and either vinblastine or etoposide. N Engl J Med 316:1435

    Article  CAS  PubMed  Google Scholar 

  4. Landier W, Wallace WH, Hudson MM. Long-term follow-up of pediatric cancer survivors: education, surveillance, and screening. Pediatr Blood Cancer. 2006;46(2):149–58

    Google Scholar 

  5. AIRTUM Workin Group. Italian Cancer Figures – Report 2012 (2012) Childhood cancer: incidence, survival, trends. Epidemiol Prev 37(1):164–169

    Google Scholar 

  6. Ries LA, Gurney JG, Linet M et al (1999) Cancer incidence and survival among children and adolescents: United States SEER Program 1975–1995, National Cancer Institute, SEER Program. NIH Pub, Bethesda

    Google Scholar 

  7. Cronen PW, Nagaraj HS (1988) Ovarian tumors in children. South Med J 81:464

    Article  CAS  PubMed  Google Scholar 

  8. Brosman SA (1979) Testicular tumors in prepubertal children. Urology 13:581

    Article  CAS  PubMed  Google Scholar 

  9. Weissbach L, Altwein JE, Stiens R (1984) Germinal testicular tumors in childhood. Eur Urol 10:73

    CAS  PubMed  Google Scholar 

  10. Malogolowkin MH, Ortega JA, Krailo M et al (1989) Immature teratomas: identification of patients at risk for malignant recurrence. J Natl Cancer Inst 81:870–874

    Article  CAS  PubMed  Google Scholar 

  11. Norris HJ, Zirkin HJ, Benson WL (1976) Immature (malignant) teratoma of the ovary: a clinical and pathological study of 58 cases. Cancer 37:2359–2372

    Article  CAS  PubMed  Google Scholar 

  12. Gobel U, Schneider DT, Calaminus G et al (2000) Germ cell tumors in childhood and adolescence. Ann Oncol 11:263–271

    Article  CAS  PubMed  Google Scholar 

  13. Billmire D, Vinocur C, Rescorla F et al (2001) Malignant mediastinal germ cell tumors: an intergroup study. J Pediatr Surg 36:18–24

    Article  CAS  PubMed  Google Scholar 

  14. Billmire D, Vinocur C, Rescorla F et al (2004) Outcome and staging evaluation in malignant germ cell tumors of the ovary in children and adolescents: an intergroup study. J Pediatr Surg 39:424–429

    Article  CAS  PubMed  Google Scholar 

  15. Ross JH, Rybicki L, Kay R (2002) Clinical behavior and contemporary management algorithm for prepubertal testis tumors: a summary of the prepubertal testis tumor registry. J Urol 168:1675–1679

    Article  PubMed  Google Scholar 

  16. Rutgers JL, Scully RE (1992) Pathology of the testes in intersex syndromes. Semin Diagn Pathol 4:275–291

    Google Scholar 

  17. Manuel M, Katayama PK, Jones HW Jr (1976) The age of occurrence of gonadal tumors in intersex patients with a Y chromosome. Am J Obstet Gynecol 124:293–300

    CAS  PubMed  Google Scholar 

  18. Fonkalsrud EW (1978) The undescended testis. Curr Probl Surg 15:1–56

    Article  CAS  PubMed  Google Scholar 

  19. Campbell HE (1942) Incidence of malignant growth of the undescended testicle. Arch Surg 44:353–369

    Article  Google Scholar 

  20. Johnson DE, Woodhead DM, Pohl DR et al (1968) Cryptorchidism and testicular tumorigenesis. Surgery 63:919–922

    CAS  PubMed  Google Scholar 

  21. Sohval AR (1954) Testicular dysgenesis as an etiologic factor in cryptorchidism. J Urol 72:693–702

    CAS  PubMed  Google Scholar 

  22. Jones BJ, Thornhill JA, O’Donnell B et al (1991) Influence of prior orchiopexy on stage and prognosis of testicular cancer. Eur Urol 19:201–203

    CAS  PubMed  Google Scholar 

  23. Surti U, Hoffner L, Chakravarti A et al (1990) Genetics and biology of human ovarian teratomas: I. Cytogenetic analysis and mechanism of origin. Am J Hum Genet 47:635

    CAS  PubMed Central  PubMed  Google Scholar 

  24. Inoue M, Fujita M, Azuma C et al (1992) Histogenetic analysis of ovarian germ cell tumors by DNA fingerprinting. Cancer Res 52:6823

    CAS  PubMed  Google Scholar 

  25. Ohama K, Nomura K, Okamoto E et al (1985) Origin of immature teratoma of the ovary. Am J Obstet Gynecol 152:896

    Article  CAS  PubMed  Google Scholar 

  26. Silver SA, Wiley JM, Perlman EJ (1994) DNA ploidy analysis of pediatric germ cell tumors. Mod Pathol 7:951

    CAS  PubMed  Google Scholar 

  27. Brennan BM, Rahim A, Mackie EM et al (1998) Growth hormone status in adults treated for acute lymphoblastic leukaemia in childhood. Clin Endocrinol 48:777–783

    Article  CAS  Google Scholar 

  28. Littley MD, Shalet SM, Beardwell CG et al (1999) Hypopituitarism following external radiotherapy for pituitary tumours in adults. Q J Med 70:145–160

    Google Scholar 

  29. Didcock E, Davies HA, Didi M et al (1995) Pubertal growth in young adult survivors of childhood leukaemia. J Clin Oncol 13:2503–2507

    CAS  PubMed  Google Scholar 

  30. Valla JS for the Group d’Etude en Urologie Pediatrique (2001) Testis sparing surgery for benign testicular tumor in children. J Urol 165:2280–2283

    Article  Google Scholar 

  31. Wu JT, Book L, Sudar K (1981) Serum alpha fetoprotein (AFP) levels in normal infants. Pediatr Res 15(1):50–52

    Article  CAS  PubMed  Google Scholar 

  32. Harms D, Janig U (1986) Germ cell tumors of childhood. Virchows Arch 409:223–229

    Article  CAS  Google Scholar 

  33. Belchis DA, Mowry J, Davis JH (1993) Infantile choriocarcinoma. Cancer 72:2028–2032

    Article  CAS  PubMed  Google Scholar 

  34. Lahdenne P, Pitkänen S, Rajantie J et al (1997) International Germ Cell Cancer Collaborative Group: International Germ Cell Classification: a prognostic factor-based staging system for metastatic germ cell cancer. J Clin Oncol 15:594–603

    Google Scholar 

  35. Müller AM, Söndgen D, Strunz R, Müller KM (2002) Gliomatosis peritonei: a report of two cases and review of the literature. Eur J Obstet Gynecol Reprod Biol 100(2):213–222

    Article  PubMed  Google Scholar 

  36. Mulligan RM (1975) Pathogenesis of teratoid tumors of the ovary and testis. Pathol Annu 10:271–298

    CAS  PubMed  Google Scholar 

  37. Kurman RJ, Norris H (1976) Endodermal sinus tumor of the ovary: a clinical and pathologic analysis of 71 cases. Cancer 38:2404–2419

    Article  CAS  PubMed  Google Scholar 

  38. Cangir A, Smith J, van Eys J (1978) Improved prognosis in children with ovarian cancers following modified VAC (vincristine sulfate, dactinomycin, and cyclophosphamide) chemotherapy. Cancer 42:1234–1238

    Article  CAS  PubMed  Google Scholar 

  39. Pinkerton CR, Pritchard J, Spitz L (1986) High complete response rate in children with advanced germ cell tumors using cisplatin- containing combination chemotherapy. J Clin Oncol 4:194–199

    CAS  PubMed  Google Scholar 

  40. Protocollo TCMG AIEOP (2004) https://www.aieop.org/index.php

  41. Rogers PC, Olson TA, Cullen JW, Pediatric Oncology Group 9048; Children's Cancer Group 8891 et al (2004) Treatment of children and adolescents with stage II testicular and stages I and II ovarian malignant germ cell tumors: a Pediatric Intergroup Study – Pediatric Oncology Group 9048 and Children’s Cancer Group 8891. J Clin Oncol 22(17):3563–3569

    Article  PubMed  Google Scholar 

  42. Cushing B, Giller R, Cullen JW et al (2004) Pediatric Oncology Group Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study – Pediatric Oncology Group 9049 and Children’s Cancer Group 8882.9049; Children’s Cancer Group 8882. J Clin Oncol 22(13):2691–2700

    Article  CAS  PubMed  Google Scholar 

  43. Cecchetto G, Ferrari A, Bernini G et al (2010) Sex cord stromal tumors of the ovary in children: a clinicopathological report from the Italian TREP project. Pediatr Blood Cancer 56(7):1062–1067

    Article  PubMed  Google Scholar 

  44. Marina N, Cushing B, Giller R et al (1999) Complete surgical excision is effective treatment for children with immature teratomas with or without malignant elements: a Pediatric Oncology Group/Children’s Cancer Group Intergroup Study. J Clin Oncol 17:2137–2214

    CAS  PubMed  Google Scholar 

  45. Giguere JK, Stablein DM, Spaulding JT, McLeod DG, Paulson DF, Weiss RB (1988) The clinical significance of unconventional orchiectomy approaches in testicular cancer: a report from the Testicular Cancer Intergroup Study. J Urol 139(6):1225–1228

    CAS  PubMed  Google Scholar 

  46. Cecchetto G, Alaggio R, Bisogno G et al (2010) Sex cord-stromal tumors of the testis in children. A clinicopathologic report from the Italian TREP project. J Pediatr Surg 45(9):1868–1873

    Article  PubMed  Google Scholar 

  47. Fallat ME, Hutter J, American Academy of Pediatrics Committee on Bioethics; American Academy of Pediatrics Section on Hematology/Oncology; American Academy of Pediatrics Section on Surgery (2008) Preservation of fertility in pediatric and adolescent patients with cancer. Pediatrics 121(5):e1461–e1469

    Article  PubMed  Google Scholar 

  48. Aubard Y, Piver P, Pech JC, Galinat S, Teissier MP (2001) Ovarian tissue cryopreservation and gynecologic oncology: a review. Eur J Obstet Gynecol Reprod Biol 97(1):5–14

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics – Pediatric Hematology and Oncology “Lalla Seràgnoli”, S. Orsola-Malpighi University Hospital, Via Albertoni 5, Bologna, 40138, Italy

    Riccardo Masetti, Daniele Zama & Francesca Vendemini

  2. Department of Pediatrics, S. Orsola-Malpighi University Hospital, Via Albertoni 5, Bologna, 40138, Italy

    Andrea Pession

Authors
  1. Riccardo Masetti
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  2. Daniele Zama
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  3. Francesca Vendemini
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  4. Andrea Pession
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Correspondence to Andrea Pession .

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Editors and Affiliations

  1. Pediatric Surgery, S. Orsola-Malpighi University Hospital, Bologna, Bologna, Italy

    Mario Lima

  2. Pediatric Urology, Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Milano, Italy

    Gianantonio Manzoni

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Masetti, R., Zama, D., Vendemini, F., Pession, A. (2015). Gonadal Tumors. In: Lima, M., Manzoni, G. (eds) Pediatric Urology. Springer, Milano. https://doi.org/10.1007/978-88-470-5693-0_26

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  • DOI: https://doi.org/10.1007/978-88-470-5693-0_26

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5692-3

  • Online ISBN: 978-88-470-5693-0

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