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Mucinous Neoplasms

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Imaging and Pathology of Pancreatic Neoplasms

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Abstract

Mucinous cystic neoplasms (MCNs) are thick-walled, uni- or multilocular tumors composed of mucin-containing cysts.

These neoplasms occur almost exclusively in women and are mainly located in the body–tail of the pancreas. MCNs encompass a spectrum of lesions from benign lesions (i.e., mucinous cystadenoma—MCA) to invasive mucinous cystadenocarcinoma.

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References

  1. Kosmahl M, Pauser U, Peters K et al (2004) Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal. Virchows Arch 445(2):168–178

    Article  CAS  PubMed  Google Scholar 

  2. Adsay NV (2008) Cystic neoplasia of the pancreas: pathology and biology. J Gastrointest Surg 12(3):401–404

    Article  PubMed  Google Scholar 

  3. Zamboni G, Scarpa A, Bogina G et al (1999) Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol 23(4):410–422

    Article  CAS  PubMed  Google Scholar 

  4. Edge SB, Byrd DR, Compton CC et al (2010) Exocrine and endocrine pancreas. In: AJCC cancer staging manual, vol 24, 7th edn. Springer, New York, pp 285–296

    Google Scholar 

  5. Bosman FT, World Health Organization, International Agency for Research on Cancer (2010) WHO classification of tumours of the digestive system. International Agency for Research on Cancer, Lyon

    Google Scholar 

  6. Hruban RH, Pitman MB, Klimstra DS, American Registry of Pathology, Armed Forces Institute of Pathology (US) (2007) Tumors of the pancreas. Armed Forces Institute of Pathology, Washington, DC

    Google Scholar 

  7. Crippa S, Salvia R, Warshaw AL et al (2008) Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lesson from 163 resected patients. Ann Surg 274(4):571–579

    Article  Google Scholar 

  8. Compagno J, Oertel JE (1978) Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma). A clinicopathologic study of 41 cases. Am J Clin Pathol 69(6):573–580

    CAS  PubMed  Google Scholar 

  9. Fernández-del Castillo C, Targarona J, Thayer SP et al (2003) Incidental pancreatic cysts: clinicopathologic characteristics and comparison with symptomatic patients. Arch Surg 138(4):427–434; discussion 433–434

    Article  PubMed  Google Scholar 

  10. Le Borgne J, de Calan L, Partensky C (1999) Cystadenomas and cystadenocarcinomas of the pancreas: a multiinstitutional retrospective study of 398 cases. French Surgical Association. Ann Surg 230(2):152–161

    Article  PubMed Central  PubMed  Google Scholar 

  11. D’Onofrio M, Gallotti A, Pozzi Mucelli R (2010) Imaging techniques in pancreatic tumors. Expert Rev Med Devices 7(2):257–273

    Google Scholar 

  12. Martinez-Noguera A, D’Onofrio M (2007) Ultrasonography of the pancreas. 1. Conventional imaging. Abdom Imaging 32(2):136–149

    Article  CAS  PubMed  Google Scholar 

  13. Kim YH, Saini S, Sahani D et al (2005) Imaging diagnosis of cystic pancreatic lesions, pseudocyst versus nonpseudocyst. Radiographics 25(3):671–685

    Article  PubMed  Google Scholar 

  14. D’Onofrio M, Zamboni G, Malagò R et al (2005) Pancreatic pathology. In: Quaia E (ed) Contrast media in ultrasonography. Basic principles and clinical applications. Springer, Berlin Heidelberg New York, pp 335–347

    Chapter  Google Scholar 

  15. D’Onofrio M, Caffarri S, Zamboni G et al (2004) Contrast-enhanced ultrasonography in the characterization of pancreatic cystadenoma. J Ultrasound Med 23(8):1125–1129

    PubMed  Google Scholar 

  16. Sahani DV, Miller JC, del Castillo CF et al (2009) Cystic pancreatic lesions: classification and management. J Am Coll Radiol 6(5):376–380

    Article  PubMed  Google Scholar 

  17. Lewin M, Hoeffel C, Azizi L et al (2008) Imaging of incidental cystic lesions of the pancreas. J Radiol 89(2):197–207

    Article  CAS  PubMed  Google Scholar 

  18. D’Onofrio M, Barbi E, Dietrich CF et al (2012) Pancreatic multicenter ultrasound study (PAMUS). Eur J Radiol 81(4):630–638

    Article  PubMed  Google Scholar 

  19. Rickes S, Wermke W (2004) Differentiation of cystic pancreatic neoplasms and pseudocysts by conventional and echoenhanced ultrasound. J Gastroenterol Hepatol 19(7):761–766

    Article  PubMed  Google Scholar 

  20. D’Onofrio M, Megibow AJ, Faccioli N et al (2007) Comparison of contrast-enhanced sonography and MRI in displaying anatomic features of cystic pancreatic masses. AJR Am J Roentgenol 189(6):1435–1442

    Article  PubMed  Google Scholar 

  21. Pilleul F, Rochette A, Partensky C et al (2005) Preoperative evaluation of intraductal papillary mucinous tumors performed by pancreatic magnetic resonance imaging and correlated with surgical and histopathologic findings. J Magn Reson Imaging 21(3):237–244

    Article  PubMed  Google Scholar 

  22. Megibow AJ, Lombardo FP, Guarise A et al (2001) Cystic pancreatic masses: cross-sectional imaging observations and serial follow-up. Abdom Imaging 26(6):640–647

    Article  CAS  PubMed  Google Scholar 

  23. Morana G, Guarise A (2006) Cystic tumors of the pancreas. Cancer Imaging 13(6):60–71

    Article  Google Scholar 

  24. Goh BK, Tan YM, Thng CH et al (2008) How useful are clinical, biochemical, and cross-sectional imaging features in predicting potentially malignant cystic lesions of the pancreas? Results from a single institution experience with 220 surgically treated patients. J Am Coll Surg 206(1):17–27

    Article  PubMed  Google Scholar 

  25. Sahani DV, Kadavigere R, Blake M et al (2006) Intraductal papillary mucinous tumor of the pancreas: multi–detector row CT with 2D curved reformations-correlation with MRCP. Radiology 238(2):560–569

    Article  PubMed  Google Scholar 

  26. Fishman EK, Jeffrey RB Jr (2004) Multidetector CT: principles, techniques and clinical applications. Lippincott Williams & Wilkins, Philadelphia, p 85

    Google Scholar 

  27. Nino-Murcia M, Jeffrey RB Jr, Beaulieu CF et al (2001) Multidetector CT of the pancreas and bile duct system: value of curved planar reformations. AJR Am J Roentgenol 176(3):689–693

    Article  CAS  PubMed  Google Scholar 

  28. Sahani D, Shah ZK (2006) Soft-organ MDCT imaging: pancreas and spleen. In: Saini S, Rubin GD, Kalra MK (eds) MDCT. A practical approach. Springer, Milan

    Chapter  Google Scholar 

  29. Koito K, Namieno T, Nagakawa T et al (1997) Solitary cystic tumor of the pancreas: EUS-pathologic correlation. Gastrointest Endosc 45(3):268–276

    Article  CAS  PubMed  Google Scholar 

  30. Gress F, Gottlieb K, Cummingd O et al (2000) Endoscopic ultrasound characteristics of mucinous cystic neoplasms of the pancreas. Am J Gastroenterol 95(4):961–965

    Article  CAS  PubMed  Google Scholar 

  31. Ahmad NA, Kochman ML, Lewis JD et al (2001) Can EUS alone differentiate between malignant and benign cystic lesions of the pancreas? Am J Gastroenterol 96(12):3295–3300

    Article  CAS  PubMed  Google Scholar 

  32. Ahmad NA, Kochman ML, Bresinger C et al (2003) Interobserver agreement among endosonographers for the diagnosis of neoplastic versus non-neoplastic pancreatic cystic lesions. Gastrointest Endosc 58(1):59–64

    Article  PubMed  Google Scholar 

  33. Frossard JL, Amouyal P, Amouyal G et al (2003) Performance of endosonography-guided fine needle aspiration and biopsy in the diagnosis of pancreatic cystic lesions. Am J Gastroenterol 98(7):1516–1524

    Article  PubMed  Google Scholar 

  34. Brugge WR, Lewandrowski K, Lee-Lewandrowski E et al (2004) Diagnosis of pancreatic cystic neoplasm: a report of the cooperative pancreatic cyst study. Gastroenterology 126(5):1330–1336

    Article  PubMed  Google Scholar 

  35. van der Waaij LA, van Dullemen HM, Porte RJ (2005) Cyst fluid analysis in the differential diagnosis of pancreatic cystic lesions: a pooled analysis. Gastrointest Endosc 62(3):383–389

    Article  PubMed  Google Scholar 

  36. D’Onofrio M, Gallotti A, Salvia R et al (2011) Acoustic radiation force impulse (ARFI) ultrasound imaging of pancreatic cystic lesions. Eur J Radiol 80(2):241–244

    Article  PubMed  Google Scholar 

  37. D’Onofrio M, Gallotti A, Falconi M et al (2010) Acoustic radiation force impulse ultrasound imaging of pancreatic cystic lesions: preliminary results. Pancreas 39(6):939–940

    Article  PubMed  Google Scholar 

  38. D’Onofrio M, Gallotti A, Mucelli RP (2010) Pancreatic mucinous cystadenoma at ultrasound acoustic radiation force impulse (ARFI) imaging. Pancreas 39(5):684–685

    Article  PubMed  Google Scholar 

  39. D’Onofrio M, Gallotti A, Principe F et al (2010) Contrast-enhanced ultrasound of the pancreas. World J Radiol 2(3):97–102

    Article  PubMed Central  PubMed  Google Scholar 

  40. Claudon M, Cosgrove D, Albrecht T et al (2008) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) – update 2008. Ultraschall Med 29(1):28–44

    Article  CAS  PubMed  Google Scholar 

  41. Hammond N, Miller FH, Sica GT et al (2002) Imaging of cystic disease of the pancreas. Radiol Clin North Am 40(6):1243–1262

    Article  PubMed  Google Scholar 

  42. Xu M, Xie XY, Liu GJ et al (2011) The application value of contrast-enhanced ultrasound in the differential diagnosis of pancreatic solid-cystic lesions. Eur J Radiol 81(7):1432–1437

    Article  PubMed  Google Scholar 

  43. Carlson SK, Johnson CD, Brandt KR et al (1998) Pancreatic cystic neoplasms: the role and sensitivity of needle aspiration and biopsy. Abdom Imaging 23(4):387–393

    Article  CAS  PubMed  Google Scholar 

  44. D’Onofrio M, Zamboni G, Faccioli N et al (2007) Ultrasonography of the pancreas. 4. Contrast-enhanced imaging. Abdom Imaging 32(2):171–181

    Article  PubMed  Google Scholar 

  45. Procacci C, Carbognin G, Accordini S et al (2001) CT features of malignant mucinous cystic tumors of the pancreas. Eur Radiol 11(9):1626–1630

    Article  CAS  PubMed  Google Scholar 

  46. Buetow PC, Rao P, Thompson LD (1998) From the Archives of the AFIP. Mucinous cystic neoplasms of the pancreas: radiologic-pathologic correlation. Radiographics 18(2):433–449

    Article  CAS  PubMed  Google Scholar 

  47. D’Onofrio M, Martone E, Malago R et al (2007) Contrast enhanced ultrasonography of the pancreas. JOP 8(1):71–76

    PubMed  Google Scholar 

  48. Sahani DV, Kadavigere R, Saokar A et al (2005) Cystic pancreatic lesions: a simple imaging-based classification system for guiding management. Radiographics 25(6):1471–1484

    Article  PubMed  Google Scholar 

  49. Warshaw AL, Compton CC, Lewandrowski K et al (1990) Cystic tumors of the pancreas: new clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 212(4):432–443

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  50. Sarr MG, Murr M, Smyrk TC et al (2003) Primary cystic neoplasms of the pancreas: neoplastic disorders of emerging importance—current state-of-the-art and unanswered questions. J Gastrointest Surg 7(3):417–428

    Article  PubMed  Google Scholar 

  51. Mathieu D, Guigui B, Valette PJ et al (1989) Pancreatic cystic neoplasms. Radiol Clin North Am 27(1):163–176

    CAS  PubMed  Google Scholar 

  52. Loftus EV, Olivares-Pakzad BA, Batts KP et al (1996) Intraductal papillary-mucinous tumors of the pancreas: clinicopathologic features, outcome and nomenclature. Gastroenterology 110(6):1909–1918

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiology, G.B. Rossi University Hospital, P.le L.A. Scuro 10, Verona, 37134, Italy

    Mirko D’Onofrio, Riccardo De Robertis & Stefano Crosara

  2. Department of Pathology, G.B. Rossi University Hospital, P.le L.A. Scuro 10, Verona, 37134, Italy

    Paola Capelli & Claudio Luchini

  3. Department of Radiology, Casa di Cura Dott. Pederzoli, via Monte Baldo 24, Verona, Peschiera del Garda, 37019, Italy

    Paolo Tinazzi Martini & Emilio Barbi

  4. Department of Radiology, S. Maria di Ca’ Foncello Hospital, Piazza Ospedale 1, Treviso, 31100, Italy

    Giovanni Morana

Authors
  1. Mirko D’Onofrio
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  2. Paola Capelli
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  3. Riccardo De Robertis
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  7. Emilio Barbi
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  8. Giovanni Morana
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Corresponding author

Correspondence to Mirko D’Onofrio .

Editor information

Editors and Affiliations

  1. Department of Radiology, GB Rossi University Hospital, Verona, Italy

    Mirko D'Onofrio

  2. Department of Pathology, GB Rossi University Hospital, Verona, Italy

    Paola Capelli

  3. Department of Surgery, Casa di Cura Dott. Pederzoli, Peschiera del Garda (Verona), Italy

    Paolo Pederzoli

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D’Onofrio, M. et al. (2015). Mucinous Neoplasms. In: D'Onofrio, M., Capelli, P., Pederzoli, P. (eds) Imaging and Pathology of Pancreatic Neoplasms. Springer, Milano. https://doi.org/10.1007/978-88-470-5678-7_5

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  • DOI: https://doi.org/10.1007/978-88-470-5678-7_5

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  • Publisher Name: Springer, Milano

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  • Online ISBN: 978-88-470-5678-7

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