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Vascular Embryology

  • Chapter
Hemangiomas and Vascular Malformations

Abstract

In developed countries vascular diseases are the leading cause of mortality. With an incidence of up to 5 %, maldevelopment of vessels (mainly hemangiomas, but also lymphangiomas and vascular malformations) is the number one developmental failure observed in newborns and even more often in premature infants. In recent decades, our knowledge of the molecular genetic and epigenetic control of the development of blood vessels (angiogenesis, hemangiogenesis) and lymphatics (lymphangiogenesis) has increased considerably, raising the hope to identify new therapeutic targets. Here we review the cellular and molecular mechanisms of embryonic angiogenesis and lymphangiogenesis in the human and in model organisms. The focus lies on the endothelial and mural cells (pericytes, smooth muscle cells, macrophages), growth factors, and receptors that control their development, proliferation, remodeling, maintenance, regression, and differentiation. Our expanding knowledge of the molecular control of endothelial and mural cell development justifies expanded functional and clinical studies in future.

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  1. Institute of Anatomy and Cell Biology, University Medical Center Goettingen, Goettingen, Germany

    Jörg Wilting

  2. Institute of Anatomy and Embryology, University Medical Center Goettingen, Goettingen, Germany

    Jörg Männer

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  1. Jörg Wilting
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  2. Jörg Männer
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Correspondence to Jörg Wilting .

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Editors and Affiliations

  1. Department of Vascular Surgery, Center for Vascular Malformations "Stefan Belov", Clinical Institute Humanitas "Mater Domini", Castellanza (Varese), Italy

    Raul Mattassi

  2. Vascular Malformations, Facharztklinik Hamburg, Hamburg, Germany

    Dirk A. Loose

  3. Department of Vascular Surgery, "G. Salvini" Hospital, Garbagnate Milanese (Milan), Italy

    Massimo Vaghi

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© 2015 Springer-Verlag Italia

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Wilting, J., Männer, J. (2015). Vascular Embryology. In: Mattassi, R., Loose, D., Vaghi, M. (eds) Hemangiomas and Vascular Malformations. Springer, Milano. https://doi.org/10.1007/978-88-470-5673-2_1

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  • DOI: https://doi.org/10.1007/978-88-470-5673-2_1

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5672-5

  • Online ISBN: 978-88-470-5673-2

  • eBook Packages: MedicineMedicine (R0)

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