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Pharmacological Induction of Hypothermia

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Abstract

Mild to moderate hypothermia exerted extraordinary protection against traumatic ischemic-hypoxic brain injury and consequently produced long-term beneficial clinic effects. Currently, the routine methods for inducing hypothermia mainly rely on physical strategies. Those shortcomings of the physical hypothermia limited the widely use of this life-saving intervention and also negated the beneficial effects of hypothermia. Recently, pharmacological method has emerged as a novel option for induction of hypothermia as to its easy implementation. There have been a series of drugs reported to induce hypothermia, such as the cannabinoids, opioid receptor agonists, transient receptor potential vanilloid, neurotensins, thyroxine derivatives, dopamine receptor agonists, cholecystokinin. It would provide broad clinical implications and insights understanding the interactions between neuroprotection and pharmacological hypothermia.

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Authors and Affiliations

  1. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Yanjiang West Road, 510120, Guangzhou, China

    Yinlun Weng

  2. The Institute of Critical Care Medicine, Bob Hope Drive, Rancho Mirage, CA, 92270, USA

    Shijie Sun & Wanchun Tang

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  1. Yinlun Weng
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  2. Shijie Sun
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  3. Wanchun Tang
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Correspondence to Wanchun Tang .

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  1. UCO di Anestesia e Rianimazione, Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele, Catania, Italy

    Antonino Gullo

  2. Dept. Cardiovascular research, Istituto Mario Negri, Milano, Milano, Italy

    Giuseppe Ristagno

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Weng, Y., Sun, S., Tang, W. (2014). Pharmacological Induction of Hypothermia. In: Gullo, A., Ristagno, G. (eds) Resuscitation. Springer, Milano. https://doi.org/10.1007/978-88-470-5507-0_15

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  • DOI: https://doi.org/10.1007/978-88-470-5507-0_15

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