Abstract
Paget’s disease (PD) of the breast was first described by James Paget in 1874 [1]
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Paget J (1874) On the disease of the mammary areola preceding cancer of the mammary gland. St Bartholomews Hosp Rep 10:87–89
Tavassoli FA (1999) Pathology of the breast. Appleton and Lange, Norwalk, Connecticut, pp731–760
Sakorafas GH, Blanchard K, Sarr MG et al (2001) Paget’s disease of the breast. Cancer Treat Rev 27:9–18
Liegl B, Leibl S, Gogg-Kamerer M et al (2007) Mammary and extramammary Paget’s disease: an immunohistochemical study of 83 cases. Histopathology 50:439–447
Smith KJ, Tuur S, Corvette D et al (z) Cytokeratin 7 staining in mammary and extramammary Paget’s disease. Mod Pathol 11:1069–1074
Yao DX, Hoda SA, Chiu A et al (2002) Intraepidermal cytokeratin 7 immunoreactive cells in the non-neoplastic nipple may represent interepithelial extension of lactiferous duct cells. Histopathology 40:230–236
Kanitakis J (1998) Solid cutaneous tumours. In: Kanitakis J, Vassileva S, Woodley D (ed) Diagnostic Immunohistochemistry of the Skin. Chapman and Hall Medical, London, pp 279–299
Schelfhout VR, Coene ED, Delaey B et al (2000) Pathogenesis of Paget’s disease: epidermal heregulin-alpha, motility factor, and the HER receptor family. J Natl Cancer Inst 92:622–628
Yim JH, Wick MR, Philpott GW et al (1997) Underlying pathology in mammary Paget’s disease. Ann Surg Oncol 4:287–292
Chaudary MA, Millis RR, Lane EB et al (1986) Paget’s disease of the nipple: a 10-year review including clinical, pathological and immunohistochemical findings. Breast Cancer Res Treat 8:139–146
Kollmorgen DR, Varanasi JS, Edge SB et al (1998) Paget’s disease of the breast: a 33-year experience. J Am Coll Surg 187:171–177
Muir R (1935) The pathogenesis of Paget’s disease of the nipple and associated lesions. Br J Surg 22:728–737
Muir R (1939) Further observation on Paget’s disease of the nipple. J Pathol Bacteriol 49:299
Sagami S (1963) Electron microscopic studies in Paget’s disease. Med J Osaka Univ 14:173–188
Jahn H, Osther PJ, Nielsen EH et al (1995) An electron microscopic study of clinical Paget’s disease of the nipple. APMIS 103:628–634
Marucci G, Betts CM, Golouh R et al (2002) Toker cells are probably precursors of Paget cell carcinoma: a morphological and ultrastructural description. Virchows Arch 441:117–123
Morandi L, Pession A, Marucci GL et al (2003) Intraepidermal cells of Paget’s carcinoma of the breast can be genetically different from those of the underlying carcinoma. Hum Pathol 34:1321–1330
Frei KA, Bonel HM, Pelte MF et al (2005) Paget disease of the breast: findings at magnetic resonance imaging and histopathologic correlation. Invest Radiol 40:363–367
Morrogh M, Morris EA, Liberman L et al (2008) MRI identifies otherwise occult disease in select patients with Paget disease of the nipple. J Am Coll Surg 206:316–321
Paone JF, Baker RR (1981) Pathogenesis and treatment of Paget’s disease of the breast. Cancer 48:825–829
Bijker N, Rutgers EJ, Duchateau L et al (2001) Breast-conserving therapy for Paget disease of the nipple: a prospective European Organization for Research and Treatment of Cancer study of 61 patients. Cancer 91:472–477
Kawase K, DiMaio DJ, Tucker SL et al (2005) Paget’s Disease of the Breast: There Is a Role for Breast-Conserving Therapy. Ann Surg Oncol 12:1–7
Marshall JK, Griffith KA, Haffty BG et al (2003) Conservative management of Paget disease of the breast with radiotherapy: 10-and 15-year results. Cancer 97:2142–2149
Pierce LJ, Haffty BG, Solin LJ et al (1997) The conservative management of Paget’s disease of the breast with radiotherapy. Cancer 80:1065–1072
Singh A, Sutton RJ, Baker CB et al (1999) Is mastectomy overtreatment for Paget’s disease of the nipple? Breast 8(4):191–194
Veronesi U, Cascinelli N, Mariani L et al (2002) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347:1227–1232
Fisher B, Anderson S, Bryant J et al (2002) Twenty-year follow up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347:1233–1241
Bulens P, Vanuytsel L, Rijnders A et al (1990) Breast conserving treatment of Paget’s disease. Radiother Oncol 17:305–309
Stockdale AD, Brierley JD, White WF et al (1989) Radiotherapy for Paget’s disease of the nipple: a conservative alternative. Lancet 2:664–666
Fourquet A, Campana F, Vielh P et al (1987) Paget’s disease of the nipple without detectable breast tumor: conservative management with radiation therapy. Int J Radiat Oncol Biol Phys 13:1463–1465
Laronga C, Hasson D, Hoover S et al (2006) Paget’s disease in the era of sentinel lymph node biopsy. Am J Surg 192:481–483
Sukumvanich P, Bentrem DJ, Cody HS et al (2007) The role of sentinel lymph node biopsy in Paget’s Disease of the breast. Ann Surg Oncol 14:1020–1023
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Italia
About this chapter
Cite this chapter
Sanchez, L.J., Bernini, M., Cucchiari, J.N. (2014). Paget’s Disease. In: Mariotti, C. (eds) Oncologic Breast Surgery. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-5438-7_9
Download citation
DOI: https://doi.org/10.1007/978-88-470-5438-7_9
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-5437-0
Online ISBN: 978-88-470-5438-7
eBook Packages: MedicineMedicine (R0)