Abstract
Patient candidates to lung transplant could die awaiting organ allocation due to the worsening of their end-stage respiratory failure. In recent years, the outcome improvement after lung transplant, a more accurate patient selection and the technological development of simpler and safer extracorporeal systems, has made the use of extracorporeal membrane oxygenation (ECMO) as bridge to lung transplant possible in the critically ill patients. The correct choice of the extracorporeal configuration in function to the pathophysiologic characteristics of the end-stage respiratory failure permits performing lung transplants, even in more severe patients, decreasing perioperative morbidity and mortality.
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References
Christie JD, Edwards LB, Kucheryavaya AY et al (2012) The registry of the International Society for Heart and Lung Transplantation: 29th adult lung and heart-lung transplant report-2012. J Heart Lung Transplant 10:1073–1086
Vermeijden JW, Zijlstra JG, Erasmus ME et al (2009) Lung transplantation for ventilator-dependent respiratory failure. J Heart Lung Transplant 28:247–351
Stern JB, Mal H, Groussard O et al (2001) Prognosis of patients with advanced idiopathic pulmonary fibrosis requiring mechanical ventilation for acute respiratory failure. Chest 120:213–219
Del Sorbo L, Boffini M, Rinaldi M et al (2012) Bridging to lung transplantation by extracorporeal support. Minerva Anestesiol 78:243–250
Veith F (1977) Lung transplantation. Transplant Proc 9:203–208
Chandra A, Jena AB, Skinner JS (2011) The pragmatist’s guide to comparative effectiveness research. J Econ Perspect 25:27–46
Egan TM, Kotloff RM (2005) Pro/Con debate: lung allocation should be based on medical urgency and transplant survival and not on waiting time. Chest 128:407–415
Fischer S, Simon AR, Welte T et al (2006) Bridge to lung transplantation with the novel pumpless interventional lung assist device NovaLung. J Thorac Cardiovasc Surg 131:719–723
Cypel M, Waddel TH, de Perrot M et al (2010) Safety and efficacy of the NovaLung Interventional Lung Assist (iLA) device as a bridge to lung transplantation. J Heart Lung Transplant 29:S88
Ricci D, Boffini M, Del Sorbo L et al (2010) The use of CO2 removal devices in patients awaiting lung transplantation: an initial experience. Transplant Proc 42:1255–1258
Hammainen P, Schersten H, Lemstrom K et al (2011) Usefulness of extracorporeal membrane oxygenation as a bridge to lung transplantation: a descriptive study. J Heart Lung Transplant 30:103–107
Bermudez CA, Rocha RV, Zaldonis D et al (2011) Extracorporeal membrane oxygenation as a bridge to lung transplant: midterm outcomes. Ann Thorac Surg 92:1226–1231
Fuehner T, Kuehn C, Hadem J et al (2012) Extracorporeal membrane oxygenation in awake patients as bridge to lung transplantation. Am J Respir Crit Care Med 185:763–768
Lang G, Taghavi S, Aigner C et al (2012) Primary lung transplantation after bridge with extracorporeal membrane oxygenation: a plea for a shift in our paradigms for indications. Transplantation 93:729–736
Javidar J, Brodie D, Iribarne A et al (2012) Extracorporeal membrane oxygenation as a bridge to lung transplantation and recovery. J Thorac Cardiovasc Surg 144:716–721
Shafii AE, Mason DP, Brown CR et al (2012) Growing experience with extracorporeal membrane oxygenation as a bridge to lung transplantation. ASAIO J 58:526–529
Toyoda Y, Bhama JK, Shigemura N et al (2013) Efficacy of extracorporeal membrane oxygenation as a bridge to lung transplantation. J Thorac Cardiovasc Surg 145:1065–1071
Hoopes CW, Kukreja J, Golden J et al (2013) Extracorporeal membrane oxygenation as a bridge to pulmonary transplantation. J Thorac Cardiovasc Surg 145:862–868
Crotti S, Iotti GA, Lissoni A et al (2013) The organ allocation waiting time during extracorporeal bridge to lung transplantation affects outcomes. Chest 144(3):1018–1025
Orens JB, Estenne M, Arcasoy S et al (2006) International guidelines for the selection of lung transplant candidates: 2006 update—a consensus report from the pulmonary scientific council of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 25:745–755
Wickerson L, Mathur S, Brooks D (2010) Exercise training after lung transplantation: a systematic review. J Heart Lung Transplant 29:497–503
Jackson A, Cropper J, Pye R et al (2008) Use of extracorporeal membrane oxygenation as a bridge to primary lung transplant: 3 consecutive, successful cases and a review of the literature. J Heart Lung Transplant 27:348–352
Benzing A, Mols G, Brieschal T et al (1997) Hypoxic pulmonary vasoconstriction in nonventilated lung areas contributes to difference in hemodynamic and gas exchange responses to inhalation of nitric oxide. Anesthesiology 86:1254–1261
Stohr F, Emmert MY, Lachat ML et al (2011) Extracorporeal membrane oxygenation for acute respiratory distress syndrome: is the configuration mode an important predictor for the outcome? Interact Cardiovasc Thorac Surg 12:676–680
Camboni D, Akay B, Sassalos P et al (2011) Use of venovenous extracorporeal membrane oxygenation and an atrial septostomy for pulmonary and right ventricular failure. Ann Thorac Surg 91:144–149
Strueber M, Hoeper MM, Fischer S et al (2009) Bridge to thoracic organ transplantation in patients with pulmonary arterial hypertension using a pumpless lung assist device. Am J Transplant 9:853–857
Rich PB, Awad SS, Crotti S et al (1998) A prospective comparison of atrio-femoral and femoro-atrial flow in adult venovenous extracorporeal life support. J Thorac Cardiovasc Surg 116:628–632
Diaz-Guzman E, Hoopes CW, Zwischenberger JB (2013) The evolution of extracorporeal life support as a bridge to lung transplantation. ASAIO J 59:3–10
Olsson KM, Simon A, Strueber M et al (2010) Extracorporeal membrane oxygenation in nonintubated patients as bridge to lung transplantation. Am J Transplant 10:1–6
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Crotti, S., Lissoni, A. (2014). ECMO as a Bridge to Lung Transplant. In: Sangalli, F., Patroniti, N., Pesenti, A. (eds) ECMO-Extracorporeal Life Support in Adults. Springer, Milano. https://doi.org/10.1007/978-88-470-5427-1_25
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DOI: https://doi.org/10.1007/978-88-470-5427-1_25
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