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Anesthesia of the Upper Limb pp 253–259Cite as

Perineural Adjuvants for Postoperative Analgesia

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Abstract

The story began in the late 1990s with a visit I paid to the Pain Therapy Center of the University of Wűrzburg in Germany, directed by Professor Sprotte, who is familiar to everyone on account of the spinal needle he devised. He was treating cases of cervicobrachialgia, performing a stellate ganglion block with one-tenth of an ampoule of buprenorphine, further diluted with 7 ml of saline. The results were astonishing.

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Bibliography

  • Alemanno F, Danelli G, Fanelli A, Ghisi D, Bizzarri F, Fanelli G (2012) Tramadol and 0.5 levobupivacaine for brachial interscalene block: effects on postoperative analgesia in patients undergoing shoulder arthroplasty. Minerva Anestesiol 78(3):291–296

    PubMed  CAS  Google Scholar 

  • Antonucci S (2001) Adiuvanti nel blocco del plesso brachiale per via ascellare: confronto tra clonidina, sufentanil e tramadolo. Minerva Anestesiol 67:23–27

    PubMed  CAS  Google Scholar 

  • Arcioni R et al (2002) Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT3 spinal receptor involvement in acute pain in humans. Anesth Analg 94:1553–1557

    PubMed  CAS  Google Scholar 

  • Arend I, von Arnim B, Nijssen J, Scheele J, Flohé L (1978) Tramadol und Pentazocin im Klinischen-Doppelblind-Crossover Vergleich. Arzneim Forsch 28:199–208

    CAS  Google Scholar 

  • Baba H, Kohno T, Okamoto M, Goldstein PA, Shimoji K, Yoshimura M (1998) Muscarinic facilitation of GABA release in substantia gelatinosa of the rat spinal dorsal horn. J Physiol 508:83–93

    Article  PubMed  CAS  Google Scholar 

  • Behr A, Freo U, Ori C, Westermann B, Alemanno F (2012) Buprenorphine added to levobupivacaine enhances postoperative analgesia of middle interscalene brachial plexus block. J Anesth, 26(5):746–751

    Google Scholar 

  • Candido KD, Franco CD, Kahn MA, Winnie AP, Raja DS (2001) Buprenorphine added to the local anesthetic for brachial plexus block to provide postoperative analgesia in outpatients. Reg Anesth Pain Med 26:352–356

    PubMed  CAS  Google Scholar 

  • Candido KD, Hennes J, Gonzalez S, Mikat-Stevens M, Pinzur M, Vasic V, Knezevic NN (2010) Buprenorphine enhances and prolongs the postoperative analgesic effect of bupivacaine in patients receiving infragluteal sciatic nerve block. Anesthesiology 113:1419–1426

    Article  PubMed  CAS  Google Scholar 

  • Candido KD, Winnie AP, Ghaleb AH, Fattouh MW, Franco CD (2002) Buprenorphine added to the local anesthetic for axillary brachial plexus block prolongs postoperative analgesia. Reg Anesth Pain Med 27:162–167

    PubMed  CAS  Google Scholar 

  • Culebras X, Van Gessel E, Hoffmeyer P, Gamulin Z (2001) Clonidine combined with a long acting local anesthetic does not prolong postoperative analgesia after brachial plexus block but does induce hemodynamic changes. Anesth Analg 92:199–204

    Article  PubMed  CAS  Google Scholar 

  • Dayer P, Desmeules J, Collart L (1997) Pharmacologie du tramadol. Drugs 53(Suppl. 2):18–24

    Article  PubMed  CAS  Google Scholar 

  • Desmeules JA, Piguet V, Collart L, Dayer P (1996) Contribution of monoaminergic modulation to the analgesic effect of Tramadol. Br J Clin Pharmacol 41:7–12

    Article  PubMed  CAS  Google Scholar 

  • Driessen B, Reimann W (1992) Interaction of the central analgesic tramadol, with the uptake and release of 5-hydroxytryptamine in the rat brain in vitro. Br J Pharmacol 105:147–151

    Google Scholar 

  • Fields HL, Emson PC, Leigh BK, Gilbert RF, Iversen LL (1980) Multiple opiate receptor sites on primary afferent fibers. Nature 284:351–353

    Article  PubMed  CAS  Google Scholar 

  • Fleetwood-Walker SM, Mitchell R, Hope PJ, Molony V, Iggo A (1985) An alpha 2 receptor mediates the selective inhibition by noradrenaline of nociceptive responses of identified dorsal horn neurones. Brain Res 334:243–254

    Article  PubMed  CAS  Google Scholar 

  • Flohe L, Arend I et al (1978) Klinische Prüfung der Abhängigkeitsentwicklung nach Langzeitapplikation von Tramadol. Arzneim Forschung 28:213–217

    CAS  Google Scholar 

  • Ian Carrol et al (2007) The role of adrenergic receptors and pain: the good, the bad, and the unknown. Semin Anesth Perioper Med Pain, 26:17–21

    Google Scholar 

  • Kaiser V, Besson JM, Guilbaud G (1991) Effects of analgesic agent Tramadol in normal and arthritic rats: comparison with effects of different opioids, including tolerance and cross-tolerance to morphine. Eur J Pharmacol 195:37–45

    Article  Google Scholar 

  • Kapral S, Gollmann G, Waltl B et al (1999) Tramadol added to mepivacaine prolongs the duration of an axillary brachial plexus blockade. Anesth Analg 88:853–856

    PubMed  CAS  Google Scholar 

  • Kuraishi Y, Hirota N, Sato Y, Kaneko S, Satoh M, Takagi H (1985) Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn. Brain Res 359:177–182

    Article  PubMed  CAS  Google Scholar 

  • Lutfy K, Cowan A (2004) Buprenorphine: a unique drug with complex pharmacology. Curr Neuropharmacol 2(4):395–402

    Article  PubMed  CAS  Google Scholar 

  • McCartney CJL (2007) Analgesic adjuvants in the peripheral nervous system. In: Hadzic A (ed) Textbook of regional anesthesia. Mc Graw Hill, New York, p 149

    Google Scholar 

  • Pertovaara A (2006) Noradrenergic pain modulation. Progr Neurobiol 80:53–83

    Article  CAS  Google Scholar 

  • Pleuvry B (2005) Opioid mechanisms and opioid drugs. Anaesth Intens Care Med 6:1

    Article  Google Scholar 

  • Putzu M, Casati A (2007) Local anesthetic solutions for continuous nerve blocks. In: Hadzic A (ed) Textbook of regional anesthesia. Mc Graw Hill, New York, p 163

    Google Scholar 

  • Raffa RB, Friderichs E, Reimann W et al (1993) Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol. J Pharmacol Exp Ther 267(1):331–340

    PubMed  CAS  Google Scholar 

  • Reimann W et al (1990) Does a non-opioid component contribute to the efficacy of the central analgesic tramadol? 10th european winter conference on brain research, March 3–10

    Google Scholar 

  • Robaux S, Blunt C, Viel E, Cuvillon P et al (2004) Tramadol added to 1.5 % mepivacaine for axillary brachial plexus block improves postoperative analgesia dose-dependently. Anesth Analg 98:1172–1177

    Article  PubMed  CAS  Google Scholar 

  • Sawinor J (2003) Topical and peripherally acting analgesics. Pharmacol Rev, 55:1–20. http://en.wikipedia.org/wiki/clonidine

    Google Scholar 

  • Scott LJ, Perry CM (2000) Tramadol: a review of its use in perioperative pain. Drugs, 60(1):139–176

    Google Scholar 

  • Singelyn FJ, Dangoisse M, Bartholomée S, Gouverneur JM (1992) Adding clonidine to mepivacaine prolongs the duration of anesthesia and analgesia after axillary brachial plexus block. Reg Anesth 17:148–150

    PubMed  CAS  Google Scholar 

  • Stein C (1993) Peripheral mechanism of opioid analgesia. Anesth Analg 76:182–191

    Article  PubMed  CAS  Google Scholar 

  • Stein C (1995) The control of pain in peripheral tissues by opioids. New Engl J Med 332(25):1685–1690

    Article  PubMed  CAS  Google Scholar 

  • Stoffregen J (1980) Kombinationnarkose mit Tramadol-Infusion. Anaesthesiol Intensivmed 29:673–674

    CAS  Google Scholar 

  • Viel EJ, Eledjam JJ, de la Coussaye J, D’Athis F (1989) Brachial plexus block with opioids for postoperative pain relief: comparison between buprenorphine and morphine. Reg Anesth 14:274–278

    PubMed  CAS  Google Scholar 

  • Young WS 3rd, Wamsley JK, Zarbin MA, Kuhar MJ (1980) Opioid receptors undergo axonal flow. Science 210:76–78

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Anesthesiology, Resuscitation and Pain Therapy, University of Verona, Verona, Italy

    F. Alemanno

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  1. F. Alemanno
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Correspondence to F. Alemanno .

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Editors and Affiliations

  1. Institute of Anesthesiology, Resuscitation and Pain Therapy, University of Verona, Verona, Italy

    Fernando Alemanno

  2. Catholic University of the Sacred Heart, Rome, Italy

    Mario Bosco

  3. Pain Therapy Service, Padre Pio Hospital, Mondragone (CE), Italy

    Aldo Barbati

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Alemanno, F. (2014). Perineural Adjuvants for Postoperative Analgesia. In: Alemanno, F., Bosco, M., Barbati, A. (eds) Anesthesia of the Upper Limb. Springer, Milano. https://doi.org/10.1007/978-88-470-5418-9_14

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  • DOI: https://doi.org/10.1007/978-88-470-5418-9_14

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5417-2

  • Online ISBN: 978-88-470-5418-9

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