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PET/CT with [18F]FDG in Endometrial Cancer

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Imaging in Clinical Oncology

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Abstract

Positron emission tomography/computed tomography (PET/CT) with the use of glucose analogue 2-[18F]fluoro-2-deoxy-d-glucose, [18F]FDG, has a major impact in oncology. Nowadays, there is a growing body of evidence supporting the use of [18F]FDG-PET/CT in gynaecological malignancies. Concerning the cervical cancer, imaging with [18F]FDG-PET/CT is not routinely used for the initial diagnosis but the preoperative [18F]FDG uptake in the primary tumour seems to offer significant prognostic information. Also, [18F]FDG-PET/CT is an important tool for initial staging particularly in identifying involved lymph nodes and distant metastasis, while it may impact external-beam radiotherapy planning. Finally, it is reported as an important diagnostic tool for detecting recurrent cervical cancer in clinically equivocal patients and for monitoring post-treatment metabolic response. Concerning the ovarian cancer, [18F]FDG-PET/CT is not used for initial diagnosis because of false positive results but it may contribute to the detection of metastases outside the pelvis in the initial staging. There are published data for the value of [18F]FDG-PET/CT in radiotherapy planning and accurate restaging after treatment, but this method seems to have the greatest utility in ovarian cancer recurrence detection, mainly in patients with an increase of the tumour marker CA-125 and negative or inconclusive findings at CT or MRI. Finally, for the endometrial cancer there are few studies that support that [18F]FDG-PET/CT may play role as a prognostic factor and offer a high accuracy in the evaluation of recurrence.

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Authors and Affiliations

  1. Nuclear Medicine Department, Evangelismos General Hospital, Ipsilantou 45–47, 10676, Athens, Greece

    Evangelia V. Skoura & Ioannis E. Datseris

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  1. Evangelia V. Skoura
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  2. Ioannis E. Datseris
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Correspondence to Ioannis E. Datseris .

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Editors and Affiliations

  1. University of Athens, Greece, Athens, Greece

    Athanasios D. Gouliamos

  2. Hygeia and Mitera Hospital, Athens, Greece

    John Andreou

  3. Hygeia Hospital, Athens, Greece

    Paris Kosmidis

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Skoura, E.V., Datseris, I.E. (2014). PET/CT with [18F]FDG in Endometrial Cancer. In: Gouliamos, A., Andreou, J., Kosmidis, P. (eds) Imaging in Clinical Oncology. Springer, Milano. https://doi.org/10.1007/978-88-470-5385-4_42

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  • DOI: https://doi.org/10.1007/978-88-470-5385-4_42

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5384-7

  • Online ISBN: 978-88-470-5385-4

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