Abstract
Lymphoma is a heterogeneous group of more than 30 distinct types, differing widely in epidemiology and clinical behavior. Once the pathologic diagnosis of lymphoma is established, accurate clinical staging is mandatory for prognostication and appropriate treatment planning. In practically all cases, imaging—anatomic cross sectional imaging (CT and/or MRI) and/or functional imaging (PET or PET/CT)—plays a central role in staging. Furthermore, imaging is used to restage during therapy or at the end of treatment and document or exclude a complete remission. The following chapter examines the role of CT and MRI in lymphoma staging and restaging. Advantages and drawbacks of CT in assessing nodal and extranodal disease at initial presentation are discussed, and its diagnostic value compared with PET/CT is presented. The use of CT in restaging, including its role in the revised 2007 International Harmonization Project response criteria is also addressed. The role of MRI in staging and restaging Primary CNS Lymphoma and the use of Whole-body MRI as an alternative radiation-free imaging modality for lymphoma assessment are discussed in the final section of the chapter.
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References
Matasar MJ, Zelenetz AD (2008) Overview of lymphoma diagnosis and management. Radiol Clin North Am 46(2):175–198
Kwee TC, Kwee RM, Nievelstein RA (2008) Imaging in staging of malignant lymphoma: a systematic review. Blood 111(2):504–516
Cronin CG, Swords R, Truong MT et al (2010) Clinical utility of PET/CT in lymphoma. AJR 194(1):W91–W103
Lister TA, Crowther D, Sutcliffe SB et al (1989) Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds meeting. J Clin Oncol 7(11):1630–1636
American Joint Committee on Cancer (2010) Lymphoid neoplasms. In: AJCC Cancer Staging Manual (7th edn) Springer, New York Dordrecht Heidelberg London, pp 599–615
Aiken AH, Glastonbury C (2008) Imaging Hodgkin and non-Hodgkin lymphoma in the head and neck. Radiol Clin North Am 46(2):363–378
Bae YA, Lee KS (2008) Cross-sectional evaluation of thoracic lymphoma. Radiol Clin North Am 46(2):253–264
Schwartz LH, Bogaerts J, Ford R et al (2009) Evaluation of lymph nodes with RECIST 1.1. Eur J Cancer 45(2):261–267
Hricak H, Husband J, Panicek DM (2009) Essentials of reporting common cancers In: Oncologic Imaging. Saunders Elsevier, Philadelphia, p 12
de Jong PA, van Ufford HM, Baarslag HJ et al (2009) CT and 18F-FDG PET for noninvasive detection of splenic involvement in patients with malignant lymphoma. AJR 192(3):745–753
Cheson BD (2011) Role of functional imaging in the management of lymphoma. J Clin Oncol 29(14):1844–1854
Seam P, Juweid ME, Cheson BD (2007) The role of FDG-PET scans in patients with lymphoma. Blood 110(10):3507–3516
Cheson BD (2009) The case against heavy PETing. J Clin Oncol 27(11):1742–1743
Cheson BD, Horning SJ, Coiffier B et al (1999) Report of an international workshop to standardize response criteria for non-Hodgkin’s lymphomas. J Clin Oncol 17(4):1244–1253
Juweid ME, Stroobants S, Hoekstra OS et al (2007) Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol 25(5):571–578
Cheson BD, Pfistner B, Juweid ME et al (2007) Revised response criteria for malignant lymphoma. J Clin Oncol 25(5):579–586
Vermoolen MA, Kersten MJ, Fijnheer R et al (2011) Magnetic resonance imaging of malignant lymphoma. Expert Rev Hematol 4(2):161–171
Punwani S, Taylor SA, Bainbridge A et al (2010) Pediatric and adolescent lymphoma: comparison of whole-body STIR half-Fourier RARE MR imaging with an enhanced PET/CT reference for initial staging. Radiology 255(1):182–190
Brennan DD, Gleeson T, Coate LE et al (2005) A comparison of whole-body MRI and CT for the staging of lymphoma. AJR 185(3):711–716
Gu J, Chan T, Zhang J et al (2011) Whole-body diffusion-weighted imaging: the added value to whole-body MRI at initial diagnosis of lymphoma. AJR 197(3):W384–W391
Abrey LE, Batchelor TT, Ferreri AJ et al (2005) Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma. J Clin Oncol 23(22):5034–5043
Slone HW, Blake JJ, Shah R et al (2005) CT and MRI findings of intracranial lymphoma. AJR 184(5):1679–1685
Guo AC, Cummings TJ, Dash RC et al (2002) Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology 224(1):177–183
Mohile NA, Deangelis LM, Abrey LE (2008) The utility of body FDG PET in staging primary central nervous system lymphoma. Neuro Oncol 10(2):223–228
Pels H, Juergens A, Schirgens I et al (2010) Early complete response during chemotherapy predicts favorable outcome in patients with primary CNS lymphoma. Neuro Oncol 12(7):720–724
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Koutoulidis, V.C. (2014). Lymphomas: The Role of CT and MRI in Staging and Restaging. In: Gouliamos, A., Andreou, J., Kosmidis, P. (eds) Imaging in Clinical Oncology. Springer, Milano. https://doi.org/10.1007/978-88-470-5385-4_34
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DOI: https://doi.org/10.1007/978-88-470-5385-4_34
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