Abstract
Hemolytic uremic syndrome (HUS) is a multisystemic disease. Besides the kidneys, the central nervous system is clinically involved in 20–50 % of the patients. Common signs of severe CNS injury are seizures, alterations of consciousness, hemiparesis, visual disturbances, and brainstem symptoms. The acute mortality rate is 4–10 %. Morphological brain imaging (CT and MRI) and MRI parametric imaging show structural changes in the basal ganglia, cerebellum, thalami, and brainstem in 20–60 % of HUS patients with clinically severe CNS involvement. The typical 18F-FDG pattern is a significant and diffuse/symmetric impairment of metabolism in the posterior cortex and cerebellum, with minor impairment in the basal ganglia and recovery after clinical healing. A focal/asymmetric pattern of cortical hypoperfusion/hypometabolism in HUS is associated with relevant neurological symptoms/signs in the acute phase.
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Herrera P, Valenzuela C, Skarmeta M, Méndez M, Bustos-González A (2012) Enterocolitis, antimicrobials and hemolytic-uremic syndrome in children: Review of a concept. Rev Chilena Infectol 29(3):313–316
Rota S, Cravedi P, Remuzzi G, Ruggenenti P (2005) Hemolytic uremic syndrome. G Ital Nefrol 22(Suppl 33):S57–S64
Landoni VI, Schierloh P, de Campos Nebel M, Fernández GC, Calatayud C, Lapponi MJ, Isturiz MA (2012) Shiga toxin 1 induces on lipopolysaccharide-treated astrocytes the release of tumor necrosis factor-alpha that alter brain-like endothelium integrity. PLoS Pathog 8(3):e1002632. Epub 2012 Mar 29
Steinborn M, Leiz S, Rüdisser K, Griebel M, Harder T, Hahn H (2004) CT and MRI in haemolytic uraemic syndrome with central nervous system involvement: distribution of lesions and prognostic value of imaging findings. Pediatr Radiol 34(10):805–810
Gómez-Lado C, Martinón-Torres F, Alvarez-Moreno A et al (2007) Reversible posterior leukoencephalopathy syndrome: an infrequent complication in the course of haemolytic-uremic syndrome. Rev Neurol 44(8):475–478
Toldo I, Manara R, Cogo P, Sartori S, Murer L, Battistella PA, Laverda AM (2009) Diffusion-weighted imagng findings in hemolytic uremic syndrome with central nervous system involvement. J Child Neurol 24(2):247–250
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© 2014 Springer-Verlag Italia
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Benti, R., Cistaro, A. (2014). Brain 18F-FDG–PET/CT Imaging in Hemolytic Uremic Syndrome During and After the Acute Phase. In: Cistaro, A. (eds) Atlas of PET/CT in Pediatric Patients. Springer, Milano. https://doi.org/10.1007/978-88-470-5358-8_23
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DOI: https://doi.org/10.1007/978-88-470-5358-8_23
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