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Ranibizumab

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Adverse Events with Biomedicines

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Abstract

Ranibizumab (Lucentis®, Genentech, Novartis) is a recombinant humanized IgG1k monoclonal Fab fragment binding to human vascular endothelial growth factor-A (VEGF-A). In June 2006, FDA approved ranibizumab for intravitreal (IVI) treatment of neovascular age-related (wet) macular degeneration (AMD). In March 2007, EMEA granted approval for the same indication. In June 2010, on the basis of additional data, FDA extended the indication to macular edema following retinal vein occlusion (RVO), and in October 2012 to the treatment of patients with diabetic macular edema (DME).

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Authors and Affiliations

  1. University of Verona, Verona, Italy

    Giuseppe Tridente

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  1. Giuseppe Tridente
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Correspondence to Giuseppe Tridente .

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© 2014 Springer-Verlag Italia

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Tridente, G. (2014). Ranibizumab. In: Adverse Events with Biomedicines. Springer, Milano. https://doi.org/10.1007/978-88-470-5313-7_34

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