Abstract
The diagnosis of leukopenia can be particularly challenging in the critically ill patient, since a reduced number of white blood cells can be associated with many different systemic or hematological disorders. The main causes of leukopenia are reviewed and discussed.
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References
Munshi HG, Montgomery RB (2000) Severe neutropenia: a diagnostic approach. West J Med 172(4):248–252
Newburger PE, Dale DC (2013) Evaluation and Management of patients with isolated neutropenia. Semin Hematol 50(3):198–206
Darmon M, Azoulay E, Alberti C (2002) Impact of neutropenia duration of short term mortality in neutropenic critical ill cancer patients. Intensive Care Med 28(12):1775–1780
Dellinger RP, Levy MM, Rhodes A et al (2013) Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012. Crit Care Med 41(2):580–637
Youinou P, Jamin C, Le Pottier L (2014) Diagnostic criteria for autoimmune neutropenia. Autoimmun Rev 13(4–5):547–576
Andrès E (2008) Idiosyncratic drug-induced agranulocytosis or acute neutropenia. Curr Opin Hematol 15(1):15–21
Andrès E, Krutz JE (2002) Nonchemotherapy drug-induced agranulocytosis : experience of the Strasbourg teaching hospital (1985–2000) and review of the literature. Clin Lab Hematolog 24(2):99–106
Cohen D, Monden M (2013) White blood cell monitoring during long term clozapine treatment. Am J Psychiatry 170(4):366–369
Sokolic R (2013) Neutropenia in primary immunodeficiency. Curr Opin Hematol 20(1):55–65
Douek DC, Picker LJ, Koup RA (2003) T cell dynamics in HIV infection. Annu Rev Immunol 21:265–304
Okoye AA, Picker LJ (2013) CD 4(+) T cell depletion in HIV infection: mechanism of immunological failure. Immunol Rev 254(1):56–64
Legrand M et al (2012) Survival in neutropenic patients with severe sepsis or septic shock. Crit Care Med 40(1):43–49
Dawn B (2014) Investigating an incidental finding of lymphopenia. BMJ 348:172
Portman MD (2014) Routinely test for HIV in everyone presenting with unexplained lymphopenia. BMJ 348:g2433
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Berlot, G., Presello, B., Agbedyro, A. (2015). Leukopenia in the Critically Ill Patient. In: Berlot, G., Pozzato, G. (eds) Hematologic Problems in the Critically Ill. Springer, Milano. https://doi.org/10.1007/978-88-470-5301-4_4
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DOI: https://doi.org/10.1007/978-88-470-5301-4_4
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