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Atlas of Ileoscopy pp 111–114Cite as

Videocapsule Endoscopy and Therapeutic Enteroscopy for the Management of Small Bowel Polyps in a Patient with Peutz-Jeghers Syndrome

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Background

Peutz-Jeghers syndrome (PJS) is characterized by multiple hamartomatous polyps of the gastrointestinal tract and mucocutaneous pigmentation occurring around the body orifices [1–2]. This autosomal dominant disease is caused by a germline mutation in the STK11/LKB1 gene and carries an increased risk of several types of cancer, such as gastrointestinal tumors, pancreatic cancer, genital tract malignancies and, especially, breast cancer [1–2]. Approximately 50% of patients develop intussusception by the age of 15, because of jejunal and/or ileal polyps [3]. Previously, this complication was usually treated by surgery. Recently, video-capsule-endoscopy (VCE) and enteroscopy have changed both the diagnostic and the therapeutic management of small bowel hamartomas [4–8].

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References

  1. Giardiello F, Trimbath J (2006) Peutz-Jeghers syndrome and management recommendations Clinical Gastr and Hep 4:408–415

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  2. Beggs AD, Latchford AR, Vasen HFA et al (2010) Peutz Jeghers syndrome: a systematic review and recommendations for management. Gut 59:975–986

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  3. Hearle N, Schumacher V, Menko FH et al (2006) STK11 status and intussusception risk in Peutz-Jeghers syndrome. J Med Genet 43:e41–43

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  4. Brown G, Fraser C, Schofield G, Taylor S, Bartram C, Phillips R, Saunders B (2006) Video capsule endoscopy in Peutz-Jeghers syndrome: a blinded comparison with barium follow-through for detection of small-bowel polyps. Endoscopy 38:385–90

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  5. Gao H, {pavan} Lier MG, Poley JW, Kuipers EJ, {pavan} Leerdam ME, Mensink PB (2010) Endoscopic therapy of small-bowel polyps by double-balloon enteroscopy in patients with Peutz-Jeghers syndrome. Gastrointest Endosc 71:768–73

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Author information

Authors and Affiliations

  1. Endoscopy Unit, National Cancer Institute and G. Pascale Foundation, Naples, Italy

    Giovanni Battista Rossi

Authors
  1. Giovanni Battista Rossi
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  2. Giovanni Di Nardo
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  3. Mario de Bellis
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  4. Salvatore Oliva
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  5. Elena Di Girolamo
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Corresponding author

Correspondence to Giovanni Battista Rossi .

Editor information

Editors and Affiliations

  1. Department of Operative Endoscopy, Usi Group, Rome, Italy

    Antonello Trecca

Additional information

Multiple Choice Questionnaire

  1. 1)

    Peutz-Jeghers syndrome (PJS) is

    1. a.

      characterized by multiple hamartomatous polyps of the gastrointestinal tract and mucocutaneous pigmentation occurring around the body orifices

    2. b.

      associated with an increased risk of cancer

    3. c.

      an autosomal dominant disease

    4. d.

      all of the above

    5. e.

      none of the above

  2. 2)

    The most common cancer(s) associated with PJS is/are

    1. a.

      gastrointestinal tumors

    2. b.

      pancreatic cancer

    3. c.

      genital tract malignancies

    4. d.

      lung cancer

    5. e.

      breast cancer

  3. 3)

    Gastrointestinal polyps may cause

    1. a.

      gastrointestinal bleeding and anemia

    2. b.

      abdominal pain due to intussusception

    3. c.

      gastrointestinal obstruction or infarction

    4. d.

      all of the above

    5. e.

      none of the above

  4. 4)

    Which of these statements is false?

    1. a.

      VCE detects polyps less than 10 mm in diameter

    2. b.

      VCE reduces radiation exposure and is well accepted by patients

    3. c.

      balloon enteroscopy allows standard snare polypectomy of small bowel polyps

    4. d.

      therapeutic balloon enteroscopy has reduced the need for surgical resection of small bowel polyps

    5. e.

      VCE and balloon enteroscopy has not changed the current management of patients with PJS

1.d — 2.e — 3.d — 4.e

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© 2013 Springer-Verlag Italia

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Rossi, G.B., Di Nardo, G., de Bellis, M., Oliva, S., Di Girolamo, E. (2013). Videocapsule Endoscopy and Therapeutic Enteroscopy for the Management of Small Bowel Polyps in a Patient with Peutz-Jeghers Syndrome. In: Trecca, A. (eds) Atlas of Ileoscopy. Springer, Milano. https://doi.org/10.1007/978-88-470-5205-5_21

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  • DOI: https://doi.org/10.1007/978-88-470-5205-5_21

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5204-8

  • Online ISBN: 978-88-470-5205-5

  • eBook Packages: MedicineMedicine (R0)

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