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References
Klimstra DS, Modlin IR, Coppola D et al (2010) The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas 39(6):707–712
Niederle MB, Hackl M, Kaserer K, Niederle B (2010) Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. Endocr Relat Cancer 17(4):909–918
Modlin IM, Oberg K, Chung DC et al (2008) Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 9(1):61–72
Reubi JC, Schär JC, Waser B et al (2000) Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med 27(3):273–282
Krenning EP, Kwekkeboom DJ, Bakker WH et al (1993) Somatostatin receptor scintigraphy with[111In-DTPA-D-Phel]and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients. Eur J Nucl Med 20(8):716–731
Kowalski J, Henze M, Schuhmacher J et al (2003) Evaluation of positron emission tomography imaging using [68Ga]-DOTA-D Phe(1)-Tyr(3)-Octreotide in comparison to [111 In]-DTPAOC SPECT. First results in patients with neuroendocrine tumors. Mol Imaging Biol 5(1):42–48
Bombardieri E, Giammarile F, Aktolun C et al (2010) 131I/123I-metaiodobenzylguanidine (mIBG) scintigraphy: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging 37(12):2436–2446
Bombardieri E, Ambrosini V, Aktolun C et al (2010) 111In-pentetreotide scintigraphy: procedure guidelines for tumour imaging. Eur J Nucl Med Mol Imaging 37(7): 1441–1448
Virgolini I, Ambrosini V, Bomanji JB et al (2010) Procedure guidelines for PET/CT tumour imaging with 68Ga-DOTA-conjugated peptides: 68Ga-DOTA-TOC, 68Ga-DOTA-NOC, 68Ga-DOTA-TATE. Eur J Nucl Med Mol Imaging 37(10):2004–2010
Boellaard R, Delgado-Bolton R, Oyen WJ et al (2015) EV/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging 42(2):328–354
Velikyan I, Sundin A, Sörensen J et al (2014) Quantitative and qualitative intrapatient comparison of 68Ga-DOTATOC and 68Ga-DOTATATE: net uptake rate for accurate quantification. J Nucl Med 55(2):204–210
Baum RP, Kulkarni HR (2012) THERANOSTICS: from molecular imaging using Ga-68 labeled tracers and PET/CT to personalized radionuclide therapy — The Bad Berka Experience. Theranostics 2(5):437–447
Koopmans KP, de Vires EG, Kema IP et al (2006) Staging of carcinoid tumor with [18F] DOPA PET: a prospective diagnostic accuracy study. Lancet Oncol 7(9):728–734
Ambrosini V, Tomassetti P, Rubello D et al (2007) Role of [18F]Dopa PET/CT imaging in the management of patients with 111In pentetreotide negative GEP tumors. Nucl Med Commun 28(6):473–477
Treglia G, Cocciolillo F, de Waure C et al (2012) Diagnostic performance of 18F-dihydroxyphenylalanine positron emission tomography in patients with paraganglioma: a metaanalysis. Eur J Nucl Med Mol Imaging 39(7): 1144–1153
Kroiss A, Putzer D, French A et al (2013) A retrospective comparison between 68Ga-DOTA-TOC PET/CT and 18F-DOPA PET/CT in patients with extra-adrenal paraganglioma. Eur J Nucl Med Mol Imaging 40(12): 1800–1808
Havekes B, Lai EW, Corssmit EP et al (2008) Detection and treatment of pheochromocytomas and paragangliomas: current standing of MIBG scintigraphy and future role of PET imaging. Q J Nucl Med Mol Imaging 52(4):419–429
Wieland DM, Wu J, Brown LE et al (1980) Radiolabeled adrenergic neuron-blocking agents: adrenomedullary imaging with [131I]iodobenzylguanidine. J Nucl Med 21(4):349–353
Sisson JC, Shapiro B, Beierwaltes WH et al (1984) Radiopharmaceutical treatment of 30 malignant pheochromocytoma. J Nucl Med 25(2): 197–206
Furuta N, Kiyota H, Yoshigoe F et al (1999). Diagnosis of pheochromocytoma using [123I]-46 compared with [131I]-metaiodobenzylguanidine scintigraphy. Int J Urol 6:228–247
Shapiro B, Gross MD, Shulkin B (2001) Radioisotope diagnosis and therapy of malignant pheochromocytoma. Trends Endocrinol Metab 12(10):469–475
Bhatia KS, Ismail MM, Sahdev A et al (2008) 123I-metaiodobenzylguanidine 1 (MIBG) scintigraphy for the detection of adrenal and extra-adrenal phaeochromocytomas: CT and MRI correlation. Clin Endocrinol (Oxford) 69(2): 181–188
Timmers HJ, Kozupa A, Chen CC et al (2007) Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma. J Clin Oncol 25(16): 2262–2269
Milardovic R, Corssmit EP, Stokkel M (2010) Value of 123I-MIBG scintigraphy in paraganglioma. Neuroendocrinology 91(1):94–100
Naji M, Zhao C, Welsh SJ et al (2011) 68Ga-DOTA-TATE PET vs. 123I-MIBG in identifying malignant neural crest tumours. Mol Imaging Biol 13(4):769–775
Naji M, Al-Nahhas A (2012) Ga-labelled peptides in the management of neuroectodermal tumours. Eur J Nucl Med Mol Imaging 39(Suppl 1):S61–S67
Safford SD, Coleman RE, Gockerman JP et al (2004) Iodine 131 metaiodobenzylguanidine treatment for metastatic carcinoid. Results in 98 patients. Cancer 101(9): 1987–1993
Khan MU, Morse M, Coleman RE (2008) Radioiodinated metaiodobenzylguanidine in the diagnosis and therapy of carcinoid tumors. Q J Nucl Med Mol Imaging 52(4):441–454
Buscombe JR, Cwikla JB, Caplin MR et al (2005) Long-term efficacy of low activity meta-[131I]iodobenzylguanidine therapy in patients with disseminated neuroendocrine tumors depends on initial response. Nucl Med Commun 26(11):969–976
Binderup T, Knigge U, Loft A et al (2010) 18F-fluorodeoxyglucose positron emission tomography predicts survival of patients with neuroendocrine tumors. Clin Cancer Res 16(3):978–985
Severi S, Nanni O, Bodei L et al (2013) Role of 18FDG PET/CT in patients treated with 177Lu-DOTATATE for advanced differentiated neuroendocrine tumours. Eur J Nucl Med Mol Imaging 40(6):881–888
Kwee TC, Basu S, Saboury B et al (2011) A new dimension of FDG-PET interpretation: assessment of tumor biology. Eur J Nucl Med Mol Imaging 38(6): 1158–1170
Sansovini M, Severi S, Ianniello A et al (2017) Long-term follow-up and role of FDG PET in advanced pancreatic neuroendocrine patients treated with 177Lu-DOTATATE. Eur J Nucl Med Mol Imaging 44(3):490–499
Sundin A, Eriksson B, Bergström M et al (2000) Demonstration of [11C] 5-hydroxy-L-tryptophan uptake and decarboxylation in carcinoid tumors by specific positioning labeling in positron emission tomography. Nucl Med Biol 27(1):33–41
Krenning EP, Bakker WH, Breeman WA et al (1989) Localisation of endocrine-related tumours with radioiodinated analogue of somatostatin. Lancet 1(8632):242–244
Gibril F, Reynolds JC, Doppman JL et al (1996) Somatostatin receptor scintigraphy: its sensitivity compared with that of other imaging methods in detecting primary and metastatic gastrinomas. A prospective study. Ann Intern Med 125(1):26–34
Chiti A, Fanti S, Savelli G et al (1998) Comparison of somatostatin receptor imaging computed tomography and ultrasound in the clinical management of neuroendocrine gastroentero-pancreatic tumours. Eur J Nucl Med 25(10): 1396–1403
Kwekkeboom DJ, Kam BL, van Essen M et al (2010) Somatostatin-receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors. Endocr Relat Cancer 17(1):R53–R73
Valkema R, De Jong M, Bakker WH et al (2002) Phase I study of peptide receptor radionuclide therapy with [In-DTPA] octreotide: the Rotterdam experience. Semin Nucl Med 32(2): 110–122
Kwekkeboom DJ, Teunissen JJ, Bakker WH et al (2005) Radiolabeled somatostatin analog [177Lu-DOTA0,Tyr3]octreotate in patients with endocrine gastroenteropancreatic tumors. J Clin Oncol 23 (12):2754–2762
Reubi JC, Waser B (2003) Concomitant expression of several peptide receptors in neuroendocrine tumours: molecular basis for in vivo multireceptor tumour targeting. Eur J Nucl Med Mol Imaging 30(5):781–793
Ambrosini V, Campana D, Tomassetti P, Fanti S (2012) 68Ga-labelled peptides for diagnosis of gastroenteropancreatic NET. Eur J Nucl Med Mol Imaging 39(Suppl 1):S52–S60
Castellucci P, Pou Ucha J, Fuccio C et al (2011) Incidence of increased 68Ga-DOTANOC uptake in the pancreatic head in a large series of extrapancreatic NET patients studied with sequential PET/CT. J Nucl Med 52(6):886–890
Haug AR, Auernhammer CJ, Wängler B et al (2010) 68Ga-DOTATATE PET/CT for the early prediction of response to somatostatin receptor-mediated radionuclide therapy in patients with well-differentiated neuroendocrine tumors. J Nucl Med 51(9): 1349–1356
Gabriel M, Decristoforo C, Kendler D et al (2007) 68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT. J Nucl Med 48(4):508–518
Srirajaskanthan R, Kayani I, Quigley AM et al (2010) The role of 68Ga DOTATATE PET in patients with neuroendocrine tumor and negative or equivocal finding on 111In-DTPA-octreotide scintigraphy. J Nucl Med 51(6):875–882
Prasad V, Ambrosini V, Homman M et al (2010) Detection of unknown primary neuroendocrine tumours (CUP-NET) using (68)Ga-DOTA-NOC receptor PET/CT. Eur J Nucl Med Mol Imaging 37(1):67–77
Strosberg J, El-Haddad G, Wolin E et al (2017). Phase 3 trial of 177Lu-DOTATE for midgut neuroendocrine tumors. N Engl J Med 376(2): 125–135
Johnbeck CB, Knigge U, Loft A et al (2017) Head-to-head comparison of 64Cu-DOTATATE and 68Ga-DOTATOC PET/CT: a prospective study of 59 patients with neuroendocrine tumors. J Nucl Med 58(3):451–457
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Severi, S., Paganelli, G. (2018). Role of Functional Imaging in the Diagnosis of Neuroendocrine Tumors. In: Carlini, M. (eds) Abdominal Neuroendocrine Tumors. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-3955-1_8
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DOI: https://doi.org/10.1007/978-88-470-3955-1_8
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