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Abdominal Neuroendocrine Tumors pp 21–32Cite as

Classification of Abdominal Neuroendocrine Tumors

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Part of the book series: Updates in Surgery ((UPDATESSURG))

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References

  1. Bosman F, Carneiro F, Hruban R, Theise ND (2010) WHO classification of tumours of the digestive system, 4th edn. IARC Press, Lyon

    Google Scholar 

  2. Rindi G, Petrone G, Inzani F (2014) The 2010 WHO classification of digestive neuroendocrine neoplasms: a critical appraisal four years after its introduction. Endocr Pathol 25(2): 186–192

    Article  CAS  PubMed  Google Scholar 

  3. Rindi G, Wiedenmann B (2011) Neuroendocrine neoplasms of the gut and pancreas: new insights. Nat Rev Endocrinol 8(1):54–64

    Article  PubMed  Google Scholar 

  4. Falkmer S (1993) Phylogeny and ontogeny of the neuroendocrine cells of the gastrointestinal tract. Endocrinol Metab Clin North Am 22(4):731–752

    CAS  PubMed  Google Scholar 

  5. Rindi G, Grant SG, Yiangou Y et al (1990) Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Am J Pathol 136(6): 1349–1363

    CAS  PubMed  Google Scholar 

  6. Schonhoff SE, Giel-Moloney M, Leiter AB (2004) Minireview: development and differentiation of gut endocrine cells. Endocrinology 145(6):2639–2644

    Article  CAS  PubMed  Google Scholar 

  7. Capella C, Heitz PU, Hofler H et al (1995) Revised classification of neuroendocrine tumours of the lung, pancreas and gut. Virchows Arch 425(6):547–560

    Article  CAS  PubMed  Google Scholar 

  8. Yang Z, Tang LH, Klimstra DS (2013) Gastroenteropancreatic neuroendocrine neoplasms: historical context and current issues. Semin Diagn Pathol 30(3): 186–196

    Article  PubMed  Google Scholar 

  9. Shi C, Klimstra DS (2014) Pancreatic neuroendocrine tumors: pathologic and molecular characteristics. Semin Diagn Pathol 31(6):498–511

    Article  PubMed  Google Scholar 

  10. Klimstra DS (2016) Pathologic classification of neuroendocrine neoplasms. Hematol Oncol Clin North Am 30(1):1–19

    Article  PubMed  Google Scholar 

  11. Kloppel G, Heitz PU (1988) Pancreatic endocrine tumors. Pathol Res Pract 183(2): 155–168

    Article  CAS  PubMed  Google Scholar 

  12. La Rosa S, Sessa F, Uccella S (2016) Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs): unifying the concept of a heterogeneous group of neoplasms. Endocr Pathol 27(4):284–311

    Article  PubMed  Google Scholar 

  13. Solcia E, Kloppel G, Sobin L (2000) Histological typing of endocrine tumours. Springer, New York

    Book  Google Scholar 

  14. De Lellis R, Lloyd R, Heitz P et al (2004) Pathology and genetics of tumours of endocrine organs. IARC Press, Lyon

    Google Scholar 

  15. Modlin IM, Oberg K, Chung DC et al (2008) Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 9(1):61–72

    Article  CAS  PubMed  Google Scholar 

  16. Pelosi G, Pattini L, Morana G et al (2017) Grading lung neuroendocrine tumors: controversies in search of a solution. Histol Histopathol 32(3):223–241

    PubMed  Google Scholar 

  17. Pelosi G, Bresaola E, Bogina G et al (1996) Endocrine tumors of the pancreas: Ki-67 immunoreactivity on paraffin sections is an independent predictor for malignancy: a comparative study with proliferating-cell nuclear antigen and progesterone receptor protein immunostaining, mitotic index, and other clinicopathologic variables. Hum Pathol 27(11):1124–1134

    Article  CAS  PubMed  Google Scholar 

  18. Pelosi G, Fabbri A, Cossa M et al (2015) What clinicians are asking pathologists when dealing with lung neuroendocrine neoplasms? Semin Diagn Pathol 32(6):469–479

    Article  PubMed  Google Scholar 

  19. Klimstra DS, Modlin IR, Adsay NV et al (2010) Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data set. Am J Surg Pathol 34(3):300–313

    Article  PubMed  Google Scholar 

  20. Sorbye H, Strosberg J, Baudin E et al (2014) Gastroenteropancreatic high-grade neuroendocrine carcinoma. Cancer 120(18):2814–2823

    Article  CAS  PubMed  Google Scholar 

  21. Sampietro G, Tomasic G, Collini P et al (2000) Gene product immunophenotyping of neuroendocrine lung tumors. No linking evidence between carcinoids and small-cell lung carcinomas suggested by multivariate statistical analysis. Appl Immunohistochem Mol Morphol 8(1):49–56

    CAS  PubMed  Google Scholar 

  22. Pelosi G, Masullo M, Leon ME et al (2004) CD117 immunoreactivity in high-grade neuroendocrine tumors of the lung: a comparative study of 39 large-cell neuroendocrine carcinomas and 27 surgically resected small-cell carcinomas. Virchows Arch 445(5):449–455

    Article  PubMed  Google Scholar 

  23. Klimstra DS (2013) Pathology reporting of neuroendocrine tumors: essential elements for accurate diagnosis, classification, and staging. Semin Oncol 40(1):23–36

    Article  PubMed  Google Scholar 

  24. Klimstra DS, Modlin IR, Coppola D et al (2010) The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas 39(6):707–712

    Article  PubMed  Google Scholar 

  25. Kloppel, G, Rindi, G, Anlauf, M et al (2007) Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors. Virchows Arch 451 Suppl 1:S9–S27

    Article  PubMed  Google Scholar 

  26. Rindi G, Kloppel G, Alhman H et al (2006) TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 449(4):395–401

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Rindi G, Kloppel G, Couvelard A et al (2007) TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch 451(4):757–762

    Article  CAS  PubMed  Google Scholar 

  28. Vinik AI, Woltering EA, Warner RR et al (2010) NANETS consensus guidelines for the diagnosis of neuroendocrine tumor. Pancreas 39(6):713–734

    Article  PubMed  Google Scholar 

  29. Pelosi G, Zamboni G, Doglioni C et al (1992) Immunodetection of proliferating cell nuclear antigen assesses the growth fraction and predicts malignancy in endocrine tumors of the pancreas. Am J Surg Pathol 16(12): 1215–1225

    Article  CAS  PubMed  Google Scholar 

  30. Rindi G, Falconi M, Klersy C et al (2012) TNM staging of neoplasms of the endocrine pancreas: results from a large international cohort study. J Natl Cancer Inst 104(10):764–777

    Article  CAS  PubMed  Google Scholar 

  31. Pelosi G, Rindi G, Travis WD et al (2014) Ki-67 antigen in lung neuroendocrine tumors: unraveling a role in clinical practice. J Thorac Oncol 9(3):273–284

    Article  CAS  PubMed  Google Scholar 

  32. Fabbri A, Cossa M, Sonzogni A et al (2017) Ki-67 labeling index of neuroendocrine tumors of the lung has a high level of correspondence between biopsy samples and surgical specimens when strict counting guidelines are applied. Virchows Arch 470(2): 153–164

    Article  CAS  PubMed  Google Scholar 

  33. Yang Z, Tang LH, Klimstra DS (2011) Effect of tumor heterogeneity on the assessment of Ki67 labeling index in well-differentiated neuroendocrine tumors metastatic to the liver: implications for prognostic stratification. Am J Surg Pathol 35(6):853–860

    Article  PubMed  Google Scholar 

  34. Tang LH, Gonen M, Hedvat C et al (2012) Objective quantification of the Ki67 proliferative index in neuroendocrine tumors of the gastroenteropancreatic system: a comparison of digital image analysis with manual methods. Am J Surg Pathol 36(12): 1761–1770

    Article  PubMed  Google Scholar 

  35. Rindi G, Klersy C, Inzani F et al (2014) Grading the neuroendocrine tumors of the lung: an evidence-based proposal. Endocr Relat Cancer 21(1): 1–16

    Article  CAS  PubMed  Google Scholar 

  36. Volante M, Daniele L, Asioli S et al (2013) Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases. Am J Surg Pathol 37(4):606–612

    Article  PubMed  Google Scholar 

  37. Scarpa A, Mantovani W, Capelli P et al (2010) Pancreatic endocrine tumors: improved TNM staging and histopathological grading permit a clinically efficient prognostic stratification of patients. Mod Pathol 23(6):824–833

    Article  CAS  PubMed  Google Scholar 

  38. Basturk O, Tang L, Hruban RH et al (2014) Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases. Am J Surg Pathol 38(4):437–447

    Article  PubMed  PubMed Central  Google Scholar 

  39. Basturk O, Yang Z, Tang LH et al (2015) The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms. Am J Surg Pathol 39(5):683–690

    Article  PubMed  PubMed Central  Google Scholar 

  40. Tang LH, Basturk O, Sue JJ, Klimstra DS (2016) A practical approach to the classification of WHO grade 3 (G3) well-differentiated neuroendocrine tumor (WD-NET) and poorly differentiated neuroendocrine carcinoma (PD-NEC) of the pancreas. Am J Surg Pathol 40(9): 1192–1202

    Article  PubMed  PubMed Central  Google Scholar 

  41. Raj N, Valentino E, Capanu M et al (2016) Treatment response and outcomes of grade 3 pancreatic neuroendocrine neoplasms based on morphology: well differentiated versus poorly differentiated. Pancreas 46(3):296–301

    Article  Google Scholar 

  42. Tang LH, Untch BR, Reidy DL et al (2016) Well-differentiated neuroendocrine tumors with a morphologically apparent high-grade component: a pathway distinct from poorly differentiated neuroendocrine carcinomas. Clin Cancer Res 22(4): 1011–1017

    Article  CAS  PubMed  Google Scholar 

  43. Fabbri A, Cossa M, Sonzogni A et al (2017) Thymus neuroendocrine tumors with CTNNB1 gene mutations, disarrayed β-catenin expression, and dual intra-tumor Ki-67 labeling index compartmentalization challenge the concept of secondary high-grade neuroendocrine tumor: a paradigm shift. Virchows Arch [Epub ahead of print] doi: 10.1007/s00428-017-2130-2

    Google Scholar 

  44. Travis W, Brambilla E, Burke A et al (2015) WHO classification of tumours of the lung, pleura, thymus and hearth, 4th edn. IARC Press, Lyon

    Google Scholar 

  45. Pelosi G, Rodriguez J, Viale G, Rosai J (2005) Typical and atypical pulmonary carcinoid tumor overdiagnosed as small-cell carcinoma on biopsy specimens: a major pitfall in the management of lung cancer patients. Am J Surg Pathol 29(2): 179–187

    Article  PubMed  Google Scholar 

  46. McCall CM, Shi C, Cornish TC et al (2013) Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate. Am J Surg Pathol 37(11): 1671–1677

    Article  PubMed  PubMed Central  Google Scholar 

  47. Travis WD, Brambilla E, Nicholson AG et al (2015) The 2015 World Health Organization classification of lung tumors: impact of genetic, clinical and radiologic advances since the 2004 classification. J Thorac Oncol 10(9): 1243–1260

    Article  PubMed  Google Scholar 

  48. Hochwald SN, Zee S, Conlon KC et al (2002) Prognostic factors in pancreatic endocrine neoplasms: an analysis of 136 cases with a proposal for low-grade and intermediate-grade groups. J Clin Oncol 20(11):2633–2642

    Article  PubMed  Google Scholar 

  49. Remes SM, Tuominen VJ, Helin H et al (2012) Grading of neuroendocrine tumors with Ki-67 requires high-quality assessment practices. Am J Surg Pathol 36(9): 1359–1363

    Article  PubMed  Google Scholar 

  50. Caplin ME, Baudin E, Ferolla P et al (2015) Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids. Ann Oncol 26(8): 1604–1620

    Article  CAS  PubMed  Google Scholar 

  51. Kim BS, Park YS, Yook JH, Kim BS (2016) Comparison of the prognostic values of the 2010 WHO classification, AJCC 7th edition, and ENETS classification of gastric neuroendocrine tumors. Medicine (Baltimore) 95(30):e3977

    Article  CAS  Google Scholar 

  52. Martin RC, Kooby DA, Weber SM et al (2011) Analysis of 6,747 pancreatic neuroendocrine tumors for a proposed staging system. J Gastrointest Surg 15(1): 175–183

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

    Giuseppe Pelosi

  2. Interhospital Pathology Division, Science & Technology Park, IRCCS MultiMedica, Milan, Italy

    Giuseppe Pelosi

Authors
  1. Erminia Manfrin
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  2. Angelica Sonzogni
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  3. Aldo Scarpa
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  4. Giuseppe Pelosi
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Corresponding author

Correspondence to Giuseppe Pelosi .

Editor information

Editors and Affiliations

  1. Department of Surgery, Division of General Surgery, S. Eugenio Hospital, Rome, Italy

    Massimo Carlini

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Manfrin, E., Sonzogni, A., Scarpa, A., Pelosi, G. (2018). Classification of Abdominal Neuroendocrine Tumors. In: Carlini, M. (eds) Abdominal Neuroendocrine Tumors. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-3955-1_2

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  • DOI: https://doi.org/10.1007/978-88-470-3955-1_2

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-3954-4

  • Online ISBN: 978-88-470-3955-1

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