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Imaging of Malignant Focal Liver Lesions

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MRI of the Liver

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Abstract

Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and one of the most prevalent visceral malignances worldwide [31]. HCC often occurs in patients with liver cirrhosis for which the cause is known (e.g. chronic viral hepatitis or alcoholism) [47]. However, whereas in Asia HCC occurs almost exclusively in patients with chronic liver damage from hepatitis, in North America many patients develop HCC without cirrhosis or known risk factors [100]. In these latter patients it is possible that steroid hormones may play a role in carcinogenesis, as tumors occurring in non-cirrhotic livers have been associated with the use of exogeneous steroids such as anabolic steroids and oral contraceptives, as well as with genetic factors [70]. Environmental and dietary factors are known to play major etiological roles, while aflatoxins, nitrosamines, and other chemical carcinogens have also been implicated in non-cirrhotic HCC [25, 32].

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References

  1. Agarwal VR, Takayama K, Van Wyk JJ, Sasano H, Simpson ER, Bulun SE. Molecular basis of severe gynecomastia associated with aromatase expression in fibrolamellar hepatocellular carcinoma. J Clin Endocrinol Metab 1998; 83: 1797–1800.

    PubMed  CAS  Google Scholar 

  2. Andrcu V, Elizalde 1, Mallafre C, Caballeria J, Salmeron JM, Sans M, Mas A, Bruguera M, Rods J. Plexiform neurofibromatosis and angiosarcoma of the liver in von Recklinghausen Disease. Am J Gastroenterol 1997; 92: 1229–1230.

    Google Scholar 

  3. Baker ME, Paulson EK. Hepato metastatic disease. In Meyers M.A., ed. Neoplasms of the digestive tract: imaging, staging, and management. Philadelphia: Lippincott-Raven; 1998: 361–395.

    Google Scholar 

  4. Bates SM, Keller MS, Ramos IM, Carter D, Taylor KJ. Hepatoblastoma: detection of tumor vascularity with Duplex Doppler US. Radiology 1990; 176: 505–507.

    PubMed  CAS  Google Scholar 

  5. Berk RN. Armbustcr TG, Saltztein SL. Carcinoma in the porcelain gallbladder. Radiology 1973; 106:29–31.

    Google Scholar 

  6. Berman MM, Libbey NP, Foster JH. Hepatocellular carcinoma: polygonal cell type with fibrous stroma–an atypical variant with a favorable prognosis. Cancer 1980; 46: 1448–1455.

    PubMed  CAS  Google Scholar 

  7. Biemer JJ. Hepatic manifestation of lymphoma. Ann Clin Lab 1984; 14: 252–260.

    CAS  Google Scholar 

  8. Bluemke DA. Soyer P, Fishman E. Helical (spiral) CT of the liver. Radiol Clin North Am 1995; 33:863–885.

    Google Scholar 

  9. Brady J, Liberatore F, Harper P, Greenwald P, Burnett W, Davies JN, Bishop M, Polan A, Vianna N. Angiosarcoma of the liver: an epidemiology survey. J Nati Cancer Inst 1977; 59: 1383–1385.

    CAS  Google Scholar 

  10. Brandt DJ, Johnson CD, Stephens DH, Weiland LH. Imaging of fibrolamellar hepatocellular carcinoma. AJR 1988; 151: 295–299.

    PubMed  CAS  Google Scholar 

  11. Buetow PC, Buck JL, Ros PR, Goodman ZD. Malignant vascular tumors of the liver: radiologic-pathologic correlation. Radiographies 1994; 14: 153–166.

    CAS  Google Scholar 

  12. Buetow PC, Buck JL, Pantongrag-Brown L. Marshall WH, Ros PR, Levine MS, Goodman ZD. Undifferentiated (embryonal) sarcoma of the liver: pathologic basis of imaging findings in 28 cases. Radiology 1997: 203: 779–783.

    PubMed  CAS  Google Scholar 

  13. Caillaud JM, Gerard-Marchant R, Marsden HB, van Unnik AJ, Rodary C. Rey A, Flamant F. Histopathological classification of childhood rhabdomyosarcoma: a report from the International Society of Pediatric Oncology pathology panel. Med Pediatr Oncol 1989; 17: 391–400.

    PubMed  CAS  Google Scholar 

  14. Campbell WL, Ferris J V, Holbert BL, Thaete FL, Baron RL. Biliary tract carcinoma complicating primary sclerosing cholangitis: evaluation with CT, cholangiography, US, and MR imaging. Radiology 1998; 207: 41–50.

    PubMed  CAS  Google Scholar 

  15. Carceller A, Blanchard H, Champagne J, St-Vil D, Bensoussan AL. Surgical resection and chemother-apy improve survival rate for patients with hepatoblastoma. J Ped Surg, 2001; 36: 755–759.

    CAS  Google Scholar 

  16. Cariaga MT, Henson DE. Liver, gallbladder, extrahepatic bile ducts, and pancreas. Cancer 1995; 75: 171–190.

    Google Scholar 

  17. Caty MG, Oldham KT, Prochownik EV. Embryonal rhabdomyosarcoma of the ampulla of Vater with long-term survival following pancreaticoduodenectomy. J Pediatr Surg 1990; 25: 1256–1258.

    PubMed  CAS  Google Scholar 

  18. Caudana R, Morana G, Pirovano GP, Nicoli N, Portuese A, Spinazzi A, Di Rito R, Pistolesi GL. Focal malignant hepatic lesions: MR imaging enhanced with Gadolinium Benzyloxypropionictetra-acetate (BOPTA)-preliminary results of phase II clinical application. Radiology 1996; 199: 513–521.

    PubMed  CAS  Google Scholar 

  19. Chen IY, Katz DS, Jeffrey RB Jr, Daniel BL, Li KC, Beaulieu CF, Mindelzun RE, Yao D, Olcott EW. Do arterial phase helical CT images improve detection or characterization of colorectal liver metastases?. Comput Assist Tomogr 1997; 21 (3): 391–397.

    CAS  Google Scholar 

  20. Chiao R. Mo L, Hall A. et al.. B-mode blood flow imaging. ALUM Annual Convention, San Francisco, California, USA, April 2–5 2000.

    Google Scholar 

  21. Choi Bl. Kim CW, Han MC, Kim CY, Lee HS, Kim ST, Kim Yl. Sonographie characteristic of small hepatocellular carcinoma. Gastrointestinal Radiol. 1989; 14: 25–261.

    Google Scholar 

  22. Choi BI, Takayasu K, Han MC. Small hepatocellular carcinomas and associated nodular lesions of the liver: pathology. pathogenesis, and imaging findings. AJR 1993; 160: 1177–1187.

    PubMed  CAS  Google Scholar 

  23. Choi BI, Han JK, Hong SH, Kim TK, Song CS, Kim KW, Kim MJ, Han MC. Dysplastic nodules of the liver: imaging findings. Abdom Imaging 1999; 24: 250–257.

    PubMed  CAS  Google Scholar 

  24. Coffey RJ, Wiesner RH, Beaver SJ, et al.. Bile duct carcinoma: a late complication of end-stage primary sclerosing cholangitis. Hepatology 1984; 14: 1056–1059.

    Google Scholar 

  25. Collier JD, Carpenter M, Burt AD, Bassendine MF. Expression of mutant p53 protein in hepatocellular carcinoma. Gut 1991: 35: 98–100.

    Google Scholar 

  26. Corrigan K, Semelka RC. Dynamic contrast-enhanced MR imaging of fibrolamellar hepatocellular carcinoma. Abdom Imaging 1995: 20: 122–125.

    PubMed  CAS  Google Scholar 

  27. Craig JR. Mesenchymal tumors of the liver. Diagnostic problems for the surgical pathologist. Pathology 1994; 3: 141–160.

    PubMed  CAS  Google Scholar 

  28. Craig JR, Peters RL, Edmondson HA, Omata M. Fibrolamellar carcinoma of the liver: a tumor of ado-lescents and young adults with distinctive clinicopathologic features. Cancer 1980; 46: 372–379.

    PubMed  CAS  Google Scholar 

  29. Dachman AH, Pakter RL, Ros PR, Fishman EK, Goodman ZD, Lichtenstein JE. Hepatoblastoma: radiologic-pathologic correlation in 50 cases. Radiology 1987; 164: 15–19.

    PubMed  CAS  Google Scholar 

  30. Davey MS, Cohen MD. Imaging of gastrointestinal malignancy in childhood. Radiol Clin North Am. 1996; 34: 717–742.

    PubMed  CAS  Google Scholar 

  31. Del Pilar F, Redvanley RD. Primary hepatic malignant neoplasms. Radiol Clin North Am 1998; 36: 333348.

    Google Scholar 

  32. Enwonwu CO. The role of dietary aflatoxin in the genesis of hepatocellular cancer in the developing countries. Lancet 1984; 2: 956–958.

    PubMed  CAS  Google Scholar 

  33. Freeny PC, Baron RL, Teefey SA. Hepatocellular carcinoma: reduced frequency of typical findings with dynamic contrast-enhanced CT in a non-Asian population. Radiology 1992; 182: 143–148.

    PubMed  CAS  Google Scholar 

  34. Friedburg H, Kauffmann GW, Bohm N, Fiedler L, Jobke A. Sonographic and computed tomographic features of embryonal rhabdomyosarcoma of the biliary tract. Pediatr Radiol 1984; 14: 436–438.

    PubMed  CAS  Google Scholar 

  35. Friedman AC, Lichtenstein JE, Goodman Z, Fishman EK, Siegelman SS, Dachman AH. Fibrolamellar hepatocellular carcinoma. Radiology 1985; 157: 583–587.

    PubMed  CAS  Google Scholar 

  36. Fukayama M, Nihei Z, Takizawa T, Kawaguchi K, Harada H, Koike M. Malignant epithelioid hemangioendothelioma of the liver, spreading through the hepatic veins. Virchiws Arch A Pathol Anat Histopathol 1984; 404: 275–287.

    CAS  Google Scholar 

  37. Furui S, Itai Y, Ohtomo K, Yamauchi T, Takenaka E, Iio M, Ibukuro K, Shichijo Y, Inoue Y. Hepatic epithelioid hemangioendothelioma: report of five cases. Radiology 1989; 171: 63–68.

    PubMed  CAS  Google Scholar 

  38. Gabata T, Matsui O, Kadoya M, Yoshikawa J, Ueda K, Kawamori Y, Takashima T, Nonomura A. Delayed MR imaging of the liver: correlation of delayed enhancement of hepatic tumors and pathologic appearance. Abdom Imaging 1998; 9: 167–182.

    Google Scholar 

  39. Garber SJ, Donald JJ, Lees WR. Cholangiocarcinoma: ultrasound features and correlation with survival. Abdom Imaging 1993; 18: 66–69.

    PubMed  CAS  Google Scholar 

  40. Geoffray A, Couanet D, Montagne JP, Ledere J, Flamant F. Ultrasonography and computed tomography for diagnosis and follow-up of biliary tract rhabdomyosarcomas in children. Pediatr Radiol 1987; 17: 127–131.

    PubMed  CAS  Google Scholar 

  41. Goodman ZD. Nonparenchymal and metastatic malignant tumors of the liver. In Haubrich W.S., Schaffner F, Berk J.E. (eds): Bockus Gastroenterology. Philadelphia: WB Saunders, 1995; pp 24882500.

    Google Scholar 

  42. Grazioli L, Olivetti L, Fugazzola C, Benetti A, Stanga C, Dettori E, Gallo C, Matricardi L, Giacobbe A, Chiesa A. The pseudocapsule in hepatocellular carcinoma: correlation between dynamic MR imaging and pathology. Eur Radiol 1999; 9: 62–67.

    PubMed  CAS  Google Scholar 

  43. Grazioli L, Morana G, Caudana R, Benetti A, Portolani N, Talamini G, Colombari R, Pirovano G, Kirchin MA, Spinazzi A..: Hepatocellular carcinoma. Correlation between gadobenate Dimeglumineenhanced MRI and pathologic findings. Invest Radiol 2000; 35 (1): 25–34.

    PubMed  CAS  Google Scholar 

  44. Gupta S, Udupa KN, Gupta S. Primary carcinoma of the gallbladder: a review of 328 cases. J Surg On-col 1980; 14: 35–44.

    CAS  Google Scholar 

  45. Hagspiel KD, Neidl KF, Eichenberger AC, Weder W, Marincek B. Detection of liver metastases: comparison of superparamagnetic Iron Oxide-enhanced and unenhanced MR imaging at 1.5 T with dynamic CT, intraoperative US, and percutanous US. Radiology 1995; 196: 471–478.

    PubMed  CAS  Google Scholar 

  46. Haliloglu M, Hoffer FA, Gronemeyer SA, Furman WL, Shochat SJ. 3D Gadolinium-enhanced MRA: evaluation of hepatic vasculature in children with hepatoblastoma. J Magn Reson Imaging 2000; 11: 6568.

    Google Scholar 

  47. Hardell L, Bengtsson NO, Jonsson U, Eriksson S, Larsson LG. Aetiological aspects of primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria — an epidemiological investigation. Br J Cancer 1984; 50: 389–397.

    PubMed  CAS  Google Scholar 

  48. Hayashi M, Matsui O, Ueda K, Kawamori Y, Kadoya M, Yoshikawa J, Gabata T, Takashima T, Nono-mura A, Nakanuma Y. Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: evaluation by CT during intraarterial injection of contrast medium. AJR 1999; 172: 969–976.

    PubMed  CAS  Google Scholar 

  49. Helmberger TK, Ros PR, Mergo PJ, Tomczak R, Reiser MF. Pediatric liver neoplasms: a radiologicpathologic correlation. Eur Radiol 1999; 9: 1339–1347.

    PubMed  CAS  Google Scholar 

  50. Hollett MD, Jeffrey RB Jr, Nino-Murcia M, Jorgensen MJ, Harris DP. Dual phase helical CT of the liver: value of arterial-phase scans in the detection of small (1.5 cm) malignant hepatic neoplasms. AJR 1995; 164: 879–884.

    PubMed  CAS  Google Scholar 

  51. Horn RC, Enterline HT. Rhabdomyosarcoma: a clinicopathological study and classification of 39 cases. Cancer 1958; 11: 181–199.

    PubMed  Google Scholar 

  52. Horowitz ME, Etcubanas E, Webber BL, Kun LE, Rao BN, Vogel RJ, Pratt CB. Hepatic undifferentiated (embryonal) sarcoma and rhabdomyosarcoma in children. Cancer 1987; 59: 396–402.

    PubMed  CAS  Google Scholar 

  53. Ichikawa T, Federle MP, Grazioli L, Madariaga J, Nalesnik M, Marsh W. Fibrolamellar hepatocellular carcinoma: imaging and pathologic findings in 31 recent cases. Radiology 1999; 213: 352–361.

    PubMed  CAS  Google Scholar 

  54. Imai Y, Murakami T, Yoshida S, Nishikawa M, Ohsawa M, Tokunaga K, Murata M, Shibata K, Zushi S, Kurokawa M, Yonezawa T, Kawata S, Takamura M, Nagano H, Sakon M, Monden M, Wakasa K

    Google Scholar 

  55. Nakamura H. Superparamagnetic iron oxide-enhanced magnetic resonance images of hepatocellular carcinoma: correlation with histological grading. Hepatology 2000; 32: 205–212.

    PubMed  Google Scholar 

  56. Ishak KG. Mesenchymal tumors of the liver. In Okuda K, Peter R.L. (eds): Hepatocellular Carcinoma. New York: John Wiley e Sons, 1976, pp 228–587.

    Google Scholar 

  57. Ishak KG. Pathogenesis of liver diseases. In Farber E, Philips M.J., Kaufman N (eds): International Academy of Phatology Monograph, No. 28. Baltimore: Williams and Wilkins, 1987, pp 314–315.

    Google Scholar 

  58. Ishak KG, Sesterhenn IA, Goodman ZD, Rabin L, Stromeyer FW. Epithelioid hemangioendothelioma of the liver: a clinicopathologic and follow-up study of 32 cases. Hum pathol 1984; 15: 839–852.

    PubMed  CAS  Google Scholar 

  59. Itai Y, Matsui O. Blood flow and liver imaging. Radiology 1997; 202: 306–314.

    PubMed  CAS  Google Scholar 

  60. Ito Y, Loijiro M, Nakshima T, et al. Pathomorphologic characteristics of 102 cases of thorotrast-related hepatocellular carcinoma, cholangiocarcinoma, and hepatic angiosarcoma. Cancer 1988; 62: 1153 1162.

    Google Scholar 

  61. Jaffe ES: Malignant lymphoma: pathology of hepatic involvement. Semin Liver Dis 1987; 7: 257–268.

    PubMed  CAS  Google Scholar 

  62. Jang HJ, Lim HK, Lee WJ, Kim SH, Kim KA, Kim EY. Ultrasonographic evaluation of focal hepatic lesions: comparison of pulse inversion harmonic, tissue harmonic, and conventional imaging techniques. J Ultrasound Med 2000; 19: 293–299.

    PubMed  CAS  Google Scholar 

  63. Joshi SW, Merchant NH, Jambhekar NA. Primary multilocular cystic undifferentiated (embryonal) sarcoma of the liver in childhood resembling hydatid cyst of the liver. Br J Radiol 1997; 70: 314–316.

    PubMed  CAS  Google Scholar 

  64. Kelekis NL, Semelka RC, Siegelman ES, Ascher SM, Outwater EK, Woosley JT, Reinhold C, Mitchell DG. Focal hepatic lymphoma: magnetic resonance demonstration using current techniques including gadolinium enhancement. Magn Reson Imaging 1997; 15: 625–636.

    PubMed  CAS  Google Scholar 

  65. Kew MC. Hepatic tumors and cysts. In Feldman M, Scharschmidt B.F., Sleisenger M.H. (eds): Sleisenger and Fordtran’s Gastrointestinal and Liver Disease ( 6th ed ). Philadelphia: WB Saunders, 1998, pp 1364–1387.

    Google Scholar 

  66. Kim AY, Choi BI, Kim TK, et al.: Hepatocellular carcinoma: power Doppler US with a contrast agent-preliminary results. Radiology 1998; 209: 135–140.

    PubMed  CAS  Google Scholar 

  67. Kim T, Murakami T, Takahashi S, Tsuda K, Tomoda K, Narumi Y, Oi H, Sakon M, Nakamura H. Optimal phases of dynamic CT for detecting hepatocellular carcinoma: evaluation of unenhanced and triple-phase images. Abdom Imaging 1999; 24: 473–480.

    PubMed  CAS  Google Scholar 

  68. Kirks DR, Griscom NT. Hepatobiliary tumors. In Practical Pediatric Imaging. Diagnostic Radiology of Infants and Children. Lippincott-Raven 1998: 954–969.

    Google Scholar 

  69. Klatskin G. Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis. Am J Med 1965; 38: 241–256.

    PubMed  CAS  Google Scholar 

  70. Kojiro M. Hepatocellular nodular lesions. In Kojiro M (ed) Pathology of early hepatocellular carcinoma and related lesions. Tokyo: Medical Publishers, 1996; 148–165.

    Google Scholar 

  71. Kojiro M, Nakashima T. Pathology of hepatocellular carcinoma. In: Okuda K, Ishak K.G., cds. Neoplasms of the Liver. New York: Springer-Verlag, 1987, pp 81–104.

    Google Scholar 

  72. Krinsky GA, Lee VS, Theise ND, Weinreb JC, Rofsky NM, Diflo T, Teperman LW. Hepatocellular carcinoma and dysplastic nodules in patients with cirrhosis: prospective diagnosis with MR imaging and explanation correlation. Radiology 2001; 219: 445–454.

    PubMed  CAS  Google Scholar 

  73. Kuszyk BS, Bluemke DA, Urban BA, Choti MA, Hruban RH, Sitzmann JV, Fishman EK. Portalphase contrast enhanced helical CT for the detection of malignant hepatic tumors: sensitivity based on comparison with intraoperative and pathologic findings. AJR 1996; 166: 91–95.

    PubMed  CAS  Google Scholar 

  74. LaBrecque DR. Neoplasia of the liver. In Kaplowitz N (ed): Liver and biliary disese ( 2nd ed ). Baltimore: Williams and Wilkins, 1996, pp 391–438.

    Google Scholar 

  75. Lack EE, Perez-Atayde AR, Schuster SR. Botryoid rhabdomyosarcoma of the biliary tract: report of five cases with ultrastructural observations and literature review. Am J Surg Pathol 1981: 5: 643–652.

    PubMed  CAS  Google Scholar 

  76. Lai CL, Gregory PB, Wu PC, Lok AS, Wong KP, Ng MM. Hepatocellular carcinoma in Chinese males and females: Possible causes for male predominance. Cancer 1987; 60: 1107–1110.

    PubMed  CAS  Google Scholar 

  77. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics. Cancer 1999; 49: 8–31.

    CAS  Google Scholar 

  78. Lauffer JM, Zimmermann A, Krahenbuhl L, Triller J, Baer HU. Epithelioid hemangioendothelioma of the liver. Cancer 1996: 78 (11): 2318–2327.

    PubMed  CAS  Google Scholar 

  79. Lee JH, Yang HM, Bak UB, Rim HJ. Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis. Korean J Parasitol 1994; 32: 13–18.

    PubMed  CAS  Google Scholar 

  80. Lencioni R, Pinto F, Armillotta N, Bartolozzi C. Assessment of tumor vascularity in hepatocellular carcinoma: comparison of power Doppler US and color Doppler US. Radiology 1996; 201: 353–358.

    PubMed  CAS  Google Scholar 

  81. Levin B. Gallbladder carcinoma. Ann Oncol 1999; 10129–130.

    Google Scholar 

  82. Lewis KH, Chezmar JL. Hepatic metastases. Magn Reson Imaging Clin North Am 1997; 5: 319–330.

    CAS  Google Scholar 

  83. Lim JH, Cho JM, Kim EY, Park CK. Dysplastic nodules in liver cirrhosis: evaluation of hemodynamics with CT during arterial portography and CT hepatic arteriography. Radiology 2000; 214: 869–874.

    PubMed  CAS  Google Scholar 

  84. Lim JH, Choi D, Cho SK, Kim SH, Lee WJ, Lim HK, Park CK, Paik SW, Kim YI. Conspicuity if hepatocellular nodular lesions in cirrhotic livers at ferumoxides-enhanced MR imaging: importance of Kupffer cell number. Radiology 2001; 220: 669–676.

    PubMed  CAS  Google Scholar 

  85. Linstedt-Hilden M, Brambs HJ. Two different manifestations of botryoid sarcoma (embryonal rhabdomyosarcoma) of the biliary tree. Bildgebung 1994; 61: 40–43.

    PubMed  CAS  Google Scholar 

  86. Locker GY. Doroshow JH, Zwelling LA, Chabner BA. The clinical features of hepatic angiosarcoma: a report of four cases and a review of the English literature. Medicine (Baltimore) 1979; 58: 48–64.

    CAS  Google Scholar 

  87. Manfredi R, Maresca G, Baron RL, Cotroneo AR, De Gaetano AM, De Franco A, Pirovano G, Spinazzi A, Marano P. Manfredi R., Maresca G., Baron R.L., et al.: Delayed MR imaging of hepatocellular carcinoma enhanced by gadobenate dimeglumine (Gd-BOPTA). J Magn Reson Imaging 1999; 9: 704–710.

    PubMed  CAS  Google Scholar 

  88. Marcos-Alvarez A, Jenkins RL. Cholangiocarcinoma. Surg Oncol Clin North Am 1996; 5: 301–316.

    CAS  Google Scholar 

  89. McLarney JK, Rucker PT, Bender GN, Goodman ZD, Kashitani N, Ros PR. Fibrolamellar carcinoma of the liver: radiologie-pathologic correlation. Radiographies 1999; 19: 453–471.

    CAS  Google Scholar 

  90. Mihara S, Matsumoto H, Tokunaga F, Yano H, Ota M, Yamashita S. Botryoid rhabdomyosarcoma of the gallbladder in a child. Cancer 1982; 49: 812–818.

    PubMed  CAS  Google Scholar 

  91. Miller JH, Greenspan BS. Integrated imaging of hepatic tumors in childhood. Part. I: Malignant lesions (primary and metastatic). Radiology 1985; 154: 83–90.

    PubMed  CAS  Google Scholar 

  92. Miller WJ, Dodd GD 3rd, Federle MP, Baron RL. Epithelioid hemangioendothelioma of the liver: findings with pathologic correlation. AJR 1992: 159: 53–57.

    PubMed  CAS  Google Scholar 

  93. Moon WK, Kim WS, Kim IO, Yeon KM, Yu IK, Choi BI, Han MC. Undifferentiated embryonal sarcoma of the liver: US and CT findings. Pediatr Radiol 1994; 24: 500–503.

    PubMed  CAS  Google Scholar 

  94. Murakami T, Baron RL, Peterson MS, Oliver JH 3rd, Davis PL, Confer SR, Federle MP. Hepatocellular carcinoma: MR imaging with mangoafodipir trisodium (Mn-DPDP). Radiology 1996; 200: 69–77.

    PubMed  CAS  Google Scholar 

  95. Murakami T, Kim T, Nakamura H. Hepatitis, cirrhosis, and hepatoma. J.Magn Reson Imaging 1998; 8: 346–358.

    PubMed  CAS  Google Scholar 

  96. Murakami T, Kim T, Takamura M, Hori M, Takahashi S, Federle MP, Tsuda K, Osuga K, Kawata S, Nakamura H, Kudo M. Hypervascular hepatocellular carcinoma: detection with double arterial phase multidetector row helical CT. Radiology 2001; 218: 763–767.

    PubMed  CAS  Google Scholar 

  97. Nakashima T, Kojiro M. Hepatocellular carcinoma: An Atlas of Its Pathology. Tokyo: Springer-Verlag, 1987.

    Google Scholar 

  98. Nerlich AG, Majewski S, Hunzelmann N, Brenner RE, Wiebecke B, Muller PK, Kreig T, Remberger K… Excessive collagen formation in fibrolamellar carcinoma of the liver: a morphological and biochemical study. Mod Pathol. 1992; 5: 580–585.

    PubMed  CAS  Google Scholar 

  99. Newton WA Jr, Gehan EA, Webber BL, Marsden HB, van Unnik AJ, Hamoudi AB, Tsokos MG, Shimada H, Harms D, Schmidt D, et al. Classification of rhabdomyosarcoma and related sarcomas. Cancer 1995; 76: 1073–1085.

    PubMed  Google Scholar 

  100. Noguchi S, Yamamoto R, Tatsuta M, Kasugai H, Okuda S, Wada A, Tamura H. Cell features and patterns in fine-needle aspirates of hepatocellular carcinoma. Cancer 1986; 58: 321–328.

    PubMed  CAS  Google Scholar 

  101. Nzeako UC, Goodman ZD, Ishak KG. Hepatocellular carcinoma in cirrhotic and noncirrhotic livers: a clinico-histopathologic study of 804 North American patients. Am J Clin Pathol 1996; 105: 65–75.

    PubMed  CAS  Google Scholar 

  102. Ohsawa M, Aozasa K, Horiuchi K, Kataoka M, Hida J, Shimada H, Oka K, Wakata Y. Malignant lymphoma of the liver. Dig Dis Sci 1992; 37: 1105–1109.

    PubMed  CAS  Google Scholar 

  103. Oliver JH 3rd, Baron RL, Federle MP, Rockette HE Jr. Detecting hepatocellular carcinoma: value of unenhanced or arterial phase CT imaging or both used in conjunction with conventional portal venous phase contrast-enhanced CT imaging. AJR 1996; 167: 71–77.

    PubMed  Google Scholar 

  104. Orsatti G, Hytiroglou P, Thung SN, Ishak KG, Paronetto F. Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: a role for transforming growth factor beta. Liver 1997; 12: 152–156.

    Google Scholar 

  105. Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics. CA Cancer J Clin 1997; 47: 5–13.

    PubMed  CAS  Google Scholar 

  106. Patil KK, Omojola MF, Khurana P, Iyengar JK. Embryonal rhabdomyosarcoma within a choledochal cyst. Can Assoc Radiol J 1992; 43: 145–148.

    PubMed  CAS  Google Scholar 

  107. Paulson E.K. Evaluation of the liver for metastatic disease. Semin in Liver Disease 2001; 21 (2): 225–235.

    CAS  Google Scholar 

  108. Peterson MS, Murakami T, Baron RL. MR imaging patterns of gadolinium retention within liver neoplasms. Abdom Imaging 1998; 23: 592–599.

    PubMed  CAS  Google Scholar 

  109. Peterson MS, Baron RL, Rankin SC. Hepatic angiosarcoma: findings on multiphasic contrast-enhanced helical CT do not mimic hepatic hemangioma. Am J Roentgenol 2000; 175: 165–170.

    CAS  Google Scholar 

  110. Peterson MS, Baron RL, Marsh JW Jr, Oliver JH 3rd, Confer SR, Hunt LE. Pretransplantation surveillance for possible hepatocellular carcinoma in patients with cirrhosis: epidemiology and CT-based tumor detection rate in 430 cases with surgical pathologic correlation. Radiology; 2000; 217: 743–749.

    PubMed  CAS  Google Scholar 

  111. Pobiel RS, Bisset III GS. Pictorial essay: imaging of liver tumors in the infant and child. Pediatr Radiol 1995; 25: 495–506.

    PubMed  CAS  Google Scholar 

  112. Polk HC. Carcinoma and the calcified gallbladder. Gastroenterology 1966; 50: 582–585.

    PubMed  Google Scholar 

  113. Roebuck DJ, Yang WT, Lam WW. Stanley P. Hepatobiliary rhabdomyosarcoma in children: diagnostic radiology. Pediatr Radiol 1998; 28: 101–108.

    PubMed  CAS  Google Scholar 

  114. Rofsky NM, Earls JP. Mangafodipir trisodium injection (Mn-DPDP). A contrast agent for abdominal MR imaging. Magn Reson Imaging Clin N Am 1996; 4: 73–85

    PubMed  CAS  Google Scholar 

  115. Ros PR, Taylor HM. Malignant Tumors of the liver. Textbook of gastrointenstinal radiology, Vol II, second edition. Copyright 2000: 1523–1568.

    Google Scholar 

  116. Ros PR, Olmsted WW, Dachman AH, Goodman ZD, Ishak KG, Hartman DS. Undifferentiated (embryonal) sarcoma of the liver: radiologie pathologic correlation. Radiology 1986; 160: 141–145.

    Google Scholar 

  117. Ros PR, Murphy BJ, Buck JL, Olmedilla G, Goodman Z. Encapsulated hepatocellular carcinoma: radiologie findings and pathologic correlation. Gastrointest Radio] 1990; 15: 233–237.

    CAS  Google Scholar 

  118. Runge VM, Lee C, Williams NM. Detectability of small liver metastases with gadolinium BOPTA. Invest Radio) 1997; 32: 557–565.

    CAS  Google Scholar 

  119. Ruymann FB, Raney RB Jr, Crist WM, Lawrence W Jr, Lindberg RD, Soule EH. for the Intergroup Rhabdomyosarcoma Study of CCSG and POG. Rabdomyosarcoma of the biliary tree in childhood: a report from the Intergroup Rhabdomyosarcoma Study. Cancer 1985; 56: 575–581.

    Google Scholar 

  120. Ryan J. Straus DJ, Lange C. Primary lymphoma of the liver. Cancer 1988; 61: 370–375.

    PubMed  Google Scholar 

  121. Sagoh T, Itoh K, Togashi K, Shibata T, Minami S, Noma S, Yamashita K, Nishimura K, Asato R, Mori K, et al.. Gallbladder carcinoma: evaluation with MR imaging. Radiology 1990; 174: 131–136.

    PubMed  CAS  Google Scholar 

  122. Sakamoto M, Hirohashi S, Shimosato Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and early hepatocellular carcinoma. Huni Pathol 1991; 22: 172–178.

    CAS  Google Scholar 

  123. Sanders LM, Botet JF, Straus DJ, Ryan J, Filippa DA, Newhouse JH. CT of primary lymphoma of the liver. AJR 1989; 152: 973–976.

    PubMed  CAS  Google Scholar 

  124. Schweizer P, Schweizer M, Wehrmann M. Major resection for embryonal rhabdomyosarcoma of the biliary tree. Pediatr Surg Int 1994; 9: 268–273.

    Google Scholar 

  125. Seneterre E, Taourel P, Bouvier Y. Pradel J. Van Beers B, Daures JP, Pringot J, Mathieu D, Bruel JM. Detection of hepatic metastases: Ferumoxides-enhanced MR Imaging versus unenhanced MR Imaging and CT during arterial portography. Radiology 1996; 200: 785–792.

    PubMed  CAS  Google Scholar 

  126. Sherlock S, Dooley J. Diseases of the liver and biliary system (9’ ed). Oxford: Blackwell Scientific, 1993, pp 44–61.

    Google Scholar 

  127. Shirkhoda A, Ros PR, Farah J, Staab EV. Lymphoma of the solid abdominal viscera. Radiol Clin North Am 1990; 28: 785–799.

    PubMed  CAS  Google Scholar 

  128. Siegel MJ. Pediatric liver imaging. Seminars in liver disease 2001; 21: 251–269.

    PubMed  CAS  Google Scholar 

  129. SIOPEL III. International society of pediatric oncology: Liver tumours studies. Hepatoblastoma and Hepatocellular Carcinoma. 1998.

    Google Scholar 

  130. Smalley SR, Moertel CG, Hilton JF, Weiland LH, Weiand HS, Adson MA, Melton LJ 3rd, Batts K. Hepatoma in the noncirrhotic liver. Cancer 1988; 62: 1414–1424.

    PubMed  CAS  Google Scholar 

  131. Sons HU, Borchard F, Joel BS. Carcinoma of the gallbladder: autopsy findings in 287 cases and review of the literature. J Surg Oncol 1985; 28: 199–206.

    PubMed  CAS  Google Scholar 

  132. Soyer P, Roche A. Levesque M, Legmann P. CT of fibrolamellar hepatocellular carcinoma. J Computed Assist Tomogr. 1991; 14: 533–538.

    Google Scholar 

  133. Soyer P, Gouhiri M, Boudiaf M, Brocheriou-Spelle I, Kardache M, Fishman EK, Rymer R. Carcinoma of the gallbladder: imaging features with surgical correlation. AJR 1997; 169: 781–784.

    PubMed  CAS  Google Scholar 

  134. Stevens WR, Johnson CD, Stephens DH, Nagorney DM. Fibrolamellar hepatocellular carcinoma: stage at presentation and results of aggressive surgical management. AJR 1995; 164: 1153–1158.

    PubMed  CAS  Google Scholar 

  135. Stocker JT, Ishak KG. Undifferentiated (embryonal) sarcoma of the liver. Report of 31 cases. Cancer 1978; 42:336–348.

    Google Scholar 

  136. Sussman EB, Nydick J, Gray GF. Hemangioendothelial sarcoma of the liver and hemochromatosis. Arch Pathol Lab Med 1974; 97: 39–42.

    CAS  Google Scholar 

  137. Takano H, Smith WL. Gastrointestinal tumors of childhood. Radiol Clin North Am. 1997; 35: 1374.

    Google Scholar 

  138. Tamburro CH. Relationship of vinyl monomers and liver cancers: angiosarcoma and hepatocellular carcinoma. Semin Liver Dis 1984; 4: 158–169.

    PubMed  CAS  Google Scholar 

  139. Thorsen MK, Quiroz F, Lawson TL, Smith DF, Foley WD, Stewart ET. Primary biliary carcinoma: CT evaluation. Radiology 1984; 152: 479–483.

    PubMed  CAS  Google Scholar 

  140. Tsuchida Y, Ikeda H, Suzuki N, Takahashi A, Kuroiwa M, Sakai M, Shimizu H, Shitara T, Yamanouchi H. Hirato J.. A case of well-differentiated, fetal-type hepatoblastoma with very low serum alpha-fetoprotein. J Ped Surg 1999; 34: 1762–1764.

    CAS  Google Scholar 

  141. Van Beers B, Roche A, Mathieu D, Menu Y, Delos M, Otte JB, Lalonde L, Pringot J. Epithelioid hemangioendothelioma of the liver: MR and CT findings. J Comput Assist Tomogr 1992; 16: 420–424.

    PubMed  Google Scholar 

  142. Walker NI, Horn MJ, Strong RW, et al. Undifferentiated (embryonal) sarcoma of the liver. Pathologic findings and long-term survival after complete surgical resection. 1992; 69: 52–59.

    CAS  Google Scholar 

  143. Wang C, Ahlstrom H, Ekholm S, Fagertun H, Hellstrom M, Hemmingsson A, Holtas S, Isberg B, Jonnson E, Lonnemark-Magnusson M, McGill S, Wallengren NO, Westuran L..: Diagnostic efficacy of MnDPDP in MR imaging of the liver. A phase III multicentre study. Acta Radiol 1997; 38: 643–649.

    PubMed  CAS  Google Scholar 

  144. Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer 1982; 50: 970–981.

    PubMed  CAS  Google Scholar 

  145. Wernecke K, Peters PE, Kruger KG. Ultrasonographic patterns of focal hepatic and splenic lesions in Hodgkin’s and non-Hodgkin lymphoma. The British Journal of Radiology 1987; 60: 655–660.

    PubMed  CAS  Google Scholar 

  146. Wilbur AC, Sagireddy PB, Aizenstein RI. Carcinoma of the gallbladder: color Doppler ultrasound and CT findings. Abdom Imaging 1997: 22: 187–190.

    PubMed  CAS  Google Scholar 

  147. Winston CB, Schwartz LH, Fong Y, Blumgart LH, Panicek DM. Hepatocellular carcinoma: MR imaging findings in cirrhotic livers and noncirrhotic livers. Radiology 1999; 210: 75–79.

    PubMed  CAS  Google Scholar 

  148. Worawattanakul S, Semelka RC, Kelekis NL, Woosley JT. Angiosarcoma of the liver: MR imaging pre-and post chemotherapy. Magn Reson Imaging 1997; 15: 613–617.

    PubMed  CAS  Google Scholar 

  149. Worawattanakul S, Semelka RC, Noone TC, Calvo BF, Kelekis NL, Woosley JT. Cholangiocarcinoma: specrum of appearances on MR images using current techniques. Magn Reson Imaging 1998; 16: 993 1003.

    Google Scholar 

  150. Yamanaka N, Okamoto E, Ando T, Oriyama T, Fujimoto J, Furukawa K, Tanaka T, Tanaka W, Nishigami T. Clinicopathologic spectrum of resected extraductal mass-forming intrahepatic cholangiocarcinoma. Cancer 1995; 76: 2449–2456.

    PubMed  CAS  Google Scholar 

  151. Yamashita Y, Fan ZM, Yamamoto H, Matsukawa T, Yoshimatsu S, Miyazaki T, Sumi M, Harada M, Takahashi M..: Spin-echo and dynamic gadolinium-enhanced FLASH MR imaging of hepatocellular carcinoma: correlation with histopathologic findings. J Magn Reson 1994; 4: 83–90.

    CAS  Google Scholar 

  152. Yeo CJ, Pitt HA, Cameron JL. Cholangiocarcinoma. Surg Clin North Am 1990; 70: 1429–1447.

    PubMed  CAS  Google Scholar 

  153. Yoon W, Kim JK, Kang HK. Hepatic undifferentiated embryonal sarcoma: MR findings. J Computed Assist Tomogr 1997; 21: 100–102.

    CAS  Google Scholar 

  154. Yoshida Y, Imai Y, Murakami T, Nishikawa M, Kurokawa M, Yonezawa T, Tokunaga K, Fukushima Y, Wakasa K, Kim T, Nakamura H, Sakon M, Monden M. lntrahepatic cholangiocarcinoma with marked hypervascularity. Abdom Imaging 1999; 24: 66–68.

    PubMed  CAS  Google Scholar 

  155. Yu JS, Kim KW, Kim EK, Lee JT, Yoo HS. Contrast enhancement of small hepatocellular carcinomas: usefulness of three successive early image acquisitions during multiphase dynamic MR imaging. AJR 1999; 173: 597–604.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Diagnostic Radiology, University Hospital of Saarland, 66421, Homburg/Saar, Germany

    Günther Schneider M.D.

  2. Department of Radiology, University of Brescia, Piazale Spedali Civili 1, 25023, Brescia, Italy

    Luigi Grazioli M.D.

  3. The Division of Abdominal Imaging and Intervention, Department of Radiology and Harvard Medical School, 02114, Boston, MA, USA

    Sanjay Saini M.D.

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Editors and Affiliations

  1. Department of Diagnostic Radiology, University Hospital of Saarland, 66421, Homburg/Saar, Germany

    Günther Schneider M.D.

  2. Department of Radiology, University of Brescia, Piazale Spedali Civili 1, 25023, Brescia, Italy

    Luigi Grazioli M.D.

  3. The Division of Abdominal Imaging and Intervention, Department of Radiology and Harvard Medical School, 02114, Boston, MA, USA

    Sanjay Saini M.D.

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Schneider, G., Grazioli, L., Saini, S. (2003). Imaging of Malignant Focal Liver Lesions. In: Schneider, G., Grazioli, L., Saini, S. (eds) MRI of the Liver. Springer, Milano. https://doi.org/10.1007/978-88-470-2946-0_5

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