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Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Non-Small-Cell Lung Cancer

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Atlas of Lymphoscintigraphy and Sentinel Node Mapping

Abstract

Non-small-cell lung cancer (NSCLC) is the most common malignancy worldwide and a major cause of cancer-related death [1]. It represents 85% of all lung cancers and usually grows and spreads more slowly than small-cell lung cancer. Despite advances in surgery, chemotherapy, and radiation therapy over the last decades, the death rate from NSCLC has remained largely unchanged. Such poor long-term survival probably results from the fact that early-stage disease is asymptomatic and the onset of symptoms marks the presence of advanced, incurable disease.

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References

  1. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics, 2012. CA Cancer J Clin 62:10–29.

    Article  PubMed  Google Scholar 

  2. Keller SM, Adak S, Wagner H, Johnson DH (2000) Mediastinal lymph node dissection improves survival in patients with stages II and IIIa non-small cell lung cancer. Eastern Cooperative Oncology Group. Ann Thorac Surg 70:358–365.

    Article  PubMed  CAS  Google Scholar 

  3. Naruke T, Goya T, Tsuchiya R, Suemasu K (1988) The importance of surgery to non-small cell carcinoma of lung with mediastinal lymph node metastasis. Ann Thorac Surg 46:603–610.

    Article  PubMed  CAS  Google Scholar 

  4. Shen J, Wallace AM, Bouvet M (2002) The role of sentinel lymph node biopsy for melanoma. Semin Oncol 29:341–352.

    Article  PubMed  Google Scholar 

  5. Petrek JA, Senie RT, Peters M, Rosen PP (2001) Lymphedema in a cohort of breast carcinoma survivors 20. years after diagnosis. Cancer 92:1368–1377.

    Article  PubMed  CAS  Google Scholar 

  6. Nomori H, Horio H, Naruke T et al (2002) Use of technetium-99m tin colloid for sentinel lymph node identification in non-small cell lung cancer. J Thorac Cardiovasc Surg 124:486–492.

    Article  PubMed  Google Scholar 

  7. Liptay MJ, Grondin SC, Fry WA et al (2002) Intraoperative sentinel lymph node mapping in non-small-cell lung cancer improves detection of micrometastases. J Clin Oncol 20:1984–1988.

    Article  PubMed  Google Scholar 

  8. Mountain CF, Dresler CM (1997) Regional lymph node classification for lung cancer staging. Chest 111:1718–1723.

    Article  PubMed  CAS  Google Scholar 

  9. Kubuschock B, Passlick B, Izbicki JR et al (1999) Disseminated tumor cells in lymph nodes as a determinant for survival in surgically resected non-small cell lung cancer. J Clin Oncol 17:19–24.

    Google Scholar 

  10. Riquet M, Manac’h D, Pimpec-Barthes F et al (1999) Prognostic significance of surgical-pathologic N1. disease in non-small cell carcinoma of the lung. Ann Thorac Surg 67:1572–1576.

    Article  PubMed  CAS  Google Scholar 

  11. Passlick B, Kubuschock B, Sienel W et al (2002) Mediastinal lymphadenectomy in non-small cell lung cancer: effectiveness in patients with or without nodal micrometastases — results of a preliminary study. Eur J Cardiothorac Surg 21:520–526.

    Article  PubMed  CAS  Google Scholar 

  12. Naruke T, Tsuchiya R, Kondo H et al (1999) Lymph node sampling in lung cancer: how should it be done? Euro Eur J Cardiothorac Surg 16:17–24.

    Article  Google Scholar 

  13. Izbicki JR, Thetter O, Habekost M et al (1994) Radical systematic mediastinal lymphadenectomy in non-small cell lung cancer: a randomized controlled trial. Br J Surg 81:229–235.

    Article  PubMed  CAS  Google Scholar 

  14. Allen MS, Darling G, Pechet T et al (2006) Morbidity and mortality of major pulmonary resection in patients with early stage lung cancer initial results of the randomized, prospective ACOSOG Z0030 Trial. Ann Thorac Surg 81:1013–1019.

    Article  PubMed  Google Scholar 

  15. Li SH, Wang Z, Liu XY, Liu FY (2008) Gene diagnosis and prognostic significance of lymph node micrometastasis after complete resection of histologically node-negative non-small cell lung cancer. World J Surg 32:1651–1656.

    Article  PubMed  Google Scholar 

  16. Tezel C, Ersev AA, Kiral H et al (2006) The impact of immunohistochemical detection of positive lymph nodes in early stage lung cancer. Thorac Cardiovasc Surg 54:124–128.

    Article  PubMed  CAS  Google Scholar 

  17. Nosotti M, Falleni M, Palleschi A et al (2005) Quantitative realtime polymerase chain reaction detection of lymph node lung cancer micrometastasis using carcinoembryonic antigen marker. Chest 128:1539–1544.

    Article  PubMed  Google Scholar 

  18. Little AG, DeHoyos A, Kirgan DM et al (1999) Intraoperative lymphatic mapping for non-small cell lung cancer: the sentinel node technique. J Thorac Cardiovasc Surg 117:220–234.

    Article  PubMed  CAS  Google Scholar 

  19. Sugi K, Fukuda M, Nakamura H, Kaneda Y (2003) Comparison of three tracers for detecting sentinel lymph nodes in patients with clinical N0. lung cancer. Lung Cancer 39:37–40.

    Article  PubMed  Google Scholar 

  20. Nakagawa T, Minamiya Y, Katayose Y et al (2003) A novel method for sentinel lymph node mapping using magnetite in patients with non-small cell lung cancer. J Thorac Cardiovasc Surg 126:563–567.

    Article  PubMed  Google Scholar 

  21. Sugi K, Kobayashi S, Yagi R, Matsuoka T (2008) Sentinel node mapping and micrometastasis in patients with clinical stage IA non-small cell lung cancer. Interact Cardiovasc Thorac Surg 7:913–915.

    Article  PubMed  Google Scholar 

  22. Minamiya Y, Ito M, Hosono Y et al (2007) Subpleural injection of tracer improves detection of mediastinal sentinel lymph nodes in non-small cell lung cancer. Eur J Cardiothorac Surg 32:770–775.

    Article  PubMed  Google Scholar 

  23. Khullar O, Frangioni JV, Colson Y (2009) Image-guided sentinel lymph node mapping and nanotechnology-based nodal treatment in lung cancer using invisible near-infrared fluorescent light. Semin Thorac Cardiovasc Surg 21:309–315.

    Article  PubMed  Google Scholar 

  24. Schmidt FE, Woltering EA, Webb WR et al (2002) Sentinel nodal assessment in patients with carcinoma of the lung. Ann Thorac Surg 74:870–874.

    Article  PubMed  Google Scholar 

  25. Melfi FM, Chella A, Menconi GF et al (2003) Intraoperative radio-guided sentinel lymph node biopsy in non-small cell lung cancer. Eur J Cardiothorac Surg 23:214–220.

    Article  PubMed  Google Scholar 

  26. Lardinois D, Brack T, Gaspert A et al (2003) Bronchoscopic radio-isotope injection for sentinel lymph-node mapping in potentially resectable non-small-cell lung cancer. Eur J Cardiothorac Surg 23:824–827.

    Article  PubMed  CAS  Google Scholar 

  27. Sugi K, Kaneda Y, Sudoh M et al (2003) Effect of radioisotope sentinel node mapping in patients with cT1. N0. M0. lung cancer. J Thorac Cardiovasc Surg 126:568–573.

    Article  PubMed  Google Scholar 

  28. Sugi K, Kitada K, Murakami T et al (2004) Sentinel node biopsy for staging of small peripheral lung cancer. Kyobu Geka 57:14–17.

    PubMed  CAS  Google Scholar 

  29. Liptay MJ (2004) Sentinel node mapping in lung cancer. Ann Surg Oncol 11:271S–274S

    PubMed  Google Scholar 

  30. Ueda K, Suga K, Kaneda Y et al (2004) Radioisotope lymph node mapping in nonsmall cell lung cancer: can it be applicable for sentinel node biopsy? Ann Thorac Surg 77:426–430.

    Article  PubMed  Google Scholar 

  31. Nomori H, Watanabe K, Ohtsuka T et al (2004) In vivo identification of sentinel lymph nodes for clinical stage I non-small cell lung cancer for abbreviation of mediastinal lymph node dissection. Lung Cancer 46:49–55.

    Article  PubMed  Google Scholar 

  32. Tiffet O, Nicholson AG, Khaddage A et al (2005) Feasibility of the detection of the sentinel lymph node in peripheral non-small cell lung cancer with radioisotopic and blue dye techniques. Chest 127:443–448.

    Article  PubMed  Google Scholar 

  33. Atinkaya C, Ozlem Küçük N, Koparal H et al (2005) Mediastinal intraoperative radioisotope sentinel lymph node mapping in non-small-cell lung cancer. Nucl Med Commun 26:717–720.

    Article  PubMed  Google Scholar 

  34. Rzyman W, Hagen OM, Dziadziuszko R et al (2006) Intraoperative, radio-guided sentinel lymph node mapping in 110. nonsmall cell lung cancer patients. Ann Thorac Surg 82:237–242.

    Article  PubMed  Google Scholar 

  35. Nomori H, Ikeda K, Mori T et al (2007) Sentinel node navigation segmentectomy for clinical stage IA non-small cell lung cancer. J Thorac Cardiovasc Surg 133:780–785.

    Article  PubMed  Google Scholar 

  36. Nomori H, Ikeda K, Mori T et al (2007) Sentinel node identification in clinical stage Ia non-small cell lung cancer by a combined single photon emission computed tomography/computed tomography system. J Thorac Cardiovasc Surg 134:182–187.

    Article  PubMed  Google Scholar 

  37. Meyer A, Cheng C, Antonescu C et al (2007) Successful migration of three tracers without identification of sentinel nodes during intraoperative lymphatic mapping for non-small cell lung cancer. Interact Cardiovasc Thorac Surg 6:214–218.

    Article  PubMed  Google Scholar 

  38. Di Lieto E, Gallo G, Scarpati VD et al (2007) Lymph node sentinel detection in lung resection for non small cell lung cancer: our experience. Recenti Prog Med 98:327–328.

    PubMed  Google Scholar 

  39. Melfi FM, Lucchi M, Davini F et al (2008) Intraoperative sentinel lymph node mapping in stage I non-small cell lung cancer: detection of micrometastases by polymerase chain reaction. Eur J Cardiothorac Surg 34:181–186.

    Article  PubMed  Google Scholar 

  40. Sugi K, Kobayashi S, Yagi R, Matsuoka T (2008) Usefulness of sentinel lymph node biopsy for the detection of lymph node micrometastasis in early lung cancer. Interact Cardiovasc Thorac Surg 7:913–915.

    Article  PubMed  Google Scholar 

  41. Liptay MJ, D’amico TA, Nwogu C et al (2009) Intraoperative sentinel node mapping with technetium-99m in lung cancer: results of CALGB 140203. Multicenter Phase II Trial. J Thorac Oncol 4:198–202.

    Article  PubMed  Google Scholar 

  42. Soltesz EG, Kim S, Laurence RG et al (2005) Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. Ann Thorac Surg 79:269–277

    Article  PubMed  Google Scholar 

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Correspondence to Giuseppe Boni .

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Boni, G., Melfi, F.M.A., Manca, G., Davini, F., Mariani, G. (2013). Preoperative and Intraoperative Lymphatic Mapping for Radioguided Sentinel Node Biopsy in Non-Small-Cell Lung Cancer. In: Mariani, G., Manca, G., Orsini, F., Vidal-Sicart, S., Valdés Olmos, R.A. (eds) Atlas of Lymphoscintigraphy and Sentinel Node Mapping. Springer, Milano. https://doi.org/10.1007/978-88-470-2766-4_12

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  • DOI: https://doi.org/10.1007/978-88-470-2766-4_12

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2765-7

  • Online ISBN: 978-88-470-2766-4

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