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Aspetti psicologici nella sclerosi multipla pp 11–26Cite as

Evoluzione della malattia

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Riassunto

La sclerosi multipla (SM) presenta manifestazioni cliniche estremamente variabili sia nelle caratteristiche di esordio sia nell’evoluzione della malattia (decorso, frequenza di ricadute, velocità di progressione). Negli ultimi due decenni si è assistito a un grande sforzo e impulso per la ricerca di trattamenti in grado di modificare la storia naturale della SM, specie per quel che riguarda la frequenza delle ricadute cliniche e la loro severità. Una grande attenzione è stata inoltre posta verso il trattamento sintomatico la cui finalità è indirizzata a migliorare il livello di efficienza psicofisica, la qualità della vita, la riduzione della disabilità e dell’handicap e di consentire a ogni persona affetta un adeguato rapporto con il proprio corpo e l’ambiente. In sintesi, l’idea guida dell’intervento terapeutico sintomatico deve essere rappresentata prevalentemente dal grado di limitazione funzionale e dall’influenza sulla qualità di vita del paziente.

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Letture consigliate

  • Amato MP, Portaccio E, Goretti B et al (2010) Cognitive impairment in early stages of multiple sclerosis. Neurol Sci 31(suppl 2):S211–214

    Article  PubMed  Google Scholar 

  • Ben-Zacharia A, Lublin F (2001) Palliative care in patients with multiple sclerosis. Neurol Clin 19:801–828

    Article  PubMed  Google Scholar 

  • Ben-Zacharia AB (2011) Therapeutics for multiple sclerosis symptoms. Mt Sinai J Med 78: 176–191

    Article  PubMed  Google Scholar 

  • Bergamaschi R, Romani A, Versino M et al (1997) Clinical aspects of fatigue in multiple sclerosis. Funct Neurol 12:247–251

    PubMed  Google Scholar 

  • Bittar RG, Hyam J, Nandi D et al (2005) Thalamotomy versus thalamic stimulation for multiple sclerosis tremor. J Clin Neurosci 12:638–642

    Article  PubMed  Google Scholar 

  • Confavreux C, Vukusic S, Moreau T et al (2000) Relapses and progression of disability in multiple sclerosis. N Engl J Med 16(343):1430–1438

    Article  Google Scholar 

  • Feinstein A (2002) An examination of suicidal intent in patients with multiple sclerosis. Neurology 59(5):674–678

    Article  PubMed  Google Scholar 

  • Filippi M, Rocca MA (2010) MRI and cognition in multiple sclerosis. Neurol Sci 31(suppl 2): S231–234

    Article  PubMed  Google Scholar 

  • Fisniku LK, Brex PA, Altmann DR et al (2008) Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis. Brain 131:808–817

    Article  PubMed  Google Scholar 

  • Fowler CJ, Miller JR, Sharief MK et al (2005) A double blind, randomised study of sildenafil citrate for erectile dysfunction in men with multiple sclerosis. J Neurol Neurosurg Psychiatry 76(5):700–705

    Article  PubMed  Google Scholar 

  • Ghezzi A, Martinelli V, Torri V et al (1999) Long term follow up of isolated optic neuritis: the risk of developing multiple sclerosis, its outcome, and the prognostic role of paraclinical test. J Neurol 246:770–775

    Article  PubMed  Google Scholar 

  • Goldman Consensus Group (2005) The Goldman consensus statement on depression in multiple sclerosis. Mult Scler 11(3):328–337

    Article  Google Scholar 

  • Hawkins SA, McDonnell GV (1999) Benign multiple sclerosis? Clinical course, long term follow-up and assessment of prognostic factors. J Neurol Neurosurg Psychiatry 67:148–152

    Article  PubMed  Google Scholar 

  • Honarmand K, Akbar N, Kou N et al (2011) Predicting employment status in multiple sclerosis patients: the utility of the MS functional composite. J Neurol 258(2):244–249

    Article  PubMed  Google Scholar 

  • Kalsi V, Gonzales G, Popat R et al (2007) Botulinum injections for the treatment of bladder symptoms of multiple sclerosis. Ann Neurol 62(5):452–457

    Article  PubMed  Google Scholar 

  • Krupp LB, Coyle PK, Doscher C et al (1995) Fatigue therapy in multiple sclerosis: results of a double-blind, randomized, parallel trial of amantadine, pemoline, and placebo. Neurology 45(11):1956–1961

    Article  PubMed  Google Scholar 

  • Kurtzke JF (1983) Rating neurological impairment in multiple sclerosis. An expanded disability status scale (EDSS). Neurology 33(11):1444–1452

    Article  PubMed  Google Scholar 

  • Lublin FD, Reingold SC (1996) Defining the clinical course of multiple sclerosis. Results of an international survey. Neurology 46(4):907–911

    Article  PubMed  Google Scholar 

  • Miller DH, Thompson AJ, Morrissey SP et al (1992) High dose steroids in acute relapses of multiple sclerosis: MRI evidence for a possible mechanism of therapeutic effect. J Neurosurg Psychiatry 55:450–453

    Article  Google Scholar 

  • Mowry EM (2011) Natural history of multiple sclerosis: early prognostic factors. Neurol Clin 29(2):279–292

    Article  PubMed  Google Scholar 

  • Notcutt W, Langford R, Davies P et al (2012) A placebo-controlled, parallel-group, randomised withdrawal study of subjects with symptoms of spasticity due to multiple sclerosis who are receiving long-term Sativex® (nabiximols). Mult Scler 18:219–228

    Article  PubMed  Google Scholar 

  • Novotna A, Mares J, Ratcliffe S et al (2011) A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis. Eur J Neurol 18(9):1122–1131

    Article  PubMed  Google Scholar 

  • Okuda DT, Mowry EM, Beheshtian A et al (2009) Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome. Neurology 72(9):800–805

    Article  PubMed  Google Scholar 

  • Paparrigopoulos T, Ferentinos P, Kouzoupis A et al (2010) The neuropsychiatry of multiple sclerosis: Focus on disorders of mood, affect and behaviour. Int Rev Psychiatry 22(1):14–21

    Article  PubMed  Google Scholar 

  • Patten SB, Beck CA, Williams JV et al (2003) Major depression in multiple sclerosis. A population-based perspective. Neurology 61(11):1524–1527

    Article  PubMed  Google Scholar 

  • Patti F, Amato MP, Trojano M et al (2011) Multiple sclerosis in Italy: cost-of-illness study. Neurol Sci 32(5):787–794

    Article  Google Scholar 

  • Rao S (2004) Cognitive function in patients with multiple sclerosis: impairment and treatment. Int J MS Care 6:9–22

    Article  Google Scholar 

  • Riise T, Mohr DC, Munger KL et al (2011) Stress and the risk of multiple sclerosis. Neurology 76(22):1866–1871

    Article  PubMed  Google Scholar 

  • Samkoff LM, Goodman AD (2011) Symptomatic management in multiple sclerosis. Neurol Clin 29(2):449–463

    Article  PubMed  Google Scholar 

  • Schwid SR, Thornton CA, Pandya S et al (1999) Quantitative assessment of motor fatigue and strength in MS. Neurology 53(4):743–750

    Article  PubMed  Google Scholar 

  • Siegert RJ, Abernethy DA (2005) Depression in multiple sclerosis: a review. J Neurol Neurosurg Psychiatry 76(4):469–475

    Article  PubMed  Google Scholar 

  • Stroud NM, Minahan CL (2009) The impact of regular physical activity on fatigue, depression and quality of life in persons with multiple sclerosis. Health Qual Life Outcomes 7:68

    Article  PubMed  Google Scholar 

  • Thrower BW (2009) Relapse management in multiple sclerosis. Neurologist 15(1):1–5

    Article  PubMed  Google Scholar 

  • Vukusic S, Hutchinson M, Hours M et al (2004) Pregnancy and multiple sclerosis (the PRIMS study): clinical predictors of post-partum relapse. Brain 127:1353–1360

    Article  PubMed  Google Scholar 

  • Weinshenker BG, Bass B, Rice GP et al (1989) The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 112(Pt 1):133–146

    Article  PubMed  Google Scholar 

  • Wiesel PH, Norton C, Glickman S et al (2001) Pathophysiology and management of bowel dysfunction in multiple sclerosis. Eur J Gastroenterol Hepatol 13(4):441–448

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dipartimento Testa-Collo, Azienza Ospedaliera San Camillo Forlanini, Roma, Italia

    C. Gasperini

Authors
  1. C. Gasperini
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  2. S. Ruggieri
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Correspondence to C. Gasperini .

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Editors and Affiliations

  1. Onorario di Psicologia dello Sviluppo e dell’Educazione Dipartimento di Psicologia, Università di Torino, Italia

    Silvia Bonino (Professore) (Professore)

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Gasperini, C., Ruggieri, S. (2013). Evoluzione della malattia. In: Bonino, S. (eds) Aspetti psicologici nella sclerosi multipla. Springer, Milano. https://doi.org/10.1007/978-88-470-2724-4_2

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