Abstract
Major Depressive Disorder (MDD) is very common in patients with Multiple Sclerosis (MS), with a lifetime prevalence of up to 50 % [1]. In the last 15–20 years various studies have revealed that the annual prevalence of MDD in MS is higher compared both to the general population and people with different chronic medical conditions. In MS patients aged between 18 and 45, an annual prevalence of 25.7 % has been reported [2]. Interestingly, psychological distress in MS patients is associated with neurological disability, but is also present in patients with minimal or no neurological disability. Major Depression and affective disturbances in general are identified as an independent predictor for MS-related quality of life [3].
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References
Feinstein A (2004) The neuropsychiatry of multiple sclerosis. Can J Psychiatry 49:157–163
Patten SB, Beck CA, Williams JV, Barbui C, Metz LM (2003) Major depression in multiple sclerosis: a population-based perspective. Neurology. Neurology 9(61):1524–1527
Kern S, Ziemssen T (2008) Brain-immune communication. Psychoneuroimmunology of multiple sclerosis. Mult Scler 14:6–21
Feinstein A (2002) An examination of suicidal intent in patients with multiple sclerosis. Neurology 10(59):674–678
Minden SL, Schiffer RB (1990) Affective disorders in multiple sclerosis. Review and recommendations for clinical research. Arch Neurol 47:98–104
Minden SL, Orav J, Reich P (1987) Depression in multiple sclerosis. Gen Hosp Psychiatry 9:426–434
Joffe RT, Lippert GP, Gray TA, Sawa G, Horvath Z (1987) Mood disorder and multiple sclerosis. Arch Neurol 44:376–378
Sadovnick AD, Remick RA, Allen J, Swartz E, Yee IM, Eisen K, Farquhar R, Hashimoto SA, Hooge J, Kastrukoff LF, Morrison W, Nelson J, Oger J, Paty DW (1996) Depression and multiple sclerosis. Neurology 46:628–632
Chwastiak L, Ehde DM, Gibbons LE, Sullivan M, Bowen JD, Kraft GH (2002) Depressive symptoms and severity of illness in multiple sclerosis: epidemiologic study of a large community sample. Am J Psychiatry 159:1862–1868
Noy S, Achiron A, Gabbay U, Barak Y, Rotstein Z, Laor N, Sarova-Pinhas I (1995) A new approach to affective symptoms in relapsing-remitting multiple sclerosis. Compr Psychiatry 36:390–395
Stenager E, Knudsen L, Jensen K (1994) Multiple sclerosis: correlation of anxiety, physical impairment and cognitive dysfunction. Ital J Neurol Sci 15:97–101
Feinstein A, O’Connor P, Gray T, Feinstein K (1999) The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis. Mult Scler 5:323–326
Stenager EN, Stenager E, Koch-Henriksen N, Brønnum-Hansen H, Hyllested K, Jensen K, Bille-Brahe U (1992) Suicide and multiple sclerosis: an epidemiological investigation. J Neurol Neurosurg Psychiatry 55:542–545
Janssens AC, Buljevac D, van Doorn PA, van der Meché FG, Polman CH, Passchier J, Hintzen RQ (2006) Prediction of anxiety and distress following diagnosis of multiple sclerosis: a two-year longitudinal study. Mult Scler 12:794–801
Korostil M, Feinstein A (2007) Anxiety disorders and their clinical correlates in multiple sclerosis patients. Mult Scler 13:67–72
Arnett PA, Randolph JJ (2006) Longitudinal course of depression symptoms in multiple sclerosis. J Neurol Neurosurg Psychiatry 77:606–610
McCabe MP (2005) Mood and self-esteem of persons with multiple sclerosis following an exacerbation. J Psychosom Res 59:161–166
Amato MP, Zipoli V, Portaccio E (2006) Multiple sclerosis-related cognitive changes: a review of cross-sectional and longitudinal studies. J Neurol Sci 15(245):41–46
Dalos NP, Rabins PV, Brooks BR, O’Donnell P (1983) Disease activity and emotional state in multiple sclerosis. Ann Neurol 13:573–577
Warren S, Warren KG, Cockerill R (1991) Emotional stress and coping in multiple sclerosis (MS) exacerbations. J Psychosom Res 35:37–47
Möller A, Wiedemann G, Rohde U, Backmund H, Sonntag A (1994) Correlates of cognitive impairment and depressive mood disorder in multiple sclerosis. Acta Psychiatr Scand 89:117–121
Brown RF, Tennant CC, Sharrock M, Hodgkinson S, Dunn SM, Pollard JD (2006) Relationship between stress and relapse in multiple sclerosis: Part I Important features. Mult Scler 12:453–464
Sadovnick AD, Eisen K, Ebers GC, Paty DW (1991) Cause of death in patients attending multiple sclerosis clinics. Neurology 41:1193–1196
Klapper JA (1994) Interferon beta treatment of multiple sclerosis. Neurology 44:188
Pandya R, Patten S (2002) Depression in multiple sclerosis associated with interferon beta-1a. Can J Psychiatry 47:686
Jacobs LD, Beck RW, Simon JH, Kinkel RP, Brownscheidle CM, Murray TJ, Simonian NA, Slasor PJ, Sandrock AW (2000) Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group. N Engl J Med 28(343):898–904
Fragoso YD, Frota ER, Lopes JS, Noal JS, Giacomo MC, Gomes S, Gonçalves MV, da Gama PD, Finkelsztejn A (2010) Severe depression, suicide attempts, and ideation during the use of interferon beta by patients with multiple sclerosis. Clin Neuropharmacol 33:312–316
Mohr DC, Goodkin DE, Masuoka L, Dick LP, Russo D, Eckhardt J, Boudewyn AC, Bedell L (1999) Treatment adherence and patient retention in the first year of a Phase-III clinical trial for the treatment of multiple sclerosis. Mult Scler 5:192–197
Patten SB, Metz LM (2001) Interferon beta-1 a and depression in relapsing-remitting multiple sclerosis: an analysis of depression data from the PRISMS clinical trial. Mult Scler 7:243–248
Zephir H, De Seze J, Sénéchal O, Stojkovic T, Ferriby D, Deliss B, Dubus B, Verier A, Hautecoeur P, Vermersch P (2002) Treatment of progressive multiple sclerosis with cyclophosphamide. Rev Neurol (Paris) 158:65–69
Porcel J, Río J, Sánchez-Betancourt A, Arévalo MJ, Tintoré M, Téllez N, Borràs C, Nos C, Montalbán X (2006) Long-term emotional state of multiple sclerosis patients treated with interferon beta. Mult Scler 12:802–807
Ford H, Trigwell P, Johnson M (1998) The nature of fatigue in multiple sclerosis. J Psychosom Res 45:33–38
Kesselring J, Beer S (2005) Symptomatic therapy and neurorehabilitation in multiple sclerosis. Lancet Neurol 4:643–652
Krupp LB, Christodoulou C (2001) Fatigue in multiple sclerosis. Curr Neurol Neurosci Rep 1:294–298
Amato MP, Zipoli V, Goretti B, Portaccio E, De Caro MF, Ricchiuti L, Siracusa G, Masini M, Sorbi S, Trojano M (2006) Benign multiple sclerosis: cognitive, psychological and social aspects in a clinical cohort. J Neurol 253:1054–1059
Vercoulen JH, Swanink CM, Zitman FG, Vreden SG, Hoofs MP, Fennis JF, Galama JM, van der Meer JW, Bleijenberg G (1996) Randomised, double-blind, placebo-controlled study of fluoxetine in chronic fatigue syndrome. Lancet 347:858–861
Téllez N, Río J, Tintoré M, Nos C, Galán I, Montalban X (2006) Fatigue in multiple sclerosis persists over time: a longitudinal study. J Neurol 253:1466–1470
Mohr DC, Hart SL, Goldberg A (2003) Effects of treatment for depression on fatigue in multiple sclerosis. Psychosom Med 65:542–547
Kinsinger SW, Lattie E, Mohr DC (2010) Relationship between depression, fatigue, subjective cognitive impairment, and objective neuropsychological functioning in patients with multiple sclerosis. Neuropsychology 24:573–580
Chiaravalloti ND, DeLuca J (2008) Cognitive impairment in multiple sclerosis. Lancet Neurol 7:1139–1151
Bruce J, Arnett P (2004) Self-reported everyday memory and depression in patients with multiple sclerosis. J Clin Exp Neuropsychol 26:200–214
Randolph JJ, Arnett PA, Freske P (2004) Metamemory in multiple sclerosis: Exploring affective and executive contributors. Arch Clin Neuropsychol 19:259–279
Middleton LS, Denney DR, Lynch SG, Parmenter BA (2006) The relationship between perceived and objective cognitive functioning in multiple sclerosis. Arch Clin Neuropsychol 21:487–494
Rao SM, Leo GJ, Bernardin L, Unverzagt F (1991) Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 41:685–691
Achiron A, Barak Y (2006) Cognitive changes in early MS: a call for a common framework. J Neurol Sci 245:47–51
Jønsson A, Andresen J, Storr L, Tscherning T, Soelberg Sørensen P, Ravnborg M (2006) Cognitive impairment in newly diagnosed multiple sclerosis patients: a 4-year follow-up study. J Neurol Sci 245:77–85
Schulz D, Kopp B, Kunkel A, Faiss JH (2006) Cognition in the early stage of multiple sclerosis. J Neurol 253:1002–1010
Feuillet L, Reuter F, Audoin B, Malikova I, Barrau K, Cherif AA, Pelletier J (2007) Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis. Mult Scler 13:124–127
Feinstein A (2006) Mood disorders in multiple sclerosis and the effects on cognition. J Neurol Sci 245:63–66
Gold SM, Irwin MR (2006) Depression and immunity: inflammation and depressive symptoms in multiple sclerosis. Neurol Clin 24:507–519
Nyenhuis DL, Luchetta T, Yamamoto C et al (1998) The development, standardization, and initial validation of the Chicago multiscale depression inventory. J Pers Assess 70:386–401
Solari A, Motta A, Mendozzi L et al (2003) Italian version of the Chicago Multiscale Depression Inventory: translation, adaptation and testing in people with multiple sclerosis. Neurol Sci 24:375–383
Mohr DC, Hart SL, Fonareva I, Tasch ES (2006) Treatment of depression for patients with multiple sclerosis in neurology clinics. Mult Scler 12:204–208
Goldman Consensus Group (2005) The Goldman Consensus statement on depression in multiple sclerosis. Mult Scler 11:328–337
Cetin K, Johnson KL, Ehde DM, Kuehn CM, Amtmann D, Kraft GH (2007) Antidepressant use in multiple sclerosis: epidemiologic study of a large community sample. Mult Scler 13:1046–1053
Schiffer RB, Wineman NM (1990) Antidepressant pharmacotherapy of depression associated with multiple sclerosis. Am J Psychiatry 147:1493–1497
Mohr DC, Boudewyn AC, Goodkin DE, Bostrom A, Epstein L (2001) Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis. J Consult Clin Psychol 69:942–949
Koch MW, Glazenborg A, Uyttenboogaart M, Mostert J, De Keyser J (2011) Pharmacologic treatment of depression in multiple sclerosis. Cochrane Database Syst Rev 16(2):CD007295
Mohr DC, Likosky W, Bertagnolli A, Goodkin DE, Van Der Wende J, Dwyer P, Dick LP (2000) Telephone-administered cognitive-behavioral therapy for the treatment of depressive symptoms in multiple sclerosis. J Consult Clin Psychol 68:356–361
Mohr DC, Hart SL, Julian L, Catledge C, Honos-Webb L, Vella L, Tasch ET (2005) Telephone-administered psychotherapy for depression. Arch Gen Psychiatry 62:1007–1014
Petajan JH, Gappmaier E, White AT, Spencer MK, Mino L, Hicks RW (1996) Impact of aerobic training on fitness and quality of life in multiple sclerosis. Ann Neurol 39:432–441
Brown TR, Kraft GH (2005) Exercise and rehabilitation for individuals with multiple sclerosis. Phys Med Rehabil Clin N Am 16:513–555
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Siracusano, A., Niolu, C., Sacchetti, L., Ribolsi, M. (2013). Depression and Anxiety. In: Nocentini, U., Caltagirone, C., Tedeschi, G. (eds) Neuropsychiatric Dysfunction in Multiple Sclerosis. Springer, Milano. https://doi.org/10.1007/978-88-470-2676-6_11
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