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Risks Factors in Premature Ejaculation: The Genetic Risk Factor

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Book cover Premature Ejaculation

Abstract

In 1998, it was suggested that the intravaginal ejaculation latency time (IELT) in men with lifelong premature ejaculation (PE) is influenced by neurobiological and genetic factors. Although a familial occurrence of PE has been suggested in 1943 and later also has been investigated in a family study in 1998, there is no real hard evidence today to suggest that being a first-degree relative of a man with lifelong PE is a risk factor for PE. Notably, family studies on PE remain difficult to perform owing to the existing taboo to talk on PE. On the other hand, in 2007, a Finnish twin study suggested a moderate genetic effect on PE in the general male population, but risk factors where not identified. In 2009, a quantified case-control association study in Dutch men with lifelong PE showed that polymorphism of the 5-HT transporter is associated with the IELT in men who ejaculate within 1 min. But based on this study, one can not conclude that having the LL-genotype of this polymorphism is a risk factor for PE. Recently, four premature ejaculation (PE) subtypes have been distinguished on the basis of the duration of the IELT. These four PE subtypes have a different etiology and pathogenesis. Genetic research of PE should consider the existence of these PE subtypes and the accurate measurement of the IELT with a stopwatch.

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Authors and Affiliations

  1. Division Pharmacology, Department of Pharmaceutical Sciences, Faculty of BetaSciences, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands

    Marcel D. Waldinger

  2. Outpatient Department of Neurosexology, HagaHospital, Leyweg 275, 2545 CH, Den Haag, The Netherlands

    Marcel D. Waldinger

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  1. Marcel D. Waldinger
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Correspondence to Marcel D. Waldinger .

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Editors and Affiliations

  1. , Experimental Medicine, University of L'Aquila, Via Vetoio, L'Aquila, 67100, Italy

    Emmanuele A. Jannini

  2. Australian Centre for Sexual Health, Berry Rd St Leonards 1A, Sydney, 2065, New South Wales, Australia

    Chris G. McMahon

  3. Utrecht University, Universiteitsweg 99, Utrecht, 3584, Netherlands

    Marcel D. Waldinger

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Waldinger, M.D. (2013). Risks Factors in Premature Ejaculation: The Genetic Risk Factor. In: Jannini, E., McMahon, C., Waldinger, M. (eds) Premature Ejaculation. Springer, Milano. https://doi.org/10.1007/978-88-470-2646-9_9

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  • DOI: https://doi.org/10.1007/978-88-470-2646-9_9

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2645-2

  • Online ISBN: 978-88-470-2646-9

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