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Pathophysiology of Lifelong Premature Ejaculation

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Premature Ejaculation

Abstract

In 2008, lifelong premature ejaculation (PE) was defined by the ISSM as an ejaculation that occurs within about 1 min, and as an inability to delay ejaculation and with negative personal consequences. The neurophysiology of ejaculation in lifelong PE is intact. However, the core problem in lifelong PE is the timing of ejaculation, which is presumably associated with a dysfunction in the central serotonergic modulation of the spinal ejaculation reflex. This central serotonergic modulation is influenced by genetic polymorphisms of serotonergic neurotransmission and specific serotonergic receptors. As there are four PE subtypes, each with its own clinical characteristics, etiology and pathogenesis, it is assumed that the pathophysiology of lifelong PE is different from the pathophysiology of the other PE subtypes. For a full understanding of the pathophysiology of lifelong PE, there are still many questions that need to be answered by evidence-based human and animal research.

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Authors and Affiliations

  1. Division Pharmacology, Department of Pharmaceutical Sciences, Faculty of Beta Sciences, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands

    Marcel D. Waldinger

  2. Outpatient Department of Neurosexology, HagaHospital, Leyweg 275, 2545 CH, Dan Haag, The Netherlands

    Marcel D. Waldinger

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  1. Marcel D. Waldinger
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Correspondence to Marcel D. Waldinger .

Editor information

Editors and Affiliations

  1. , Experimental Medicine, University of L'Aquila, Via Vetoio, L'Aquila, 67100, Italy

    Emmanuele A. Jannini

  2. Australian Centre for Sexual Health, Berry Rd St Leonards 1A, Sydney, 2065, New South Wales, Australia

    Chris G. McMahon

  3. Utrecht University, Universiteitsweg 99, Utrecht, 3584, Netherlands

    Marcel D. Waldinger

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Waldinger, M.D. (2013). Pathophysiology of Lifelong Premature Ejaculation. In: Jannini, E., McMahon, C., Waldinger, M. (eds) Premature Ejaculation. Springer, Milano. https://doi.org/10.1007/978-88-470-2646-9_6

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  • DOI: https://doi.org/10.1007/978-88-470-2646-9_6

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2645-2

  • Online ISBN: 978-88-470-2646-9

  • eBook Packages: MedicineMedicine (R0)

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