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Imaging of Pediatric Brain and Spinal Cord Tumors

  • Tina Young Poussaint
  • Andrea Rossi

Abstract

Brain tumors are the most common solid pediatric tumors and are the leading cause of death in children from solid tumors [1]. The estimated incidence of all childhood primary brain and central nervous system (CNS) tumors is 4.8 per 100,000 person-years [2]. Approximately 4,150 new cases of childhood primary nonmalignant and malignant brain and CNS tumors will be diagnosed in the United States in 2011 [3]. In neonates, infants, and children up to the age of 3 years, supratentorial tumors are more common.

Keywords

Fractional Anisotropy Pilocytic Astrocytoma Pediatric Brain Tumor Spinal Cord Tumor Childhood Brain Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Gurney J, Smith MA, Bunin G (1999) CNS and miscellaneous intracranial and intraspinal neoplasms. In: Ries LA, Smith M, Gurney J (eds) Cancer incidence and survival among children and adolescents: United States SEER program 1975-1995 NIH Publication No. 99-4649. National Cancer Institute SEER Program, Philadelphia, pp 51–63Google Scholar
  2. 2.
    Kohler BA, Ward E, McCarthy BJ et al (2011) Annual report to the nation on the status of cancer, 1975–2007, featuring tumors of the brain and other nervous system. J Natl Cancer Inst 103:714–736PubMedCrossRefGoogle Scholar
  3. 3.
    CBTRUS (2011) CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2004–2007. Central Brain Tumor Registry of the United States. HinsdaleGoogle Scholar
  4. 4.
    Neglia JP, Meadows AT, Robison LL et al (1991) Second neoplasms after acute lymphoblastic leukemia in childhood. N Engl J Med 325:1330–1336PubMedCrossRefGoogle Scholar
  5. 5.
    Vinchon M, Leblond P, Caron S et al (2011) Radiation-induced tumors in children irradiated for brain tumor: a longitudinal study. Childs Nerv Syst 27:445–453PubMedCrossRefGoogle Scholar
  6. 6.
    Poussaint TY, Rodriguez D (2006) Advanced neuroimaging of pediatric brain tumors: MR diffusion, MR perfusion, and MR spectroscopy. Neuroimaging Clin N Am 16:169–192PubMedCrossRefGoogle Scholar
  7. 7.
    Gauvain KM, McKinstry RC, Mukherjee P et al (2001) Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. AJR Am J Roentgenol 177:449–454PubMedCrossRefGoogle Scholar
  8. 8.
    Hamstra DA, Rehemtulla A, Ross BD (2007) Diffusion magnetic resonance imaging: a biomarker for treatment response in oncology. J Clin Oncol 25:4104–4109PubMedCrossRefGoogle Scholar
  9. 9.
    Qiu D, Kwong DL, Chan GC et al (2007) Diffusion tensor magnetic resonance imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after wholebrain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity? Int J Radiat Oncol Biol Phys 69:846–851PubMedCrossRefGoogle Scholar
  10. 10.
    Seymour ZA, Panigrahy A, Finlay JL et al (2008) Citrate in pediatric CNS tumors? AJNR Am J Neuroradiol 29:1006–1011PubMedCrossRefGoogle Scholar
  11. 11.
    Bluml S, Panigrahy A, Laskov M et al (2011) Elevated citrate in pediatric astrocytomas with malignant progression. Neuro Oncol 13:1107–1117PubMedCrossRefGoogle Scholar
  12. 12.
    Di Costanzo A, Pollice S, Trojsi F et al (2008) Role of perfusion-weighted imaging at 3 Tesla in the assessment of malignancy of cerebral gliomas. Radiol Med 113:134–143PubMedCrossRefGoogle Scholar
  13. 13.
    Ball WS Jr., Holland SK (2001) Perfusion imaging in the pediatric patient. Magn Reson Imaging Clin N Am 9:207–230PubMedGoogle Scholar
  14. 14.
    Lehmann P, Monet P, de Marco G et al (2010) A comparative study of perfusion measurement in brain tumours at 3 Tesla MR: Arterial spin labeling versus dynamic susceptibility contrast-enhanced MRI. Eur Neurol 64:21–26PubMedCrossRefGoogle Scholar
  15. 15.
    Noguchi T, Yoshiura T, Hiwatashi A et al (2008) Perfusion imaging of brain tumors using arterial spin-labeling: correlation with histopathologic vascular density. AJNR Am J Neuroradiol 29:688–693PubMedCrossRefGoogle Scholar
  16. 16.
    Pollack IF (1994) Brain tumors in children. NEJM 331:1500–1507PubMedCrossRefGoogle Scholar
  17. 17.
    Louis DN, Ohgaki H, Wiestler OD et al (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109PubMedCrossRefGoogle Scholar
  18. 18.
    Law M, Yang S, Wang H et al (2003) Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. AJNR Am J Neuroradiol 24:1989–1998PubMedGoogle Scholar
  19. 19.
    Kieran M, Chi SN, Samuel D et al (2009) Tumors of the brain and spinal cord. In: Orkin SH, Fisher DE, Look AT et al (eds) Oncology of Infancy and Childhood. Saunders Elsevier, Philadelphia, pp. 602–685Google Scholar
  20. 20.
    Horska A, Ulug AM, Melhem ER et al (2001) Proton magnetic resonance spectroscopy of choroid plexus tumors in children. J Magn Reson Imaging 14:78–82PubMedCrossRefGoogle Scholar
  21. 21.
    Fleischman A, Brue C, Poussaint TY et al (2005) Diencephalic syndrome: a cause of failure to thrive and a model of partial growth hormone resistance. Pediatrics 115:742–748CrossRefGoogle Scholar
  22. 22.
    Ellison DW (2010) Childhood medulloblastoma: novel approaches to the classification of a heterogeneous disease. Acta Neuropathol 120:305–316PubMedCrossRefGoogle Scholar
  23. 23.
    Kovanlikaya A, Panigrahy A, Krieger MD et al (2005) Untreated Pediatric Primitive Neuroectodermal Tumor in Vivo: Quantitation of Taurine with MR Spectroscopy. Radiology 236:1020–1025PubMedCrossRefGoogle Scholar
  24. 24.
    Pollack IF, Jakacki RI (2011) Childhood brain tumors: epidemiology, current management and future directions. Nat Rev Neurol 7:495–506PubMedCrossRefGoogle Scholar
  25. 25.
    Pollack IF (2011) Multidisciplinary management of childhood brain tumors: a review of outcomes, recent advances, and challenges. J Neurosurg Pediatr 8:135–148PubMedCrossRefGoogle Scholar
  26. 26.
    Roujeau T, Machado G, Garnett MR et al (2007) Stereotactic biopsy of diffuse pontine lesions in children. J Neurosurg 107:1–4PubMedCrossRefGoogle Scholar
  27. 27.
    Hipp SJ, Steffen-Smith E, Hammoud D et al (2011) Predicting outcome of children with diffuse intrinsic pontine gliomas using multiparametric imaging. Neuro Oncol 13:904–909PubMedCrossRefGoogle Scholar
  28. 28.
    Prabhu SP, Ng S, Vajapeyam S et al (2011) DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium. Childs Nerv Syst 27:11–18PubMedCrossRefGoogle Scholar
  29. 29.
    Helton KJ, Edwards M, Steen RG et al (2005) Neuroimagingdetected late transient treatment-induced lesions in pediatric patients with brain tumors. J Neurosurg 102:179–186PubMedCrossRefGoogle Scholar
  30. 30.
    Poussaint TY, Kocak M, Vajapeyam S et al (2011) MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC). Neuro Oncol 13:417–427PubMedCrossRefGoogle Scholar
  31. 31.
    Chen HJ, Panigrahy A, Dhall G et al (2010) Apparent diffusion and fractional anisotropy of diffuse intrinsic brain stem gliomas. AJNR Am J Neuroradiol 31:1879–1885PubMedCrossRefGoogle Scholar
  32. 32.
    Helton KJ, Phillips NS, Khan RB et al (2006) Diffusion tensor imaging of tract involvement in children with pontine tumors. AJNR Am J Neuroradiol 27:786–793PubMedGoogle Scholar
  33. 33.
    Zukotynski KA, Fahey FH, Kocak M et al (2011) Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. J Nucl Med 52:188–195PubMedCrossRefGoogle Scholar
  34. 34.
    Biegel JA (2006) Molecular genetics of atypical teratoid/rhabdoid tumor. Neurosurg Focus 20:E11PubMedCrossRefGoogle Scholar
  35. 35.
    Rumboldt Z, Camacho DL, Lake D et al (2006) Apparent diffusion coefficients for differentiation of cerebellar tumors in children. AJNR Am J Neuroradiol 27:1362–1369PubMedGoogle Scholar
  36. 36.
    Rossi A, Gandolfo C, Morana G et al (2007) Tumors of the spine in children. Neuroimaging Clin N Am 17:17–35PubMedCrossRefGoogle Scholar
  37. 37.
    Jallo GI, Freed D, Epstein F (2003) Intramedullary spinal cord tumors in children. Childs Nerv Syst 19:641–649PubMedCrossRefGoogle Scholar
  38. 38.
    Sandu N, Popperl G, Toubert ME et al (2011) Current molecular imaging of spinal tumors in clinical practice. Mol Med 17:308–316PubMedCrossRefGoogle Scholar
  39. 39.
    Setzer M, Murtagh RD, Murtagh FR et al (2010) Diffusion tensor imaging tractography in patients with intramedullary tumors: comparison with intraoperative findings and value for prediction of tumor resectability. J Neurosurg Spine 13:371–380PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Tina Young Poussaint
    • 1
  • Andrea Rossi
    • 2
  1. 1.Department of RadiologyHarvard Medical School and Children’s Hospital BostonBostonUSA
  2. 2.Neuroradiology DepartmentG. Gaslini Children’s HospitalGenoaItaly

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