Abstract
In a study published in 1961, Lerish was able to demonstrate the effects of an injury on the circulation in the involved extremity: a short period of spasm is followed by active vasodilation combined with local hyperemia [796]. Later, vasoactive amines were shown to play a substantial role in the pathogenesis of injury and inflammation. As a number of authors have since confirmed, an impairment of tissue integrity, regardless of the etiology, sets off an inflammatory process [107, 797–799]. This reactive process comprises a sequence of complex alterations in the microcirculation—as well as in the blood circulation as a whole and in conjunctive tissues—that is aimed at localizing and eventually eradicating the harmful agent and at restoring (or replacing) the damaged tissue [798, 800].
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Shatokhin, V.D. (2012). External Fixation in the Treatment of Chronic Limb Ischemia. In: Solomin, L. (eds) The Basic Principles of External Skeletal Fixation Using the Ilizarov and Other Devices. Springer, Milano. https://doi.org/10.1007/978-88-470-2619-3_31
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DOI: https://doi.org/10.1007/978-88-470-2619-3_31
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