Abstract
Ultrasound contrast agents can be divided into first-generation and second-generation agents. First generation hand-agitated saline solutions contain large and unstable air microbubbles which cannot pass through the pulmonary microcirculation and are used only for the opacification of the right side of the heart. These agents have been used for about 40 years to rule out a shunt at the level of the fossa ovalis. Second-generation agents are made of smaller, more standardized and stable microbubbles containing a low-diffusable gas. They can easily cross the pulmonary circulation and provide left ventricular cavity and left ventricular myocardial opacification. These agents are used for better delineation of the endocardial contour and for myocardial perfusion studies.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Further Reading
Agati L, Funaro S, Madonna MP, Sardella G, Garramone B, Galiuto L (2007) Does coronary angioplasty after timely thrombolysis improve microvascular perfusion and left ventricular function after acute myocardial infarction? Am Heart J 154:15127
Agati L, Tonti G, Galiuto L, Di Bello V, Funaro S, Madonna MP, Garramone B, Magri F (2005) Quantification methods in contrast echocardiography. Eur J Echocardiogr 6(Suppl 2):S14–S20
Feinstein SB, Voci P, Segil LJ, Harper PV (1991) Contrast echocardiography. In: Marcus ML, Skorton DJ, Wolf GL (eds) Cardiac imaging. A companion to Braunwald’s heart disease. Saunders, Philadelphia, pp 557–574
Galiuto L, Garramone B, Scarà A, Rebuzzi AG, Crea F, La Torre G, Funaro S, Madonna MP, Fedele F, Agati L (2008) The extent of microvascular damage during myocardial contrast echocardiography is superior to other known indexes of post-infarct reperfusion in predicting left ventricular remodeling. J Am Coll Cardiol 51:552–559
Pizzuto F, Voci P, Mariano E, Puddu PE, Aprile A, Romeo F (2005) Evaluation of flow in the left anterior descending coronary artery but not in the left internal mammary artery graft predicts significant stenosis of the arterial conduit. J Am Coll Cardiol 45:424–432
Voci P (2000) The bubbles and the science of life. J Am Coll Cardiol 36:625–627
Voci P, Testa G, Tritapepe L (1996) Demonstration of false lumen perfusion during repair of type A aortic dissection. Anesthesiology 85:926–928
Voci P, Pizzuto F, Romeo F (2004) Coronary flow: a new asset for the echo lab? Eur Heart J 25:1867–1879
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Italia
About this chapter
Cite this chapter
Voci, P., Tritapepe, L., Tallarico, D., Agati, L. (2013). Contrast Echocardiography in the ICU and OR. In: Sarti, A., Lorini, F. (eds) Echocardiography for Intensivists. Springer, Milano. https://doi.org/10.1007/978-88-470-2583-7_26
Download citation
DOI: https://doi.org/10.1007/978-88-470-2583-7_26
Published:
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2582-0
Online ISBN: 978-88-470-2583-7
eBook Packages: MedicineMedicine (R0)