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Chronic Obstructive Pulmonary Disease (COPD): Neuromuscular Implications

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Long-Term Oxygen Therapy

Abstract

Oxygen is necessary for the correct functioning of the whole nervous system, including its peripheral component, muscles and nerves. Although there are some data in the literature showing that the lack of oxygen impairs this correct functioning of muscles and nerves, as we will illustrate, to the best of our knowledge there are no data regarding whether oxygen therapy may prevent and reverse this damage.

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References

  1. Appenzeller O, Parks RD, MacGee J (1968) Peripheral neuropathy in chronic disease of the respiratory tract. Am J Med 44:873–880

    Article  PubMed  CAS  Google Scholar 

  2. Chedru F, Nodzenski R, Dunand JF et al (1985) Peripheral neuropathy during treatment with almitrine. Br Med J (Clin Res Ed) 290(6472):896

    Article  CAS  Google Scholar 

  3. Gherardi R, Louarn F, Benvenuti C et al (1985) Peripheral neuropathy in patients treated with almitrine dimesylate. Lancet 1:1247–1250

    Article  PubMed  CAS  Google Scholar 

  4. Gherardi R, Baudrimont M, Gray F, Louarn F (1987) Almitrine neuropathy. A nerve biopsy study of 8 cases. Acta Neuropathol 73:202–208

    Article  PubMed  CAS  Google Scholar 

  5. Moore N, Lerebours G, Senant J et al (1985) Peripheral neuropathy in chronic obstructive lung disease. Lancet 2(8467): 1311

    Article  PubMed  CAS  Google Scholar 

  6. Suggett AJ, Jarratt JA, Proctor A, Howard P (1985) Almitrine and peripheral neuropathy. Lancet 2:830–831

    Article  PubMed  CAS  Google Scholar 

  7. Allen MB, Prowse K (1989) Peripheral nerve function in patients with chronic bronchitis receiving almitrine or placebo. Thorax 44:292–297

    Article  PubMed  CAS  Google Scholar 

  8. Winkelmann BR, Kullmer TH, Kneissl DG et al (1994) Low-dose almitrine bismesylate in the treatment of hypoxemia due to chronic obstructive pulmonary disease. Chest 105:1383–1391

    Article  PubMed  CAS  Google Scholar 

  9. Valli G, Barbieri S, Sergi P et al (1984) Evidence of motor neuron involvement in chronic respiratory insufficiency. J Neurol Neurosurg Psychiatry 47:1117–1121

    Article  PubMed  CAS  Google Scholar 

  10. Gelfan S, Tarlov IM (1956) Physiology of spinal cord, nerve root and peripheral nerve compression. Am J Physiol 185:217–229

    PubMed  CAS  Google Scholar 

  11. Ozge A, Atiş S, Sevim S (2001) Subclinical peripheral neuropathy associated with chronic obstructive pulmonary disease. Electromyogr Clin Neurophysiol 41:185–191

    PubMed  CAS  Google Scholar 

  12. Nukada H, Dyck PJ, Low PA et al (1986) Axonal caliber and neurofilaments are proportionately decreased in galactose neuropathy. J Neuropathol Exp Neurol 45:140–150

    Article  PubMed  CAS  Google Scholar 

  13. Faden A, Mendoza E, Flynn F (1981) Subclinical neuropathy associated with chronic obstructive pulmonary disease: possible pathophysiologic role of smoking. Arch Neurol 38:639–642

    Article  PubMed  CAS  Google Scholar 

  14. Jarratt JA, Morgan CN, Twomey JA et al (1992) Neuropathy in chronic obstructive pulmonary disease: a multicentre electrophysiological and clinical study. Eur Respir J 5:517–524

    PubMed  CAS  Google Scholar 

  15. Jann S, Gatti A, Crespi S et al (1998) Peripheral neuropathy in chronic respiratory insufficiency. J Peripher Nerv Syst 3:69–74

    PubMed  CAS  Google Scholar 

  16. Agrawal D, Vohra R, Gupta PP, Sood S (2007) Subclinical peripheral neuropathy in stable middle-aged patients with chronic obstructive pulmonary disease. Singapore Med J 48:887–894

    PubMed  CAS  Google Scholar 

  17. Nowak D, Brüch M, Arnaud F et al (1990) Peripheral neuropathies in patients with chronic obstructive pulmonary disease: a multicenter prevalence study. Lung 168:43–51

    Article  PubMed  CAS  Google Scholar 

  18. Pfeiffer G, Kunze K, Brüch M et al (1990) Polyneuropathy associated with chronic hypoxemia: prevalence in patients with chronic obstructive pulmonary disease. J Neurol 237:230–233

    Article  PubMed  CAS  Google Scholar 

  19. Oncel C, Baser S, Cam M et al (2010) Peripheral neuropathy in chronic obstructive pulmonary disease. COPD 7:11–16

    Article  PubMed  Google Scholar 

  20. Mayer P, Dematteis M, Pépin JL et al (1999) Peripheral neuropathy in sleep apnea. A tissue marker of the severity of nocturnal desaturation. Am J Respir Crit Care Med159:213–219

    Article  PubMed  CAS  Google Scholar 

  21. Stoebner P, Mezin P, Vila A et al (1989) Microangiopathy of endoneurial vessels in hypoxemic chronic obstructive pulmonary disease (COPD). A quantitative ultrastructural study. Acta Neuropathol 78:388–395

    Article  PubMed  CAS  Google Scholar 

  22. Simpson LL, Curtis DR (1974) Neuropoisons: their pathophysioogical actions. New York, Plenum Press, Vol. 2, pp 61–97

    Google Scholar 

  23. Kayacan O, Beder S, Deda G, Karnak D (2001) Neurophysiological changes in COPD patients with chronic respiratory insufficiency. Acta Neurol Belg 101:160–165

    PubMed  CAS  Google Scholar 

  24. Kent BD, Mitchell PD, McNicholas WT (2011) Hypoxemia in patients with COPD: cause, effects, and disease progression. Int J Chron Obstruct Pulmon Dis 6:199–208. Epub 2011 Mar 14

    PubMed  Google Scholar 

  25. Kim HC, Mofarrahi M, Hussain SN (2008) Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 3:637–658

    PubMed  Google Scholar 

  26. Wüst RC, Degens H (2007) Factors contributing to muscle wasting and dysfunction in COPD patients Int J Chron Obstruct Pulmon Dis 2:289–300

    Google Scholar 

  27. Davidson AC, Leach R, George RJ, Geddes DM (1988) Supplemental oxygen and exercise ability in chronic obstructive airways disease. Thorax 43:965–971

    Article  PubMed  CAS  Google Scholar 

  28. Mercken EM, Hageman GJ, Langen RC et al (2011) Decreased exercise-induced expression of nuclear factor-κB-regulated genes in muscle of patients with COPD. Chest 139:337–46. Epub 2010 Aug 5

    Article  PubMed  Google Scholar 

  29. Vogiatzis I, Simoes DC, Stratakos G et al (2010) Effect of pulmonary rehabilitation on muscle remodelling in cachectic patients with COPD. Eur Respir J 36:301–10. Epub 2010 Jan 28

    Article  PubMed  CAS  Google Scholar 

  30. Turan N, Kalko S, Stincone A et al (2011) A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease. PLoS Comput Biol 7(9):e1002129. Epub 2011 Sep 1

    Article  PubMed  CAS  Google Scholar 

  31. Amaya-Villar R, Garnacho-Montero J, García-Garmendía JL et al (2005) Steroid-induced myopathy in patients intubated due to exacerbation of chronic obstructive pulmonary disease. Intensive Care Med 31:157–161. Epub 2004 Dec 4

    Article  PubMed  Google Scholar 

  32. Pouw EM, Koerts-de Lang E, Gosker HR et al (2000) Muscle metabolic status in patients with severe COPD with and without long-term prednisolone. Eur Respir J 16:247–252

    Article  PubMed  CAS  Google Scholar 

  33. Barreiro E, Peinado VI, Galdiz JB et al; ENIGMA in COPD Project (2000) Cigarette smoke-induced oxidative stress: A role in chronic obstructive pulmonary disease skeletal muscle dysfunction. Am J Respir Crit Care Med 182(4):477–88. Epub 2010 Apr 22

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Maria Grazia Passarin .

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© 2012 Springer-Verlag Italia

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Deluca, C., Buffone, E., Minguzzi, E., Passarin, M.G. (2012). Chronic Obstructive Pulmonary Disease (COPD): Neuromuscular Implications. In: Dal Negro, R.W., Hodder, R. (eds) Long-Term Oxygen Therapy. Springer, Milano. https://doi.org/10.1007/978-88-470-2580-6_4

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  • DOI: https://doi.org/10.1007/978-88-470-2580-6_4

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2579-0

  • Online ISBN: 978-88-470-2580-6

  • eBook Packages: MedicineMedicine (R0)

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