Abstract
Phosphatidylinositol 4,5-bisphosphate (PIP2) is the predominant (99%) phosphoinositide in mammalian cells [7]. PIP2 is synthesized from phosphatidylinositol-4- phosphate (PIP) by PIP2 synthases while PIP is synthesized from Phosphatidylinositol (PI) by PIP synthases. PIP2 in cells is normally hydrolyzed by phospholipase C (PLC) to generate inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG),which serve as second messengers for intracellular Ca2+ mobilization and PKC (protein kinase C) activation, respectively [4, 7]. Thus, PIP2 plays important roles in PLCmediated cellular processes, such as glucose-stimulated insulin secretion [1], storeoperated calcium entry [2, 6], and sterol trafficking [5, 8]. Mathematical models for the process of phosphoinositide synthesis have been established (see, e.g., [3, 7]). In this chapter, we present the model developed by Xu et al [7] because of its simplicity.
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Liu, W. (2012). Control of Phosphoinositide Synthesis. In: Introduction to Modeling Biological Cellular Control Systems. MS&A. Springer, Milano. https://doi.org/10.1007/978-88-470-2490-8_10
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DOI: https://doi.org/10.1007/978-88-470-2490-8_10
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-2489-2
Online ISBN: 978-88-470-2490-8
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