Excessive Nutrients and Regional Energy Metabolism


There is general agreement that type 2 diabetes is the consequence of insulin resistance, defined as an impaired ability of insulin to control hepatic and peripheral glucose metabolism, and of compromised pancreatic β-cell function such that insulin secretion is insufficient to compensate the degree of insulin resistance [1]. The pivotal role of insulin resistance is confirmed by the fact that it is a consistent finding in patients with type 2 diabetes. Indeed, insulin resistance may be detected 10–20 years before the onset of overt hyperglycemia and prospective studies have demonstrated that it is the best predictor of whether an individual will later become diabetic [2].


Insulin Resistance Nonalcoholic Fatty Liver Disease Myotonic Dystrophy Type Intramyocellular Lipid Regional Energy Metabolism 
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© Springer-Verlag Italia 2012

Authors and Affiliations

  1. 1.Division of Metabolic and Cardiovascular SciencesIstituto Scientifico San RaffaeleMilanItaly
  2. 2.Department of Sport Sciences, Nutrition and HealthUniversity of MilanMilanItaly

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