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Physical Activity and Inflammation

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Book cover Cellular Physiology and Metabolism of Physical Exercise

Abstract

Diabetes mellitus, referred to simply as diabetes, is a serious metabolic disorder that affects millions of people worldwide [1, 2]. It is caused by defects in insulin production, insulin secretion, and insulin signaling, all of which result in abnormally high blood sugar levels [3]. Diabetes patients usually develop serious secondary complications, especially involving the microvasculature but also cardiovascular disease, retinal damage, nerve damage, and kidney failure [4]. The two principal idiopathic forms of diabetes are known as types 1 and 2. Type 1 diabetes (T1D) is due to an autoimmune attack that leads to self-destruction of the insulin-producing β-cells of the pancreas. Type 2 diabetes (T2D) is caused by defects in insulin action and production, leading to insulin resistance, dyslipidemia, and impaired insulin secretion.

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Authors and Affiliations

  1. Harvard Medical School, Boston, USA

    Paolo Fiorina MD PhD (Assistant Professor)

  2. Department of Medicine, Istituto Scientifico San Raffaele, Milan, Italy

    Raffaele Di Fenza & Paolo Fiorina MD PhD (Assistant Professor)

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  1. Raffaele Di Fenza
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  2. Paolo Fiorina MD PhD
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Correspondence to Paolo Fiorina MD PhD .

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  1. Department of Sport Sciences, Nutrition and Health, University of Milan, Milan, Italy

    Livio Luzi

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Di Fenza, R., Fiorina, P. (2012). Physical Activity and Inflammation. In: Luzi, L. (eds) Cellular Physiology and Metabolism of Physical Exercise. Springer, Milano. https://doi.org/10.1007/978-88-470-2418-2_10

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