The History of Experimental Heterotopic and Orthotopic Heart Transplantation Before Cardiopulmonary Bypass

  • Tyson A. Fricke
  • Igor E. Konstantinov


Early experimental research in heart transplantation was conducted before the advent of the cardiopulmonary bypass. Carrel (1873–1944) was the first to perform a heterotopic transplant of the heart of a warm-blooded animal. Subsequently, Demikhov (1916–1998) performed the first orthotopic heart transplantation.


Cardiopulmonary Bypass Heart Transplantation Lung Transplantation Donor Heart Vascular Anastomosis 
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Copyright information

© Springer-Verlag Italia 2013

Authors and Affiliations

  1. 1.Cardiothoracic Surgery, Royal Children’s HospitalUniversity of MelbourneMelbourneAustralia

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