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From Research on Hibernation and Hypothermia to Recent Advances in Cardiopulmonary Bypass

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Dawn and Evolution of Cardiac Procedures

Abstract

For many years, progress in cardiac surgery were limited by the inability to operate within the empty heart under direct vision. There have been several methods devised in the effort to obtain intracardiac exposure with a dry field. The early models of heart-lung machines developed were not widely applicable with safety to the human patient. The other avenue of approach has been the attempt to reduce the metabolic demand until circulation can be interrupted for periods of time long enough without recourse to extracorporeal pumps. General hypothermia has been investigated as a means of reducing the oxygen requirements of the body to allow deliberate and extensive intracardiac maneuvers.

I was taught that the way of progress was neither swift nor easy.

Marie Curie

I do not think that the practice of science can be separated from courage.

Berthold Brecht

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References

  1. No authors listed (1941) Treatment by hypothermia. Br Med J 2(4206): 231–232

    Google Scholar 

  2. Talbott JH (1941) The physiologic and therapeutic effects of hypothermia. N Engl J Med 224(7):281–288

    Article  Google Scholar 

  3. Bigelow WG, Lindsay WK et al (1950) Oxygen transport and utilization in dogs at low body temperatures. Am J Physiol 160(1):125–137

    CAS  PubMed  Google Scholar 

  4. Penrod KE (1949) Oxygen consumption and cooling rates in immersion hypothermia in the dog. Am J Physiol 157(3):436–444

    CAS  PubMed  Google Scholar 

  5. Adolph EF (1951) Responses to hypothermia in several species of infant mammals. Am J Physiol 166(1):75–91

    CAS  PubMed  Google Scholar 

  6. Bigelow WG, Mcbirnie JE (1953) Further experiences with hypothermia for intracardiac surgery in monkeys and groundhogs. Ann Surg 137(3):361–365

    Article  CAS  PubMed  Google Scholar 

  7. Prec O, Rosenman R, Braun K, Rodbard S, Katz LN (1949) The cardiovascular effects of acutely induced hypothermia. J Clin Invest 28(2):293–300

    Article  PubMed Central  Google Scholar 

  8. Bigelow WG, Lindsay WK, Greenwood WF (1950) Hypothermia; its possible role in cardiac surgery: an investigation of factors governing survival in dogs at low body temperatures. Ann Surg 132(5):849–866

    Article  CAS  PubMed  Google Scholar 

  9. Baffes TG (1958) Hypothermia in cardiovascular surgery. J Natl Med Assoc 50(6):426–428

    CAS  PubMed  Google Scholar 

  10. Boerema I, WildschutI A, Schmidt WJ, Broekhuysen L (1951) Experimental researches into hypothermia as an aid in the surgery of the heart. Arch Chir Neerl 3(1):25–34

    CAS  PubMed  Google Scholar 

  11. Cookson BA, Neptune WB, Bailey CP (1952) Hypothermia as a means of performing intracardiac surgery under direct vision. Dis Chest 22(3):245–260

    Article  CAS  PubMed  Google Scholar 

  12. Lewis FJ, Taufic M (1953) Closure of atrial septal defects with the aid of hypothermia; experimental accomplishments and the report of one successful case. Surgery 33(1):52–59

    CAS  PubMed  Google Scholar 

  13. Sellors JH (1967) The genesis of heart surgery. Br Med J 1(5537):385–393

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Swan H, Zeavin I, Blount SG Jr, Virtue RW (1953) Surgery by direct vision in the open heart during hypothermia. J Am Med Assoc 153(12):1081–1085

    Article  CAS  PubMed  Google Scholar 

  15. Lewis FJ (1956) Hypothermia in surgery. J Natl Med Assoc 48(5):317–322

    CAS  PubMed  Google Scholar 

  16. No authors listed (1953) Hypothermia. Br Med J 2(4848):1256–1257

    Google Scholar 

  17. Blades B, Pierpont HC (1954) A simple method for inducing hypothermia. Ann Surg 140(4):557–563

    Article  CAS  PubMed  Google Scholar 

  18. Delorme EJ (1952) Experimental cooling of the blood-stream. Lancet 2(6741):914–915

    Article  CAS  PubMed  Google Scholar 

  19. Brock R (1956) Hypothermia and open cardiotomy. Proc R Soc Med 49(6):347–352

    CAS  PubMed  Google Scholar 

  20. Smith A, Fairer JG (1953) Hibernation anaesthesia in major surgery; a report of 36 cases. Br Med J 2(4848):1247–1248

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Lucas BG (1956) Discussion on the application of hypothermia to surgical procedures. Proc R Soc Med 49(6):345–347

    CAS  PubMed  Google Scholar 

  22. Swan H, Zeavin I, Holmes JH, Montgomery V (1953) Cessation of circulation in general hypothermia. I. Physiologic changes and their control. Ann Surg 138(3):360–376

    CAS  PubMed  Google Scholar 

  23. Shumacker HB (1992) The evolution of cardiac surgery. Indiana University Press, Bloomington

    Google Scholar 

  24. Gravlee GP, Davis RF, Kurusz M, Utley JR (2000) Cardiopulmonary bypass: principles and practice, 2nd edn. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  25. Ranucci M, Balduini A, Ditta A, Boncilli A, Brozzi S (2009) A systematic review of biocompatible cardiopulmonary bypass circuits and clinical outcome. Ann Thorac Surg 87:1311–1319

    Article  PubMed  Google Scholar 

  26. Mahoney CB (1998) Heparin-bonded circuits: clinical outcome and costs. Perfusion 13:1892

    Article  Google Scholar 

  27. Ranucci M, Mazzucco A, Pessotto R et al (1999) Heparin-coated circuits for high-risk patients: a multi-center prospective randomized trial. Ann Thorac Surg 67:994

    Article  CAS  PubMed  Google Scholar 

  28. DeSomer F, VanBelleghem Y, Cases F et al (2002) Phosphorylcholine coating offers natural platelet preservation during CPB. Perfusion 17:39

    Article  CAS  Google Scholar 

  29. Taketani S, Sawa Y, Massai T et al (1998) A novel technique for cardiopulmonary bypass using vacuum system for venous drainage with pressure relief valve: an experimental study. Artif Organs 22:337

    Article  CAS  PubMed  Google Scholar 

  30. La Pietra A, Groggi EA, Pua BB et al (2000) Assisted venous drainage presents the risk of undetected air microembolism. J Thorac Cardiovasc Surg 120:856

    Article  Google Scholar 

  31. Biancari F, Rimpiläinen R (2009) Meta-analysis of randomised trials comparing the effectiveness of miniaturised versus conventional cardiopulmonary bypass in adult cardiac surgery. Heart 95(12):964–969

    Article  CAS  PubMed  Google Scholar 

  32. Gu YJ, de Vries AJ, Voa P et al (1999) Leukocyte depletion during cardiac operations: a new approach through the venous bypass circuit. Ann Thorac Surg 67:604

    Article  CAS  PubMed  Google Scholar 

  33. Hessel EA II (2001) Cardiopulmonary bypass equipment. In: Estafanous FG, Barash PG, Reves JG (eds) Cardiac anesthesia: principles and clinical practice, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, p 335

    Google Scholar 

  34. High KM, Williams DR, Kurusz M (1995) Cardiopulmonary bypass circuits and design. In: Hensley FA Jr, Martin DE (eds) A practical approach to cardiac anesthesia, 2nd edn. Little, Brown, Boston, p 465

    Google Scholar 

  35. Stammers AH (1998) Monitoring controversies during cardiopulmonary bypass: how far have we come? Perfusion 13:35

    Article  CAS  PubMed  Google Scholar 

  36. Baraka A, Barody M, Harous S et al (1990) Continuous venous oximetry during cardiopulmonary bypass: influence of temperature changes, perfusion flow and hematocrit level. J Cardiothorac Anesth 4:35

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Isabelle Plamondon .

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Plamondon, I., Gasparotto, E. (2013). From Research on Hibernation and Hypothermia to Recent Advances in Cardiopulmonary Bypass. In: Picichè, M. (eds) Dawn and Evolution of Cardiac Procedures. Springer, Milano. https://doi.org/10.1007/978-88-470-2400-7_13

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  • DOI: https://doi.org/10.1007/978-88-470-2400-7_13

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  • Publisher Name: Springer, Milano

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  • Online ISBN: 978-88-470-2400-7

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