Pancreatic Lesions: Pathologic Correlations

  • Paola Capelli
  • Alice Parisi


In recent years the evolution of imaging technology has made possible a more detailed identification of the structural features of pancreatic cancers, facilitating the differential diagnosis between different tumor histologies and pancreatic diseases in relation to other tumor-forming lesions. At the same time pathologists have provided a most accurate definition of the different tumor histologies with the development of the most recent WHO classification (2010) [1].


Acinar Cell Cystic Lesion Acinar Cell Carcinoma Accessory Spleen Mucinous Cystic Neoplasm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Bosman FT, Carneiro F, Hruban RH et al (2010) Tumors of the pancreas. In: WHO classification of Tumors of the digestive system. IARC, Lyon, pp 279–334Google Scholar
  2. 2.
    Klimstra DS, Pitman MB, Hruban RH (2009) An algorithmic approach to the diagnosis of pancreatic neoplasms. Arch Pathol Lab Med 133:454–464PubMedGoogle Scholar
  3. 3.
    Capelli P, Martignoni G, Pedica F et al (2009) Endocrine neoplasm of the pancreas. Arch Pathol Lab Med 33:350–364Google Scholar
  4. 4.
    Lloyd RV, Mervak T, Schmidt K et al (1984) Immunohistochemical detection of chromogranin and neuron-specific enolase in pancreatic endocrine neoplasms. Am J Surg Pathol 8:607–614PubMedCrossRefGoogle Scholar
  5. 5.
    Ordonez NG (2001) Pancreatic acinar cell carcinoma. Adv Anat Pathol 8:144–159PubMedCrossRefGoogle Scholar
  6. 6.
    Klimstra DS, Heffess CS, Oertel JE et al (1992) Acinar cell carcinoma of the pancreas: a clinicopathologic study of 28 cases. Am J Surg Pathol 16:815–837PubMedCrossRefGoogle Scholar
  7. 7.
    Klimstra DS, Wenig BM, Adair CF et al (1995) Pancreatoblastoma: a clinicopathologic study and review of the literature. Am J Surg Pathol 19:1371–1389PubMedCrossRefGoogle Scholar
  8. 8.
    Adsay NV, Andea A, Basturk O et al (2004) Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literature. Virchows Arch 444:527–535PubMedCrossRefGoogle Scholar
  9. 9.
    Adsay NV, Basturk O, Klimstra DS et al (2004) Pancreatic pseudotumors: non-neoplastic solid lesions of the pancreas that clinically mimic pancreas cancer. Sem Diagn Pathol 21:260–267CrossRefGoogle Scholar
  10. 10.
    Zamboni G, Capelli P, Scarpa A et al (2009) Nonneoplastic mimickers of pancreatic neoplasms. Arch Pathol Lab Med 133:439–453PubMedGoogle Scholar
  11. 11.
    Zamboni G, Lüttges J, Capelli P et al (2004) Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens. Virchows Arch 445:552–563PubMedCrossRefGoogle Scholar
  12. 12.
    Kosmahl M, Pauser U, Peters K et al (2004) Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal. Virchows Arch 445:168–178PubMedCrossRefGoogle Scholar
  13. 13.
    Adsay NV, Klimstra DS, Compton CC (2000) Cystic lesions of the pancreas. Introduction. Semin Diagn Pathol 17:1–6PubMedGoogle Scholar
  14. 14.
    Yasuhara Y, Sakaida N, Uemura Y et al (2002) Serous microcystic adenoma (glycogen-rich cystadenoma) of the pancreas: study of 11 cases showing clinicopathological and immunohistochemical correlations. Pathol Int 52:307–312PubMedCrossRefGoogle Scholar
  15. 15.
    Zamboni G, Scarpa A, Bogina G et al (1999) Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol 23:410–422PubMedCrossRefGoogle Scholar
  16. 16.
    Edge SB, Byrd DR, Compton CC et al (2010) Exocrine and endocrine pancreas. In: AJCC Cancer Staging Manual. 7th edn. New York: Springer 24:285–296Google Scholar
  17. 17.
    Adsay NV, Longnecker DS, Klimstra DS (2000) Pancreatic tumors with cystic dilatation of the ducts: intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms. Semin Diagn Pathol 17:16–30PubMedGoogle Scholar
  18. 18.
    Klöppel G (1998) Clinicopathologic view of intraductal papillary-mucinous tumor of the pancreas. Hepatogastroenterology 45:1981–1985PubMedGoogle Scholar
  19. 19.
    Crippa S, Partelli S, Falconi M (2010) Extent of surgical resections for intraductal papillary mucinous neoplasms. World J Gastrointest Surg 2:347–351PubMedCrossRefGoogle Scholar
  20. 20.
    Zamboni G, Capelli P, Bogina G et al (2003) Pathology of intraductal cystic tumors. In: Procacci C, Megibow AJ (eds) Imaging of the pancreas. Cystic and rare tumors. Springer, Berlin Heidelberg New York, pp 85–94Google Scholar
  21. 21.
    Furukawa T, Klöppel G, Adsay NV et al (2005) Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study. Virchows Arch 447:794–799PubMedCrossRefGoogle Scholar
  22. 22.
    Basturk O, Zamboni G, Klimstra DS et al (2007) Intraductal and papillary variants of acinar cell carcinomas: a new addition to the challenging differential diagnosis of intraductal neoplasm. Am J Surg Path 31:363–370PubMedCrossRefGoogle Scholar
  23. 23.
    Colombo P, Arizzi C, Roncalli M (2004) Acinar cell cystadenocarcinoma of the pancreas: report of rare case and review of the literature. Hum Pathol 35:1568–1571PubMedCrossRefGoogle Scholar
  24. 24.
    Zamboni G, Terris B, Scarpa A et al (2002) Acinar cell cystadenoma of the pancreas: a new entity? Am J Surg Pathol 26: 698–704PubMedCrossRefGoogle Scholar
  25. 25.
    Adsay NV, Klimstra DS (2000) Cystic forms of typically solid pancreatic tumors. Semin Diagn Pathol 17:66–81Google Scholar
  26. 26.
    Klimstra DS, Wenig BM, Heffess CS (2000) Solid-pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential. Semin Diagn Pathol 17:66–80PubMedGoogle Scholar
  27. 27.
    Lee LY, Hsu HL, Chen HM et al (2003) Ductal adenocarcinoma of the pancreas with huge cystic degeneration: a lesion to be distinguished from pseudocyst and mucinous cystadenocarcinoma. Int J Surg Pathol 11:235–239PubMedCrossRefGoogle Scholar
  28. 28.
    Ligneau B, Lombard-Bohas C, Partensky C et al (2001) Cystic endocrine tumors of the pancreas: clinical, radiologic, and histopathologic features in 13 cases. Am J Surg Pathol 25:752–760PubMedCrossRefGoogle Scholar
  29. 29.
    Basturk O, Coban I, Adsay NV (2009) Pancreatic cysts. Arch Pathol Lab Med 133:423–438PubMedGoogle Scholar
  30. 30.
    Klöppel G (2000) Pseudocysts and other non-neoplastic cysts of the pancreas. Semin Diagn Pathol 17:1–7Google Scholar
  31. 31.
    Adsay N, Zamboni G (2005) Paraduodenal pancreatitis: a clinico-pathologically distinct entity unifying ‘cystic dystrophy of heterotopic pancreas’, ‘para-duodenal wall cyst’ and ‘groove pancreatitis’. Semin Diagn Pathol 21:247–254CrossRefGoogle Scholar
  32. 32.
    Procacci C, Graziani R, Zamboni G et al (1997) Cystic dystrophy of the duodenal wall: radiologic findings. Radiology 205:741–747PubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  1. 1.Department of PathologyG.B. Rossi University HospitalVeronaItaly

Personalised recommendations