Post Radiation-therapy Morphologic MR Imaging

  • Mario Muto
  • Saverio Pollice
  • Tommaso Scarabino


Radiation therapy (RT) is responsible for cellular damage that affects not only cancer cells but also healthy brain and endothelial cells causing toxic effects on enzyme systems. These effects continue in the targeted organ for many months to reach the optimal performance after at least 3–6 months and in some cases, years after the end of treatment, although effects on healthy cells persist over time. In many cases post-RT alterations are associated with concomitant chemotherapy changes which strengthen the harmful effect.


White Matter Intracranial Hypertension Optic Neuritis Radiation Necrosis Periventricular White Matter 
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    Edelman RR, Hesselink JR, Zlatkin MB et al (2006) Clinical magnetic resonance imaging. Saunders, PhiladelphiaGoogle Scholar
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    Kumar AJ, Leeds NE, Fuller GN et al (2000) Malignant gliomas: MR imaging spectrum of radiation therapy — and chemotherapy-induced necrosis of the brain after treatment. Radiology 217:377–384PubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Mario Muto
    • 1
  • Saverio Pollice
  • Tommaso Scarabino
  1. 1.Department of Neuroradiology“Cardarelli” HospitalNaplesItaly

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