Abstract
This chapter considers the histology of the terminal ileum and cecal region in different pathological conditions. After reviewing the normal histological aspect of this intestinal segment, we continue with a discussion of several different pathologies, such as Crohn’s disease, backwash ileitis and pouchitis, inflammatory bowel disease, ischemia, and celiac disease, rarer entities, and tumors that involve this anatomic region.
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References
Hayat M, Cairns A, Dixon MF, O’Mahony S (2002) Quantitation of intraepithelial lymphocytes in human duodenum: what is normal? J Clin Pathol 55:393–394
Cuvelier C, Demetter P, Mielants H, Veys EM, De Vos M (2001) Interpretation of ileal biopsies: morphologic features in normal and diseased mucosa. Histopathology 38:1–12
Stange EF, Travis SP, Vermeire S, Beglinger C, Kupcinkas L, Geboes K, Barakauskiene A, Villanacci V, Von Herbay A, Warren BF, Gasche C, Tilg H, Schreiber SW, Scholmerich J, Rinisch W (2006) European Crohn’s and Colitis Organisation. European evidence based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis. Gut 55(Suppl 1):i1–i15
Gustavsson S, Weiland LH, Kelly KA (1987) Relationship of backwash ileitis to ileal pouchitis after ileal pouch-anal anastomosis. Dis Col Rectum 30:25–28
Warren BF, Sheperd NA (2001) What are the controversies in histopathological diagnosis? In: DP, Warrren BF, Mortensen NJ (eds) Challenges in inflammatory bowel disease. Blackwell Science, London
Moskowitz RL, Sheperd NA, Nicholls RJ (1986) An assessment of inflammation in the reservoir after restorative proctocolectomy with ileoanal ileal reservoir. Int J Colorectal Dis 1:167–174
Sheperd NA, Hulten L, Tytgat GN, Nicholls RJ, Nasmyth DG, Hill MJ, Fernandez F, Gertner DJ, Rampton DS (1989) Pouchitis. Int J Colorectal Dis 4:205–229
Heuschen UA, Hinz U, Allemeyer EH, Stern J, Lucas M, Autschbach F, Herfarth C, Heuschen C (2001) Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis. Gastroenterology 120:841–847
Sheperd NA, Healey CJ, Warren BF, Richman PI, Thomson WHF, Wilkinson SP (1993) Distribution of mucosal pathology and an assessment of colonic phenotypic change in the pelvic ileal reservoir. Gut 34:101–105
Setti-Carraro P, Talbot IC, Nicholls RJ (1994) Long term appraisal of the histological appearances of the ileal mucosa after restorative proctocolectomy for ulcerative colitis. Gut 35:1721–1727
Talbot IC, Price AB (1987) Biopsy pathology in Colorectal Disease. Chapman and Hall, London
Montgomery EA (2006) Biopsy interpretation of the gastrointestinal tract mucosa. Lippincott Williams & Wilkins, Philadelphia
Green PH, Jabri B (2003) Coeliac disease. Lancet 362:383–391
Ravelli A, Bolognini S, Gambarotti M, Villanacci V (2005) Variability of histologic lesions in relation to biopsy site in gluten-sensitive enteropathy. Am J Gastroenterol 100:177–185
Marsh MN (1990) Grains of truth: evolutionary changes in small intestinal mucosa in response to environmental antigen challenge. Gut 31:111–114
Oberhuber G, Granditsch G, Vogelsang H (1999) The histopathology of coeliac disease: time for a standardized report scheme for pathologists. Eur J Gastroenterol Hepatol 11:1185–1194
Corazza GR, Villanacci V (2005) Coeliac disease. Some considerations on the histological classification. J Clin Pathol 58:573–574
Mahadeva S, Wyatt JI, Howdle PD (2002) Is a raised intraepithelial lymphocyte count with normal duodenal villous architecture clinically relevant? J Clin Pathol 55:424–428
Antonioli DA (2003) Celiac disease: a progress report. Mod Pathol 16:342–346
Kakar S, Nehra V, Murray JA, Dayharsh GA, Burgart LJ (2003) Significance of intraepithelial lymphocytosis in small bowel biopsy samples with normal mucosal architecture. Am J Gastroenterol 98:2027–2033
Jarvinen TT, Kaukinen K, Laurila K, Kyronpalo S, Rasmussen M, Maki M, Korhonen H, Reunala T, Collin P (2003) Intraepithelial lymphocytes in celiac disease. Am J Gastroenterol 98:1332–1337
Rostami K (2003) From microenteropathy to villous atrophy: what is treatable? Dig Liver Dis 35:758–789
Dickey W, Hughes DF (2004) Histology of the terminal ileum in coeliac disease. Scand J Gastroenterol 39:665–667
Hopper AD, Hurlstone DP, Leeds JS, McAlindon ME, Dube AK, Stephenson TJ, Samders DS (2006) The Occurrence of terminal ileal histological abnormalities in patients with coeliac disease. Dig Liver Dis 38(11):820–822
Olesen M, Eriksson S, Bohr J, Jarnerot G, Tysk C (2004) Lymphocytic colitis: a retrospective clinical study of 199 Swedish patients. Gut 53:536–541
Villanacci V, Bassotti G, Liserre B, Lanzini A, Lanzarotto F, Genta RM (2006) Helicobacter pylori infection in patients with celiac disease. Am J Gastroenterol 101(8):1880–1885
Greenson JK (ed) (2010) Diagnostic pathology: gastrointestinal, 1st edn. Amirsys Inc, Salt Lake City
Fenoglio C (2008) Preiser gastrointestinal pathology. An atlas and text, 3rd edn. LWW, Philadelphia
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Villanacci, V., Bassotti, G. (2012). The Role of Histology in Small Bowel Diseases. In: Trecca, A. (eds) Ileoscopy. Springer, Milano. https://doi.org/10.1007/978-88-470-2345-1_9
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DOI: https://doi.org/10.1007/978-88-470-2345-1_9
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