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Neoadjuvant Treatment

  • Felice Pasini
  • Anna Paola Fraccon
  • Giovanni de Manzoni
Part of the Updates in Surgery book series (UPDATESSURG)

Abstract

To date, the benefits and risks of neoadjuvant chemoradiotherapy (CRT) in esophageal cancer have been investigated in randomized phase III clinical trials, phase II trials, and retrospective studies [1, 2, 3]. Randomized clinical trials [4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15] compared neoadjuvant CRT with surgery alone and, although most of them demonstrated higher survival rates in the combination arm, overall survival (OS) and disease-free survival (DFS) were statistically improved in only four [4, 5, 6, 7] and two trials [8, 9], respectively (Table 12.1).

Keywords

Overall Survival Esophageal Cancer Intergroup Trial Medical Research Council Trial Cross Trial 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Felice Pasini
    • 1
  • Anna Paola Fraccon
  • Giovanni de Manzoni
  1. 1.Dept. of Medical Oncology“Santa Maria della Misericordia” HospitalRovigoItaly

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