Neoadjuvant Treatment

  • Felice Pasini
  • Anna Paola Fraccon
  • Giovanni de Manzoni
Part of the Updates in Surgery book series (UPDATESSURG)


To date, the benefits and risks of neoadjuvant chemoradiotherapy (CRT) in esophageal cancer have been investigated in randomized phase III clinical trials, phase II trials, and retrospective studies [1, 2, 3]. Randomized clinical trials [4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15] compared neoadjuvant CRT with surgery alone and, although most of them demonstrated higher survival rates in the combination arm, overall survival (OS) and disease-free survival (DFS) were statistically improved in only four [4, 5, 6, 7] and two trials [8, 9], respectively (Table 12.1).


Overall Survival Esophageal Cancer Intergroup Trial Medical Research Council Trial Cross Trial 
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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Felice Pasini
    • 1
  • Anna Paola Fraccon
  • Giovanni de Manzoni
  1. 1.Dept. of Medical Oncology“Santa Maria della Misericordia” HospitalRovigoItaly

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