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Multimodal Treatment: Early and Long-term Results and Recurrences

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Treatment of Esophageal and Hypopharyngeal Squamous Cell Carcinoma

Part of the book series: Updates in Surgery ((UPDATESSURG))

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Abstract

In the past, the treatment of choice for hypopharyngeal and cervical squamous cell carcinoma (SCC) was radiotherapy alone, administered over large fields and using what have now become obsolete techniques. The early and late outcomes and quality of life of these patients were disappointing, since many often required additional palliative surgical treatment to control dysphagia or complications associated with radiotherapy (RT). A major advance occurred in 1960, with the adoption of pharyngolaryngoesophagectomy (PLE), with or without adjuvant RT, as the standard surgical approach for cervical esophageal carcinoma (CEC) [1]. However, despite significant improvements over the following decades, PLE has a high morbidity (49%) and mortality (9%), and the quality of life is compromised by “en bloc” laryngectomy [2].

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Authors and Affiliations

  1. Radiation Oncology Unit, Borgo Trento Hospital, Verona, Italy

    Antonio Grandinetti

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  1. Antonio Grandinetti
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Editors and Affiliations

  1. Dept. of Surgery Upper G.I. Surgery Division, University of Verona, Verona, Italy

    Giovanni de Manzoni

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Grandinetti, A. (2012). Multimodal Treatment: Early and Long-term Results and Recurrences. In: de Manzoni, G. (eds) Treatment of Esophageal and Hypopharyngeal Squamous Cell Carcinoma. Updates in Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-2330-7_11

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  • DOI: https://doi.org/10.1007/978-88-470-2330-7_11

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2329-1

  • Online ISBN: 978-88-470-2330-7

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