Multimodal Treatment: Early and Long-term Results and Recurrences

  • Antonio Grandinetti
Part of the Updates in Surgery book series (UPDATESSURG)


In the past, the treatment of choice for hypopharyngeal and cervical squamous cell carcinoma (SCC) was radiotherapy alone, administered over large fields and using what have now become obsolete techniques. The early and late outcomes and quality of life of these patients were disappointing, since many often required additional palliative surgical treatment to control dysphagia or complications associated with radiotherapy (RT). A major advance occurred in 1960, with the adoption of pharyngolaryngoesophagectomy (PLE), with or without adjuvant RT, as the standard surgical approach for cervical esophageal carcinoma (CEC) [1]. However, despite significant improvements over the following decades, PLE has a high morbidity (49%) and mortality (9%), and the quality of life is compromised by “en bloc” laryngectomy [2].


Intensity Modulate Radiation Therapy Gross Tumor Volume Cervical Squamous Cell Carcinoma Intensity Modulate Radiation Therapy Plan Larynx Preservation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Antonio Grandinetti
    • 1
  1. 1.Radiation Oncology UnitBorgo Trento HospitalVeronaItaly

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