Epidemiology of Esophageal and Hypopharyngeal Squamous Cell Carcinoma

  • Giuseppe Verlato
  • Giovanni de Manzoni
Part of the Updates in Surgery book series (UPDATESSURG)


Esophageal cancer is the eighth most common cancer worldwide, with 481,000 new cases (3.8% all newly diagnosed cancers) estimated in 2008, and the sixth most common cause of death from cancer, with 406,000 deaths (5.4% of all cancer deaths) [1]. These figures encompass both of the major histological types, squamous cell carcinoma (SCC) and adenocarcinoma (AC).


Squamous Cell Carcinoma Esophageal Cancer Esophageal Squamous Cell Carcinoma Smokeless Tobacco Hypopharyngeal Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Ferlay J, Shin HR, Bray F et al (2010) GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [Internet]. International Agency for Research on Cancer, Lyon, France. Available from: http://globocan.iarc.frGoogle Scholar
  2. 2.
    Mousavi SM, Brandt A, Sundquist J, Hemminki K (2011) Esophageal cancer risk among immigrants in Sweden. Eur J Cancer Prev 20:71–76PubMedCrossRefGoogle Scholar
  3. 3.
    Gholipour C, Shalchi RA, Abbasi M (2008) A histopathological study of esophageal cancer on the western side of the Caspian littoral from 1994 to 2003. Dis Esophagus 21: 322–327PubMedCrossRefGoogle Scholar
  4. 4.
    La Vecchia C, Bosetti C, Lucchini F et al (2010) Cancer mortality in Europe, 2000–2004, and an overview of trends since 1975. Ann Oncol 21:1323–1360PubMedCrossRefGoogle Scholar
  5. 5.
    Corley DA, Buffler PA (2001) Oesophageal and gastric cardia adenocarcinomas: Analysis of regional variation using the Cancer Incidence in Five Continents database. Int J Epidemiol 30:1415–1425PubMedCrossRefGoogle Scholar
  6. 6.
    AIRT Working Group (2006) Italian cancer figures — Report 2006: Incidence, mortality and estimates. Epidemiologia & Prevenzione 30(1): Supplemento 2Google Scholar
  7. 7.
    Trivers KF, Sabatino SA, Stewart SL (2008) Trends in esophageal cancer incidence by histology, United States, 1998-2003. Int J Cancer 123:1422–1428PubMedCrossRefGoogle Scholar
  8. 8.
    Rozen P, Liphshitz I, Barchana M (2009) The changing epidemiology of upper gastrointestinal cancers in Israel: clinical and screening implications. Eur J Cancer Prev 18:191–198PubMedCrossRefGoogle Scholar
  9. 9.
    Vizcaino AP, Moreno V, Lambert R, Parkin DM (2002) Time trends incidence of both major histologic types of esophageal carcinomas in selected countries, 1973–1995. Int J Cancer 99: 860–868PubMedCrossRefGoogle Scholar
  10. 10.
    Cook MB, Dawsey SM, Freedman ND et al (2009) Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev 18:1174–1182PubMedCentralPubMedCrossRefGoogle Scholar
  11. 11.
    Nordenstedt H, El-Serag H (2011) The influence of age, sex, and race on the incidence of esophageal cancer in the United States (1992–2006). Scand J Gastroenterol 46:597–602PubMedCrossRefGoogle Scholar
  12. 12.
    Kubo A, Corley DA (2004) Marked multi-ethnic variation of esophageal and gastric cardia carcinomas within the United States. Am J Gastroenterol 99:582–588PubMedCrossRefGoogle Scholar
  13. 13.
    Blot WJ, Devesa SS, McLaughlin JK, Fraumeni JR JF (1994) Oral and pharyngeal cancers. Cancer Surv 19/20:23–42Google Scholar
  14. 14.
    Ligier K, Belot A, Launoy G et al, for Network Francim (2011) Descriptive epidemiology of upper aerodigestive tract cancers in France: Incidence over 1980–2005 and projection to 2010. Oral Oncol 47:302–307PubMedCrossRefGoogle Scholar
  15. 15.
    Mousavi SM, Sundquist J, Hemminki K (2010) Nasopharyngeal and hypopharyngeal carcinoma risk among immigrants in Sweden. Int J Cancer 127:2888–2892PubMedCrossRefGoogle Scholar
  16. 16.
    Su YY, Fang FM, Chuang HC et al (2010) Detection of metachronous esophageal squamous carcinoma in patients with head and neck cancer with use of transnasal esophagoscopy. Head Neck 32:780–785PubMedGoogle Scholar
  17. 17.
    Wang WL, Lee CT, Lee YC et al (2011) Risk factors for developing synchronous esophageal neoplasia in patients with head and neck cancer. Head Neck 33:77–81PubMedCrossRefGoogle Scholar
  18. 18.
    Berrino F, De Angelis R, Sant M et al (2007) Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995–1999: results of the EUROCARE-4 study. Lancet Oncol 8:773–783PubMedCrossRefGoogle Scholar
  19. 19.
    Jemal A, Siegel R, Ward E et al (2006) Cancer statistics, 2006. CA Cancer J Clin 56:106–130PubMedCrossRefGoogle Scholar
  20. 20.
    Crocetti E, Capocaccia R, Casella C et al (2004) Cancer trends in Italy: figures from the Cancer Registries (1986–1997). Epidemiologia & Prevenzione 28:S1–S112Google Scholar
  21. 21.
    AIRTUM Working Group (2009) New incidence and mortality data: 2003–2005. Epidemiologia & Prevenzione 33(1–2): Supplemento 2Google Scholar
  22. 22.
    Wahlberg PCG, Andersson KE, Bjorklund AT, Moller TR (1998) Carcinoma of the hypopharynx: Analysis of incidence and survival in Sweden over a 30-year period. Head Neck 20:714–719PubMedCrossRefGoogle Scholar
  23. 23.
    Falk GW (2009) Risk factors for esophageal cancer development. Surg Oncol Clin N Am 18:469–485PubMedCrossRefGoogle Scholar
  24. 24.
    Hongo M, Nagasaki Y, Shoji T (2009) Epidemiology of esophageal cancer: Orient to Occident. Effects of chronology, geography and ethnicity. J Gastroenterol Hepatol 24:729–735PubMedCrossRefGoogle Scholar
  25. 25.
    Lubin JH, Purdue M, Kelsey K et al (2009) Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies. Am J Epidemiol 170:937–947PubMedCentralPubMedCrossRefGoogle Scholar
  26. 26.
    Fan Y, Yuan J-M, Wang R et al (2008) Alcohol, tobacco, and diet in relation to esophageal cancer: the Shangai cohort study. Nutr Cancer 60:354–363PubMedCentralPubMedCrossRefGoogle Scholar
  27. 27.
    Lee YCA, Marron M, Benhamou S et al (2009) Active and involuntary tobacco smoking and upper aerodigestive tract cancer risks in a multicenter case-control study. Cancer Epidemiol Biomarkers Prev 18:3353–3361PubMedCentralPubMedCrossRefGoogle Scholar
  28. 28.
    Anantharaman D, Marron M, Lagiou P et al (2011) Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer. Oral oncology 47:725–731PubMedCrossRefGoogle Scholar
  29. 29.
    Islami F, Malekshah AF, Kimiagar M et al (2009) Patterns of food and nutrient consumption in Northern Iran, a high-risk area for esophageal cancer. Nutr Cancer 61:475–483PubMedCentralPubMedCrossRefGoogle Scholar
  30. 30.
    Aune D, Deneo-Pellegrini H, Ronco AL et al (2011) Dietary folate intake and the risk of 11 types of cancer: a case-control study in Uruguay. Ann Oncol 22:444–451PubMedCrossRefGoogle Scholar
  31. 31.
    Brown LM, Hoover R, Silverman D et al (2001) Excess incidence of squamous cell esophageal cancer among US black men: role of social class and other risk factors. Am J Epidemiol 153:114–122PubMedCrossRefGoogle Scholar
  32. 32.
    Conway DI, McKinney PA, McMahon AD et al (2010) Socioeconomic factors associated with risk of upper aerodigestive tract cancer in Europe. Eur J Cancer 46:588–598PubMedCrossRefGoogle Scholar
  33. 33.
    Hoffmann M, Gorogh T, Gottschlich S et al (2005) Human papillomaviruses in head and neck cancer: 8 year-survival-analysis of 73 patients. Cancer Letters 218:199–206PubMedCrossRefGoogle Scholar
  34. 34.
    Corley DA, Kubo A, Zhao W (2008) bdominal obesity and the risk of esophageal and gastric cardia carcinomas. Cancer Epidemiol Biomarkers Prev 17:352–358PubMedCentralPubMedCrossRefGoogle Scholar
  35. 35.
    Crocetti E, AIRTUM Working Group (2009) Per quali tumori l’incidenza sta cambiando più rapidamente? Epidemiol Prev 33:78PubMedGoogle Scholar
  36. 36.
    Centro Nazionale di Epidemiologia, Sorveglianza e Promozione della Salute, Istituto Superiore di Sanità. La mortalità per causa in Italia: 1980-2002.
  37. 37.
    Devesa SS, Blot WJ, Fraumeni JF Jr (1998) Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 83:2049–2053PubMedCrossRefGoogle Scholar
  38. 38.
    Steevens J, Botterweck AAM, Dirx MJM et al (2010) Trends in incidence of oesophageal and stomach cancer subtypes in Europe. Eur J Gastroenterol Hepatol 22:669–678PubMedGoogle Scholar
  39. 39.
    Huisman M, Kunst AE, Mackenbach JP (2005) Educational inequalities in smoking among men and women aged 16 years and older in 11 European countries. Tob Control 14:106–113PubMedCentralPubMedCrossRefGoogle Scholar
  40. 40.
    World Health Organization Statistical Information System. Health topics. Alcohol drinking

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Giuseppe Verlato
    • 1
  • Giovanni de Manzoni
  1. 1.Unit of Epidemiology and Medical StatisticsUniversity of VeronaVeronaItaly

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