Skip to main content

Surgical Treatment of Liver Metastases from Gastric Cancer

  • Chapter
Surgery in the Multimodal Management of Gastric Cancer

Abstract

After a brief description of the clinical characteristics of hepatic metastases from gastric cancer and their different clinical settings, we discuss the natural evolution of the disease, focusing on the extremely poor prognosis of these patients. Through a complete review of the literature, the chapter provides detailed insight into the different therapeutic options, discussing their indications, patient selection criteria, and results. We argue that a correct therapeutic approach can offer to a relatively large percentage of patients (≈ 40%) an unexpected 20–40% 5-year survival rate. Our main purpose is to convey the cultural basis that will induce the reader to reconsider the largely predominating passive attitude toward these patients by acknowledging the opportunity to offer better and longer survival to a selected subgroup.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Dicken BJ, Bigam DL, Cass C et al (2005) Gastric adenocarcinoma. Review and considerations for future directions. Ann Surg 241:27–39

    PubMed  Google Scholar 

  2. D’Angelica M, Gonen M, Brennan MF et al (2004) Patterns of initial recurrence in completely resected gastric adenocarcinoma. Ann Surg 240:808–816

    Article  PubMed  Google Scholar 

  3. Tiberio GAM, Coniglio A, Marchet A et al (2009) Metachronous hepatic metastases from gastric carcinoma: a multicentric survey. EJSO 35:486–491

    Article  PubMed  CAS  Google Scholar 

  4. Marrelli D, Roviello F, De Stefano A et al (2004) Risk factors for liver metastases after curative surgical procedures for gastric cancer: a prospective study of 208 patients treated with surgical resection. J Am Coll Surg 198:51–58

    Article  PubMed  Google Scholar 

  5. Japanese Gastric Cancer association (1998) Japanese classification of gastric carcinoma. 2nd English edition. Gastric Cancer 1:10–24

    Article  PubMed  Google Scholar 

  6. Cocconi G, Carlini P, Gamboni A et al (2003) Cisplatin, epirubicin, leucovorin and 5-fluorourail (PELF) is more active than 5-fluorouracil, doxorubicin and methotrexate (FAMTX) in advanced gastric carcinoma. Ann Oncol 14:1258–1263

    Article  PubMed  CAS  Google Scholar 

  7. Lee J, Kang WK, Kwon JM et al (2007) Phase II trial of irinotecan plus oxaliplatin and 5-fluorouracil/leucovorin in patients with untreated metastatic gastric adenocarcinoma. Ann Oncol 18:88–92

    Article  PubMed  CAS  Google Scholar 

  8. Cao W, Yang W, Lou G et al (2009) Phase II trial of infusional fluorouracil, leucovorin, oxaliplatin and irinotecan (FOLFOXIRI) as first-line treatment for advanced gastric cancer. Anticancer Drugs 20:287–293

    Article  PubMed  CAS  Google Scholar 

  9. Yoshida M, Ohtsu A, Boku N et al (2004) Long-term survival and prognostic factors in patients with metastatic gastric cancers treated with chemotherapy in the Japan Clinical Oncology Group (JCOG) study. JJCO 34:654–659

    PubMed  Google Scholar 

  10. Okano K, Maeba T, Ishimura K et al (2002) Hepatic resection for metastatic tumors from gastric cancer. Ann Surg 235:86–91

    Article  PubMed  Google Scholar 

  11. Ambiru S, Miyazaki M, Ito H et al (2001) Benefits and limits of hepatic resection for gastric metastases. Am J Surg 181:279–283

    Article  PubMed  CAS  Google Scholar 

  12. Kerkar SP, Kemp CD, Avital I (2010) Liver resections in metastatic gastric cancer. HPB 12:589–596

    Article  PubMed  Google Scholar 

  13. Chiche L, Ducreux M, Lebreton G et al (2005) Métastases hépatiques des cancers de l’estomac. In: Adam R, Chiche L, eds. Chirurgie des métastases hépatiques de cancers non colorectaux non endocrine. Monographies de l’association Française de Chirurgie. Arnette, Paris pp 45–59

    Google Scholar 

  14. Ochiai T, Sasako M, Mizuno S et al (1994) Hepatic resection for metastatic tumours from gastric cancer: analysis of prognostic factors. Br J Surg 81:1175–1178

    Article  PubMed  CAS  Google Scholar 

  15. Miyazaki M, Itoh H, Nakagawa K et al (1997) Hepatic resection of liver metastases from gastric carcinoma. Am J Gastroenterol 92:490–493

    PubMed  CAS  Google Scholar 

  16. Fujii K, Fujioka S, Kato K et al (2001) Resection of liver metastasis from gastric adenocarcinoma. Hepatogastroenterology 48:368–371

    PubMed  CAS  Google Scholar 

  17. Imamura H, Matsuyama Y, Shimada R et al (2001) A study of factors influencing prognosis after resection of hepatic metastases from colorectal and gastric carcinoma. Am J Gastroenterol 96:3178–3184

    Article  PubMed  CAS  Google Scholar 

  18. Zacherl J, Zacherl M, Scheuba C et al (2002) Analysis of hepatic resection of metastasis originating from gastric adenocarcinoma. J Gastrointest Surg 6:682–689

    Article  PubMed  Google Scholar 

  19. Saiura A, Umekita N, Inoue S et al (2002) Clinicopathological features and outcome of hepatic resection for liver metastasis from gastric cancer. Hepatogastroenterology 49:1062–1065

    PubMed  Google Scholar 

  20. Shirabe K, Shimada M, Matsumata T et al (2003) Analysis of the prognostic factors for liver metastasis of gastric cancer after hepatic resection: a multi-institutional study of the indications for resection. Hepatogastroenterology 50:1560–1563

    PubMed  Google Scholar 

  21. Roh HR, Suh KS, Lee HJ et al (2005) Outcome of hepatic resection for metastatic gastric cancer. Am Surg 71:95–99

    PubMed  Google Scholar 

  22. Sakamoto Y, Sano T, Shimada K et al (2007) Favorable indications for hepatectomy in patients with liver metastasis from gastric cancer. J Surg Oncol 95:534–539

    Article  PubMed  Google Scholar 

  23. Koga R, Junji Y, Shigekazu O et al (2007) Liver resection for metastatic gastric cancer: experience with 42 patients including eight long-term survivors. JJCO 37:836–842

    PubMed  Google Scholar 

  24. Tsujimoto H, Ichikura T, Ono S et al (2010) Outcomes for patients following hepatic resection of metastatic tumors from gastric cancer. Hepatol Int 4:406–413

    Article  PubMed  Google Scholar 

  25. Cheon SH, Rha SY, Jeung H-C et al (2008) Survival benefit of combined curative resection of the stomach (D2 resection) and liver in gastric cancer patients with liver metastases. Ann Onc 19:1146–1153

    Article  CAS  Google Scholar 

  26. Makino H, Kunisaki C, Izumisawa Y et al (2010) Indication for hepatic resection in the treatment of liver metastasis from gastric cancer. Anticanc Res 30:2367–2376

    Google Scholar 

  27. Ueda K, Iwahashi M, Nakamori M et al (2009) Analysis of the prognostic factors and evaluation of surgical treatment for synchronous liver metastases from gastric cancer. Langenbecks Arch Surg 394:647–653

    Article  PubMed  Google Scholar 

  28. Adam R, Chiche L, Aloia T et al (2006) Hepatic resection for noncolorectal nonendocrine liver metastases. Ann Surg 244:524–535

    Article  PubMed  Google Scholar 

  29. Hwang S-E, Yang D-H, Kim C-Y (2009) Prognostic factors for survival in patients with hepatic recurrence after curative resection of gastric cancer. World J Surg 33:1468–1472

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Italia

About this chapter

Cite this chapter

Tiberio, G.A.M., Coniglio, A., Baiocchi, G.L., Giulini, S.M. (2012). Surgical Treatment of Liver Metastases from Gastric Cancer. In: de Manzoni, G., Roviello, F., Siquini, W. (eds) Surgery in the Multimodal Management of Gastric Cancer. Springer, Milano. https://doi.org/10.1007/978-88-470-2318-5_14

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-2318-5_14

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2317-8

  • Online ISBN: 978-88-470-2318-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics