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Pharmacological Combinations and Techniques in the Acute and Chronic Benign Pain

  • F. Ramajoli
  • L. Carnevale
  • S. Malfatti
Conference paper

Abstract

Pain is defined as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage” [31].

Keywords

Dorsal Horn Epidural Morphine Epidural Injection Intrathecal Morphine Labor Analgesia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Abboud TK, Zhu J et al (1996) The efficacy of intrathecal injection of sufentanil using a microspinal catheter for labor analgesia. Acta Anaesth Scand 40: 210–215PubMedCrossRefGoogle Scholar
  2. 2.
    Abouleish E, Rawal N et al (1991) Intrathecal morphine 0.2 mg versus epidural bupivacaine 0.125% or their combination: effects on parturients. Anesthesiology 74: 711–716PubMedCrossRefGoogle Scholar
  3. 3.
    Adriaensen H, Gybels J et al (1983) Response properties of thin myelinated (AÔ) fibers in human skin nerves. J Neurophysiol 49: 111–122PubMedGoogle Scholar
  4. 4.
    Aghajanian GK, Vandur Maelen CP (1982) α2 adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo. Science 215: 1394–1396PubMedCrossRefGoogle Scholar
  5. 5.
    Atweh SF, Kuhar MJ (1977) Autoradiographic localization of opiate receptors in rat brain, spinal cord and lower medulla. Brain Res 124: 53–67PubMedCrossRefGoogle Scholar
  6. 6.
    Ben-David B, Baune-Goldstein U et al (1996) Is preoperative ketorolac a useful adjunct to regional anesthesia for inguinal herniorrhaphy? Acta Anaesth Scand 40: 358–363PubMedCrossRefGoogle Scholar
  7. 7.
    Benzon HT (1986) Epidural steroid injections for low back-pain and lumbosacral radiculopathy. Pain 24: 277–295PubMedCrossRefGoogle Scholar
  8. 8.
    Bessou P, Perl ER (1969) Responses of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol 32: 1025–1043PubMedGoogle Scholar
  9. 9.
    Bousquet P, Schwartz J (1983) α-Adrenergic drugs. Pharmacological tools for the study of the central vasomotor control. Biochem Pharmacol 32: 1459–1465PubMedCrossRefGoogle Scholar
  10. 10.
    Broekema AA, Kuizenga K, Hennis PJ (1996) Does epidural sufentanil provide effective analgesia per- and postoperatively for abdominal aortic surgery? Acta Anaesth Scand 40: 20–25PubMedCrossRefGoogle Scholar
  11. 11.
    Buccafusco JJ, Aronstam JJ (1986) Clonidine protection from the toxicity of soman, an organophosphate acetylcolinesterase inhibitor in the mouse. J Pharmacol Exp Ther 239: 43–47PubMedGoogle Scholar
  12. 12.
    Butterworth JF, Strichartz GR (1990) Molecular mechanisms of local anesthesia: a review. Anestesiology 72: 711–734CrossRefGoogle Scholar
  13. 13.
    Camann WR, Minzter BH et al (1993) Intrathecal sufentanil for labor analgesia: effects of added epinephrine. Anesthesiology 78: 870–874PubMedCrossRefGoogle Scholar
  14. 14.
    Childers SR (1991) Opioid receptor coupled second messanger system. Life Sci 48: 1991–2003PubMedCrossRefGoogle Scholar
  15. 15.
    Cousins M.J. (1994) Mechanisms of neuropathic pain: implications for clinical treatment. In: Nineteenth Annual Meeting ASRA, Chicago, April 7–10, pp 226–275Google Scholar
  16. 16.
    Dausse JP, Cardot A, Meyer P (1983) Specific binding of 3H-guanfacine to a2 adrenoceptors in rat brain. Comparison with Clonidine. J Pharmacol 14: 35–46PubMedGoogle Scholar
  17. 17.
    Devor M, Govrin-Lippman R, Raber P (1985) Corticosteroids suppress ectopic neural discharges originating in experimental neuromas. Pain 22: 127–137PubMedCrossRefGoogle Scholar
  18. 18.
    Dickinson AH (1991) Mechanism of the analgesic actions of opiates and opioid. Brit Med Bull 47: 690–702Google Scholar
  19. 19.
    Franks NP, Lieb WR (1988) Volatile general anaesthetics activate a novel neuronal K+ current. Nature 333: 662–664PubMedCrossRefGoogle Scholar
  20. 20.
    Glynn C, Dawson D, Sanders R (1988) A double blind comparison between epidural morphine and epidural Clonidine in patients with chronic non cancer-pain. Pain 34: 123–128PubMedCrossRefGoogle Scholar
  21. 21.
    Goebert HW et al (1960) Sciatica: treatment with epidural injections of procaine and hydrocortisone. Cleve Clin Q 27: 191–197PubMedGoogle Scholar
  22. 22.
    Hammonds WD (1989) Epidural steroids. In: ASRA News, pp 2Google Scholar
  23. 23.
    Hescheler J, Rosenthal W, Trautwein W et al (1987) The GTP-binding protein, G0, regulates neuronal calcium channels. Nature 325: 445–447PubMedCrossRefGoogle Scholar
  24. 24.
    Honet JE, Arkoosh WA et al (1992) Comparison among intrathecal fentanyl, meperidine and sufentanil for labor analgesia. Anesth Analg 75: 734–739PubMedCrossRefGoogle Scholar
  25. 25.
    Lipscombe D, Kongsamut S, Tsien RW (1989) α-adrenergic inhibition of sympathetic neurotrasmitter release mediated by modulation of N-type calcium channel gating. Nature 340: 639–642PubMedCrossRefGoogle Scholar
  26. 26.
    Liu S, Kopacz DJ et al (1995) Quantitative assessment of differential sensory nerve block after lidocaine spinal anesthesia. Anesthesiology 82: 60–63PubMedCrossRefGoogle Scholar
  27. 27.
    Maze M, Tranquilli W (1991) Alpha-2-adrenoreceptor agonists: defining the role in clinical anesthesia. Anesthesiology 74: 581–605PubMedCrossRefGoogle Scholar
  28. 28.
    Mc Carron RF, Weempee MW et al (1987) The inflammatory effect of nucleous pulposus. A possible element in the pathogenesis of low-back pain. Spine 12: 760–764CrossRefGoogle Scholar
  29. 29.
    Mc Fadzean I (1988) The ionic mechanisms underlying opioid actions. Neuropeptides 11: 173–180CrossRefGoogle Scholar
  30. 30.
    Meller ST, Gebhart GF (1993) Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 52: 127–136PubMedCrossRefGoogle Scholar
  31. 31.
    Merskey H (1986) Classification of chronic pain. Descriptions of chronic pain syndromes and definitions of pain terms. Pain [Suppl] 3: S11Google Scholar
  32. 32.
    Ming Li Y, Wingrove DE et al (1995) Local anesthetics inhibit substance P binding and evoke increases in intracellular Ca++. Anesthesiology 82: 166–173CrossRefGoogle Scholar
  33. 33.
    Murray CW, Cowan A, Larson AA (1991) Neurokinin and NMDA antagonists (but not kainic acid antagonists) are antinociceptive in the mouse formalin model. Pain 44: 179–185PubMedCrossRefGoogle Scholar
  34. 34.
    Myers RR (1995) The pathogenesis of neuropathic pain. Reg Anesth 20(3): 173–184PubMedGoogle Scholar
  35. 35.
    Nicol GD, Klingberg DK, Vasko MR (1992) Prostaglandin E2 increases calcium conductance and stimulates release of substance P in avian sensory neurons. J Neurosci 12: 1917–1927PubMedGoogle Scholar
  36. 36.
    Omote K, Kitahata CM, Collins JG et al (1991) Interactions between opiate subtype and alfa-2-adrenergic agonists in suppression of noxiously evoked activity of WDR neurons in the spinal dorsal horn. Anesthesiology 74: 737–743PubMedCrossRefGoogle Scholar
  37. 37.
    Ostuka M, Yoshiola K (1993) Neurotransmitter functions of mammalian tachykinins. Physiol Rev 73:229–308Google Scholar
  38. 38.
    Owen H, Plummer JL et al (1989) Variables of patient-controlled analgesia: 1 — Bolus size. Anaesthesia 44: 7–10PubMedCrossRefGoogle Scholar
  39. 39.
    Owen H, Szekely SM et al (1989) Variables of patient-controlled-analgesia: 2 — Concurrent infusion. Anaesthesia 44: 11–13PubMedCrossRefGoogle Scholar
  40. 40.
    Paul D, Bodnar RJ et al (1989) Different µ receptor subtypes mediate spinal and supraspinal analgesia in mice. Eur J Pharmacol 168: 307–314PubMedCrossRefGoogle Scholar
  41. 41.
    Peterson J, Gordh TE Jr, Hartvig P et al (1986) A double blind trial of the analgesic effect of i.v. physostigmine on postoperative pain. Acta Anaesthesiol Scand 30: 283–288CrossRefGoogle Scholar
  42. 42.
    Pountain GD, Keegan AL, Jayson MIV (1987) Impaired fibrinolytic activity in defined chronic back pain syndromes. Spine 12: 83–86PubMedCrossRefGoogle Scholar
  43. 43.
    Power I, Brown DT, Wildsmith JAW (1991) The effect of fentanyl, meperidine and diamorphine on nerve conduction in vitro. Reg Anesth 16: 204–208PubMedGoogle Scholar
  44. 44.
    Probst A, Cortes R, Palacios JM (1985) Distribution of α2-adrenergic receptors in the human brain stem: an autoradiographic study using [3H]p-aminoclonidine. Eur J Pharmacol 106: 477–488CrossRefGoogle Scholar
  45. 45.
    Rauck RL, Eisenach JC et al (1993) Epidural Clonidine treatment for refractory reflex sympathetic dystrophy. Anesthesiology 79: 1163–1169PubMedCrossRefGoogle Scholar
  46. 46.
    Ray PP, Neumann MM (1996) Facet Blocks. In: Pain Medicine, Mosby Ed, pp 266–271Google Scholar
  47. 47.
    Rocco AG, Frank E et al (1989) Epidural steroids, epidural morphine and epidural steroid combined with morphine in the treatment of post-laminectomy syndrome. Pain 36: 297–303PubMedCrossRefGoogle Scholar
  48. 48.
    Rostaing S, Bonnet F et al (1991) Effect of epidural Clonidine on analgesia and pharmacokinetics of epidural fentanyl in postoperative patients. Anesthesiology 75: 420–425PubMedCrossRefGoogle Scholar
  49. 49.
    Salomäki E, Kokki H et al (1996) Introducing epidural fentanyl for on-ward pain relief after major surgery. Acta Anaesth Scand 40: 704–709PubMedCrossRefGoogle Scholar
  50. 50.
    Scott DA, Charnley D (1995) Epidural ropivacaine infusion for postoperative analgesia following major lower abdominal surgery — A dose finding study. Anesth Analg 81: 982–986PubMedGoogle Scholar
  51. 51.
    Simon DL, Kunz RD et al (1989) Allergic or Pseudoallergic reaction following epidural steroid deposition and skin testing. Reg Anesth vol 14, n 5: 253–255PubMedGoogle Scholar
  52. 52.
    Simon LS, Mills JA (1980) Nonsteroidal antinflammatory drugs. N Engl J Med 302: 1237–1243PubMedCrossRefGoogle Scholar
  53. 53.
    Spaulding TC, Fielding S, Venafro JJ et al (1979) Antinociceptive activity of Clonidine and its potentiation of morphine analgesia. Eur J Pharmacol 58:19–25PubMedCrossRefGoogle Scholar
  54. 54.
    Stein C, Millan M et al (1989) Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of µ, δ and K receptors. J Pharmacol Exp Ther 248:1269–1275PubMedGoogle Scholar
  55. 55.
    Taiwo YO, Levine JD (1991) K and δ opioids block sympathetically dependent hyperalgesia. J Neurosci 11:928–932PubMedGoogle Scholar
  56. 56.
    Taiwo YO, Levine JD (1988) Prostaglandins inhibit endogenous control mechanisms by blocking transmission at spinal noradrenergic synapses. J Neurosci 8:1346–1349PubMedGoogle Scholar
  57. 57.
    Tejwani GA, Rattan AK, Mc Donald JS (1992) Role of spinal opioid receptors in the antinociceptive interactions between intrathecal morphine and bupivacaine. Anesth Analg 74: 726–734PubMedCrossRefGoogle Scholar
  58. 58.
    Unnerstall JR, Kopajtic TA, Kuhar MJ (1984) Distribution of α2 agonist binding sites in the rat and human central nervous system: analysis of some functional, anatomic correlates of the pharmacologic effects of Clonidine and related adrenergic agents. Brain Res Rev 77:69–101CrossRefGoogle Scholar
  59. 59.
    Voeikow VV, Lefkowitz RJ (1977) Effects of local anesthetics on guanyl nucleotide modulation of the catecholamine-sensitive adenylate cyclase system and β-adrenergic receptors. Biochim Biophys Acta 629:266–281CrossRefGoogle Scholar
  60. 60.
    Watts RW, Silagy CA (1995) A meta-analysis on the efficacy of epidural corticosteroids in the treatment of sciatica. Anaesth Intens Care 23:564–569Google Scholar
  61. 61.
    Wilder Smith CH, Oliver HG et al (1994) Epidural droperidol reduces the side effects and duration of analgesia of epidural sufentanil. Anesth Analg 79:98–104Google Scholar
  62. 62.
    Wyss E, Karp P (1990) Effects of intramuscular or local Clonidine for prolungation of brachial plexus block with lidocaine. Anesthesiology 73:A821CrossRefGoogle Scholar
  63. 63.
    Yamamoto T, Yaksh TL (1992) Comparison of the antinociceptive effects of pre and post treatment with intrathecal morphine and MK801, an NMDA antagonist on the formalin test in rat. Anesthesiology 77:757–763PubMedCrossRefGoogle Scholar
  64. 64.
    Yamamoto T, Yaksh TL (1991) Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP, 96.345: Antinociception in the absence of motor dysfunction. Life Sci 49: 1955–1963PubMedCrossRefGoogle Scholar
  65. 65.
    Yee JP, Bradley R et al (1986) A comparison of analgesic efficacy of intramuscolar ketorolac tromethamine and meperidine in postoperative pain. Clin Pharmacol Ther 39:237–241Google Scholar
  66. 66.
    Yee JP, Koshiver JE et al (1986) Comparison of intramuscolar ketorolac tromethamine and morphine sulfate for analgesia of pain after major surgery. Pharmacotherapy 6:253–261PubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 1997

Authors and Affiliations

  • F. Ramajoli
  • L. Carnevale
  • S. Malfatti

There are no affiliations available

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