Continuous Filtration of Cerebrospinal Fluid (CSF-Filtration) in Fulminant Bacterial Meningitis — A New Adjuvant Therapeutic Strategy?

  • P. Kalischewski
  • D. Schneider
  • H. J. Kühn
Conference paper


The introduction of antibiotics resulted in a reduced mortality rate in bacterial meningitis which, however, remained stable at 5–30% in the last 40 years, despite the development of new antibiotics [ 1, 10] . In order to influence the outcome in this disease new adjuvant strategies are required.


Glasgow Coma Scale Bacterial Meningitis Subarachnoid Space Pneumococcal Meningitis Chronic Inflammatory Demyelinating Polyneuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Durand ML, Calderwood SB, Weber DJ et al (1993) Acute bacterial meningitis in adults. A review of 493 episodes. N Eng J Med 328:21–28CrossRefGoogle Scholar
  2. 2.
    Ekstedt J (1977) CSF hydrodynamic studies in man. 1. method of constant pressure CSF infusion. J Neurol Neurosurg Psychiatry 40:105–119PubMedCrossRefGoogle Scholar
  3. 3.
    Haas J, Sailler M, Düzel E et al (1995) Liquorfiltration bei multipler Sklerose: eine experimentelle Therapie. Neuropsychiatrie 2:109–111Google Scholar
  4. 4.
    Heusslein R, Rother S, Trömel C et al (1996) CSF-fiiltration: scientific and clinical update. In: Gullo A (ed) Anesthesia, pain, intensive care and emergency medicine. Fogliazza Editore, Trieste, pp 627–638CrossRefGoogle Scholar
  5. 5.
    Pfausler B, Schmutzhard E (1995) CSF-fiiltration bei neuroimmunologischen Erkrankungen (GBS, Miller-Fisher-Syndrom, zerebraler Lupus erythematodes). Neuropsychiatrie 2:102–103Google Scholar
  6. 6.
    Pfausler B, Grubwieser G, Bösch S et al (1995) Cerebrospinal fluid-fiiltration reduces TNF alpha in bacterial meningitis-CSF. Europ J Neurol 2:570–572CrossRefGoogle Scholar
  7. 7.
    Pfister HW, Feiden W, Einhäupl KM (1993) Spectrum of complications during bacterial meningitis in adults. Arch Neurol 50:575–579PubMedCrossRefGoogle Scholar
  8. 8.
    Pfister HW (1993) Akut-entzündliche Erkrankungen des Zentralnervensystems. Akt Neurol 20:83–88CrossRefGoogle Scholar
  9. 9.
    Pöhlau D, Schimrigk S, Andrich J et al (1996) Funktionsverbesserungen durch Liquorfiiltrationen bei Patienten mit sporadischer Amyotropher Lateralsklerose (SALS). In: Treib J, Stoll M, Lindemuth R (eds) Arbeitstagung der Arbeitsgemeinschaft für Neurologische Intensivmedizin (ANIM), Verlag Conrad & Bothner, Zweibrücken, p 67 (abstract)Google Scholar
  10. 10.
    Quagliarello V, Scheld WM (1992) Bacterial meningitis: pathogenesis, pathophysiology and progress. N Engl J Med 327:864–872PubMedCrossRefGoogle Scholar
  11. 11.
    Roos K (1996) Meningitis, 100 Maximes. Arnold London, Sydney, Auckland, pp 95, 100–102Google Scholar
  12. 12.
    Rother S, Knoblauch KD, Kirschfiink M (1995) Filtration von Liquor cerebrospinalis (CSFfiltration): Technisches Konzept und Filtrationseffizienz unter in-vitro-Bedingungen. Neuropsychiatrie 2:82–85Google Scholar
  13. 13.
    Saukkonen K, Sande S, Cioffe C et al (1990) The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis. J Exp Med 171: 439–448PubMedCrossRefGoogle Scholar
  14. 14.
    Schaad UB, Lips U, Gnehm HE et al (1993) Dexamethasone therapy for bacterial meningitis in children. Lancet 342:457–461PubMedCrossRefGoogle Scholar
  15. 15.
    Schmutzhard E, Grubwieser G, Pfausler B (1995) Liquorfiltration — eine adjuvante therapeutische Strategie bei der bakteriellen Meningitis. Neuropsychiatrie 2:104–105Google Scholar
  16. 16.
    Stadlbauer D, Pfausler B, Herold M et al (1996) Liquor cerebrospinalis Filtration reduziert TNF-alpha im Liquor bei bakterieller Meningitis. In: Treib J, Stoll M, Lindemuth R (eds) Arbeitstagung der Arbeitsgemeinschaft für Neurologische Intensivmedizin (ANIM), Verlag Conrad & Bothner, Zweibrücken, p 33 (abstract)Google Scholar
  17. 17.
    Tunkel AR, Wispelwey B, Scheld M (1990) Bacterial meningitis: recent advances in pathophysiology and treatment. Ann Intern Med 112:610–623PubMedCrossRefGoogle Scholar
  18. 18.
    Tuomanen E, Baruch A (1989) New antibodies as adjunctive therapies for gram-positive bacterial meningitis. Pediatr Infect Dis J 8:923–928PubMedCrossRefGoogle Scholar
  19. 19.
    Tuomanen E (1989) Bakterielle Meningitis und die Blut-Hirn-Schranke. Spektr Wissensch 4:86–90Google Scholar
  20. 20.
    Wollinsky KH, Hülser PJ, Brinkmeier H et al (1995) Klinische Erfahrungen mit der CSFFiltration bei Guillain-Barré-Syndrom, chronisch inflammatorischer demyelinisierender Polyneuropathie und multipler Sklerose. Neuropsychiatrie 2:95–99Google Scholar
  21. 21.
    Wollinsky KH, Weindler M, Hülser PJ et al (1994) Liquorpheresis (CSF-Filtration): An effective treatment in acute and chronic severe autoimmune polyradiculoneuritis (GuillainBarré-Syndrome). Eur Arch Psychiatry Clin Neurosci 241:73–76CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 1997

Authors and Affiliations

  • P. Kalischewski
  • D. Schneider
  • H. J. Kühn

There are no affiliations available

Personalised recommendations