Humoral Homeostasis — Role of Vascular Endothelium

  • R. J. Gryglewski
Conference paper


Humoral homeostasis as opposed to neuronal hemostasis is maintained by a network of endogenous factors which are secreted to body fluids and influence functioning of many cells and organs. These factors are hormones like adrenaline or autakoids like prostaglandins. In addition, bacterial toxins provoke cells to produce and release cytokines like interleukin-1. An old division of homeostatic mechanisms into “humoral” and “cellular” lost its severity when it became obvious that cytoadhesins, receptors for cytokines, HLA antigens or CD antigens might be viewed both as cellular (membrane bound) or humoral (soluble in body fluids) factors. This review will deal mainly with the role of nitric oxide from vascular endothelium in maintaining humoral homeostasis. In this respect the vascular endothelium fulfills metabolic and secretory functions.


Nitric Oxide Septic Shock Platelet Activate Factor Primary Pulmonary Hypertension iNOS mRNA 
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© Springer-Verlag Italia 1997

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  • R. J. Gryglewski

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