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Improving Ventilation by Reaeration of Atelectatic Regions with Perfluorocarbons

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Abstract

Patients with acute respiratory failure have a disturbed pulmonary surfactant system which causes an elevated surface tension at the air-tissue interface of the alveoli in the lung. This elevated surface tension leads to end-expiratory alveolar collapse, to atelectasis, to an increase in right-to-left shunt, and to a decrease in PaO2. Therefore, in these patients it is essential to apply a ventilatory treatment that is aimed at recruiting those collapsed alveoli and improving gas-exchange at the lowest possible airway pressures.

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References

  1. Von Neergaard K (1929) Neue Auffassungen über einen Grundbegriff der Atemmechanik. Die Retraktionskraft der Lunge, abhängig von der Oberflächenspannung in den Alveolen. Z Ges Exp Med 66:373–394

    Article  Google Scholar 

  2. Faithfull NS (1994) Mechanisms and efficacy of fluorochemical oxygen transport and delivery. Artif Cells Blood Substit Immobil Biotechnol 22(2):181–197

    Article  PubMed  CAS  Google Scholar 

  3. Shaffer TH, Wolfson MR, Greenspan J et al (1994) Perfluorochemical liquids as a respiratory medium. Artif Cells Blood Substit Immobi Biotechnol 22(2):315–326

    Article  CAS  Google Scholar 

  4. Fuhrman BP, Paczan PR, DeFrancis M (1991) Perfluorocarbon-associated gas exchange. Crit Care Med 19:712–722

    Article  PubMed  CAS  Google Scholar 

  5. Tütüncü AS, Lachmann B (1994) Perfluorocarbons as an alternative respiratory medium. In: Vincent JL (ed) Update in Intensive Care and Emergency Medicine, vol 18. Springer, Berlin Heidelberg New York, pp 549–563

    Google Scholar 

  6. Lachmann B, Verbrugge S (1996) Liquid ventilation. Current Opinion in Crit Care 2:60–66

    Article  Google Scholar 

  7. Lachmann B, Fraterman A,Verbrugge S (in press) Liquid ventilation. In: Marini JJ, Slutsky AS (eds) Physiological basis of ventilatory support. Marcel Dekker, inc., New York Basel Hong Kong

    Google Scholar 

  8. Hernan LJ, Fuhrman BP, Papo MC et al (1995) Cardiorespiratory effects of perfluorocarbon associated gas exchange at reduced oxygen concentrations. Crit Care Med 23:553–559

    Article  PubMed  CAS  Google Scholar 

  9. Tütüncü AS, Faithfull NS, Lachmann B (1993) Intratracheal perfluorocarbon administration combined with artificial ventilation in experimental respiratory distress syndrome: dose dependent improvement of gas exchange. Crit Care Med 21:962–969

    Article  PubMed  Google Scholar 

  10. Tütüncü AS, Faithfull NS, Lachmann B (1993) Comparison of ventilatory support with intratracheal perfluorocarbon administration and conventional mechanical ventilation in animals with acute respiratory failure. Am Rev Resp Dis 148:785–792

    Article  PubMed  Google Scholar 

  11. Tütüncü AS, Akpir K, Mulder P et al (1993) Intratracheal perfluorocarbon administration as an aid in the ventilatory management of respiratory distress syndrome. Anesthesiology 79: 1083–1093

    Article  PubMed  Google Scholar 

  12. Houmes RJM, Verbrugge S, Hendrik ER et al (1995) Hemodynamic effects of partial liquid ventilation with perflubron in acute lung injury. Intens Care Med 21:966–972

    Article  CAS  Google Scholar 

  13. Hernan LJ, Fuhrman BP, Kaiser RE Jr et al (1996) Perfluorcarbon-associated gas exchange in normal and acid-injured large sheep. Crit Care Med 24:475–481

    Article  PubMed  CAS  Google Scholar 

  14. Nesti FD, Fuhrman BP, Steinhorn DM et al (1994) Perfluorocarbon-associated gas exchange in gastric aspiration. Crit Care Med 22:1445–1452

    Article  PubMed  CAS  Google Scholar 

  15. Hirschl RB, Tooley R, Parent AC et al (1995) Improvement of gas exchange, pulmonary function, and lung injury with partial liquid ventilation: A study model in a setting of severe respiratory failure. Chest 108:500–508

    Article  PubMed  CAS  Google Scholar 

  16. Papo MC, Paczan PR, Furman BP et al (1996) Perfluorocarbon-associated gas exchange improves oxygenation, lung mechanics, and survival in a model of adult respiratory distress syndrome. Crit Care Med 24:466–474

    Article  PubMed  CAS  Google Scholar 

  17. Kazerooni EA, Pranikoff MD, Cascade PN et al (1996) Partial liquid ventilation with perflubron during extracorporeal life support in adults: radiographic appearance. Radiology 198:137–142

    PubMed  CAS  Google Scholar 

  18. Salman NH, Fuhrman BP, Steinhorn DM et al (1995) Prolonged studies of perfluorocarbon associated gas exchange and of the resumption of conventional mechanical ventilation. Crit Care Med 23:919–924

    Article  PubMed  CAS  Google Scholar 

  19. Tütüncü AS, Lachmann B (1995) Effects of partial liquid ventilation on gas exchange and lung mechanics in healthy animals. Appl Cardiopulm Pathophys 5(4):195–199

    Google Scholar 

  20. Tooley R, Hirschl RB, Parent A et al (1996) Total liquid ventilation with perfluorocarbons increases pulmonary end-expiratory volume and compliance in the setting of lung atelectasis. Crit Care Med 24:268–273

    Article  PubMed  CAS  Google Scholar 

  21. Tarczy-Hornoch P, Hildebrandt J, Mates EA et al (1996) Effects of exogenous surfactant on lung pressure-volume characteristics during liquid ventilation. J Appl Physiol 80(5): 1764–1771

    PubMed  CAS  Google Scholar 

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© 1997 Springer-Verlag Italia

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Böhm, S., Fraterman, A., Lachmann, B. (1997). Improving Ventilation by Reaeration of Atelectatic Regions with Perfluorocarbons. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2296-6_25

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  • DOI: https://doi.org/10.1007/978-88-470-2296-6_25

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-3-540-75032-1

  • Online ISBN: 978-88-470-2296-6

  • eBook Packages: Springer Book Archive

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