Abstract
Severe ventilation-perfusion mismatching and the development of pulmonary hypertension as a consequence of a diffuse and severe inflammation of the lung are characteristic for the acute respiratory failure (ARF) or acute respiratory distress syndrome (ARDS). The raise in pulmonary vascular resistance (PVR) is triggered by the hypoxic pulmonary vasoconstriction (HPV), a compensatory physiologic response to hypoxia. Additionally, the alteration of the vascular bed with an increase of capillary permeability and altered transcapillary filtration pressures promotes the shift of protein rich fluid to the interstitium and thus the development of high permeability pulmonary edema. An up to twofold increase in lung weight results in progressive atelectasis in the dependent parts of the lung due to increased gravitational forces. This, in combination with flooding of the alveolar space with proteinaceous fluid, decreases alveolar ventilation and promotes shunt perfusion and thereby the reduction in arterial oxygenation. The increase in intrapulmonary right to left shunt is mainly responsible for profound hypoxemia, whereas a reduction of diffusion capacity may play only a minor role.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hawkins JW, Dunn MI (1990) Primary pulmonary hypertension in adults. Clin Cardiol 13: 382–387
Melot C, Lejeune P, Leeman M et al (1989) Prostaglandin E1 in the adult respiratory distress syndrome. Benefit for pulmonary hypertension and cost for pulmonary gas exchange. Am Rev Respir Dis 139:106–110
Radermacher P, Santak B, Becker H et al (1989) Prostaglandin E1 and nitroglycerin reduce pulmonary capillary pressure but worsen ventilation-perfusion distributions in patients with adult respiratory distress syndrome. Anesthesiology 70:601–606
Dujic Z, Eterovic D, Tocilj J et al (1993) About mechanisms of prostaglandin E1 induced deterioration of pulmonary gas exchange in COPD patients. Clin Physiol 13:497–506
Rossaint R, Falke KJ, Lopez FA et al (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328:399–405
Fratacci MD, Frostell CG, Chen TY et al (1991) Inhaled nitric oxide. A selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep. Anesthesiology 75:990–999
Frostell CG, Fratacci M, Wain JC et al (1991) Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 83:2038–2047
Enson Y (1989) Pulmonary hypertension and its consequences. In: Baum GL, Wolinsky E (eds) Textbook of Pulmonary Diseases, 4th edn. Little, Brown and Company, Boston Toronto, pp 1139–1162
Higenbottam T, Cremona G (1993) Acute and chronic hypoxic pulmonary hypertension. Eur Respir J 6:1207–1212
Rizk D (1994) Primary pulmonary hypertension. West J Med 161:509–510
Higenbottam TW, Spiegelhalter D, Scott JP et al (1993) Prostacyclin (epoprostenol) and heart-lung transplantation as treatments for severe pulmonary hypertension. Br Heart J 70: 366–370
Walmrath D, Schneider T, Pilch J et al (1993) Aerosolised prostacyclin in adult respiratory distress syndrome. Lancet 342:961–962
Pappert D, Busch T, Gerlach H et al (1995) Aerosolized prostacyclin versus inhaled nitric oxide in children with severe acute respiratory distress syndrome. Anesthesiology 82: 1507–1511
Wetzel RC (1995) Aerosolized prostacyclin. In search of the ideal pulmonary vasodilator. Anesthesiology 82:1315–1317
Walmrath D, Schneider T, Pilch J et al (1995) Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis. Am J Respir Crit Care Med 151:724–730
Welte M, Zwissler B, Habazettl H et al (1993) PGI2 Aerosol versus nitric oxide for selective pulmonary vasodilation in hypoxic pulmonary vasoconstriction. Eur Surg Res 25:329–340
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Italia
About this paper
Cite this paper
Pappert, D., Max, M., Rossaint, R. (1997). Improved Perfusion Through the Aerated Part of the Lung by Prostacyclin Administration. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2296-6_24
Download citation
DOI: https://doi.org/10.1007/978-88-470-2296-6_24
Publisher Name: Springer, Milano
Print ISBN: 978-3-540-75032-1
Online ISBN: 978-88-470-2296-6
eBook Packages: Springer Book Archive