Pulmonary Dysfunction after Ischemia — Reperfusion

  • J. O. C. AulerJr.
Conference paper


Ischemia reperfusion injury comprehends a systemic response that may lead to many clinical disorders including acute respiratory distress syndrome (ARDS) and multiple organ system failure syndrome [1]. It may occur during resuscitation in hemorrhagic shock, after trauma, vascular surgery, following cardiopulmonary bypass, transplantation procedures and thrombolitic therapy for myocardial infarction or pulmonary embolism [2]. The functional integrity of the endothelium is consequently an important determinant of normal vascular responsiveness and nutritional flow regulation to the tissues. The impairment of pulmonary-endothelium-dependent relaxation, and consequently of ischemia-reperfusion injury may be responsible for the pulmonary vasomotor deregulation and oxygenation disturbances that accompany ARDS patients. Understanding the biophysiology of endothelial cells of pulmonary vascular territory is of paramount importance to understand the pathophysiology and treatment of ARDS. The technological advances in cellular and molecular biology allow us to clarify many points involved with the ischemia-reperfusion injury syndrome. One of the most useful tools in clarifying the role of the lungs in the processing of bioactive substances is the ability to isolate, characterize and cultivate endothelial cells [3].


Nitric Oxide Nitric Oxide Pulmonary Hypertension Acute Lung Injury Acute Respiratory Distress Syndrome 
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© Springer-Verlag Italia 1997

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