Abstract
The bewildering complexity of human brain, with its 1011 neurons which can be classified into about 103 different cell types, is by far the most intricate biological system ever studied. This complexity is further amplified by the thousands of interconnections, called synapses, with which each neuron is tied into its neural network. The autonomy of nerve terminals allows the independent regulation of the different synapses present in the same neuron. This property is at the origin of the selective modulation of subsets of synapses, a process that integrates neural circuits. Defects in this delicate apparatus underlie some of the most devastating diseases of the nervous system, such as myasthenia gravis, Parkinson’s disease, schizophrenia, and depression.
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References
Jacobson M (1993) Struggle for synthesis of the Neuron Theory. In: Foundations of Neuroscience, by Jacobson M, Plenum Press, New York and London, pp 151–227
Jessel TM, Kandel ER (1993) Synaptic transmission: a bidirectional and self-modifiable form of cell-cell communication. Cell 72/Neuron 10[Suppl]:l-30
Calakos N, Scheller RH (1996) Synaptic vesicle biogenesis, docking and fusion: a molecular description. Physiol Rev 76:1–29
Clements JD (1996) Transmitter time course in the synaptic cleft: its role in central synaptic function. Trends Neurosci 19:163–171
Unwin N (1993) Neurotransmitter action: opening of ligand-gated channels. Cell 72/Neuron 10[Suppl]:31–41
Hawkins RD (1996) No honey, I don’t remember. Neuron 16:465–467
Bothwell M (1995) Functional interactions of neurotrophins and neurotrophin receptors. Annu Rev Neurosci 18:223–253
Bonhoeffer T (1996) Neurotrophins and activity-dependent development of the neocortex. Curr Opin Neurobiol 6:119–126
De Camilli P, Jahn R (1990) Pathways to regulated exocytosis in neurons. Annu Rev Physiol 52:625–645
Hokfelt T (1991) Neuropeptides in perspective: the last ten years. Neuron 7:867–879
Bauerfeind R, Huttner W (1993) Biogenesis of constitutive secretory vesicles, secretory granules and synaptic vesicles. Curr Opin Cell Biol 5:628–635
Dennis-Donini S (1992) Calcitonin gene-related peptide influence on central nervous system differentiation. Annals NY Acad Sci 657:344–350
Cooke NE, Cot D, Weiner RI et al (1980) Structure of a cDNA complementary to rat prolactin messenger RNA. J Biol Chem 255:6502–6510
Tooze SA, Stinchombe JC (1992) Biogenesis of secretory granules. Seminars Cell Biol 3: 357–366
Schaefer M, Picciotto MR, Kreiner T et al (1985) Aplysia neurons express a gene encoding multiple FMRF-amide neuropeptides. Cell 41:457–467
Simon EJ, Hiller JM (1994) Opioid peptides and opioid receptors. In: Siegel GJ, Agranoff BW, Albers R et al (eds) Basic Neurochemistry, 5th edn. Raven Press, New York
Amara SG, Jones V, Rosenfeld MG et al (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298: 240–244
Nawa H, Kotani H, Nakanishi S (1984) Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing. Nature 312:729–734
Sossin WS, Fisher JM, Scheller RH (1989) Cellular and molecular biology of neuropeptide processing and packaging. Neuron 2:1407–1417
Chanat E, Huttner WB (1991) Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network. J Cell Biol 115:1505–1519
Steele PA, Costa E (1990) Opioid-like immunoreactive neurons in secretomotor pathways of the guinea pig ileum. Neuroscience 38:771–786
Iversen LL (1995) Neuropeptides: promise unfilled? Trends Neurosci 18:49–50
Thureson-Klein K (1983) Exocytosis from large and small dense cored vesicles in noradrenergic nerve terminals. Neuroscience 10:245–252
Tsukita S, Ishikawa H (1980) The movement of membraneous organelles in axons. J Cell Biol 84:513–530
Regnier-Vigouroux A, Tooze SA, Huttner WB (1991) Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane. EMBO J 10:3589–3601
Regnier-Vigouroux A, Huttner WB (1993) Biogenesis of small synaptic vesicles and synaptic-like microvesicles. Neurochem Res 18:59–64
Bennett MK, Calakos N, Kreinner T et al (1992) Synaptic vesicle membrane proteins insert to form a multimeric complex. J Cell Biol 116:761–775
Feany MB, Lee S, Edwards RH et al (1993) The synaptic vesicle proteins SV2, synaptotagmin and synaptophysin are sorted to separate cellular compartments in CHO fibroblasts. J Cell Biol 123:575–584
Pley U, Parham P (1993) Chlatrin: its role in receptor-mediated vesicular transport and specialized functions in neurons. Crit Rev Mol Biol 28:431–464
Hirokawa N (1996) Organelle transport along microtubules - the role of KIFs. Trends Cell Biol 6:135–141
Brady ST, Sperry AO (1995) Biochemical and functional diversity of microtubules motors in the nervous system. Curr Opin Neurobiol 5:551–558
Coy DL, Howard J (1994) Organelle transport and sorting in axons. Curr Opin Neurobiol 4:662–667
Kuno M (1995) How transmitter release is triggered. In: Kuno M (ed) The synapse: function, plasticity and neurotrophism. Oxford University Press Oxford New York Tokyo
Nelson N (1992) The vacuolar H+ ATPase - one of the most fundamental ion pumps in nature. J Exp Biol 172:19–27
Tabb JS, Kish PE, van Dyke R et al (1992) Glutamate transport into synaptic vesicles: roles of membrane potential, pH gradient, and intravesicular pH. J Biol Chem 267:15412–15418
Kelly RB (1993) Storage and release of neurotransmitters. Cell 72/Neuron 10[Suppl]:43–53
Ferro-Novick S, Jahn R (1994) Vesicle fusion from yeast to man. Nature 370:191–193
De Camilli P, Benfenati F, Valtorta F et al (1990) The synapsins. Annu Rev Cell Biol 6: 433–460
Sudhof TC (1995) The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375:645–653
Burns ME, Augustine GJ (1995) Synaptic structure and function: dynamic organization yelds architectural precision. Cell 83:187–194
Bennett MK, Scheller RH (1994) A molecular description of synaptic vesicle membrane trafficking. Annu Rev Biochem 63:63–100
Valtorta F, Benfenati F, Greengard P (1992) Structure and function of the synapsins. J Biol Chem 267:7195–7198
Rosahi TW, Spillane D, Missier M et al (1995) Essential functions of synapsins I and II in synaptic vesicle regulation. Nature 375:488–493
Pieribone VA, Shupliakov O, Brodin L et al (1995) Distinct pools of synaptic vesicles in neurotransmitter release. Nature 375:493–497
Di Liegro I, Savettieri G, Coppolino M et al (1995) Expression of synapsin I gene in primary cultures of differentiating rat cortical neurons. Neurochem Res 20:239–243
Zerial M (1995) Rab proteins. In: Zerial M, Huber LA (eds) Guide book to the small GTPases. Oxford University Press, Oxford, New York, Tokyo
Goda Y, Stevens CF (1994) Two components of transmitter release at a central synapse. Proc Natl Acad Sci USA 91:12942–12946
Neher E, Augustine GJ (1992) Calcium gradients and buffers in bovine chromaffin cells. J Physiol Lond 450:273–301
Dunlap K, Luebke JI, Turner TJ (1995) Exocytotic Ca2+ channels in mammalian central neurons. Trends Neurosci 18:89–98
Hayashi T, Yamasaki S, Nauenburg S et al (1995) Disassembly of the reconstituted synaptic vesicle membrane fusion complex in vitro. EMBO J 14:2317–2325
Brennwald P, Kearns B, Champion K et al (1994) Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis. Cell 79: 245–258
Harrison SK, Broadie K, Goor JVD et al (1994) Mutations in the Drosophila rop gene suggests a function in general secretion and synaptic transmission. Neuron 13:555–566
Pevsner J, Hsu SC, Braun JEA et al (1994) Specificity and regulation of a synaptic vesicle docking complex. Neuron 13:353–361
Whiteheart SW, Kubalek EW (1995) SNAPs and NSF: general members of the fusion apparatus. Trends Cell Biol 5:64–68
Zimmerberg J, Vogel SS, Chernomordik LV (1993) Mechanisms of membrane fusion. Annu Rev Biophys Biomol Struct 22:433–466
Schweizer FE, Betz H, Augustine GJ (1995) From vesicle docking to endocytosis: intermediate reactions of exocytosis. Neuron 14:689–696
Adler J, Lu B, Valtorta F et al (1992) Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: requirement for synaptophysin. Science 257:657–661
Adler J, Xie Z, Valtorta F et al (1992) Antibodies to synaptophysin interfere with transmitter secretion at the neuromuscular synapses. Neuron 9:759–768
Thomas L, Hartung K, Langosch D et al (1988) Identification of synaptophysin as a hexameric channel protein of the synaptic vesicle membrane. Science 242:1050–1053
Kumar NM, Gilula NB (1996) The gap junction communication channel. Cell 84:381–388
De Camilli P, Takei K (1996) Molecular mechanisms in synaptic vesicle endocytosis and recycling. Neuron 16:481–486
Heuser J (1989) The role of synaptic coated vesicles in recycling of synaptic vesicle membrane. Cell Biol Internatl Reports 13:1063–1076
Ye W, Ali N, Bembenek ME et al (1995) Inhibition of clatrin assembly by high affinity binding of specific inositol polyphosphates to the synapse-specific clatrin assembly protein AP-3. J Biol Chem 270:1564–1568
Thomas PA, Lee K, Wong G et al (1994) A triggered mechanism retrieves membrane in seconds after calcium-stimulated exocytosis in single pituitary cells. J Cell Biol 124:667–675.
Koenig JH, Ikeda K (1989) Disappearance and reformation of synaptic vesicle membrane upon transmitter release observed under reversible blockage of membrane retrieval. J Neurosci 9:3844–3860
Takei K, McPherson PS, Schmid SL et al (1995) Tubular membrane invaginations coated by dynamin mediate budding from internal membranes in nerve terminals. Nature 374:186–190
Ungewickel E, Ungewickel H, Holstein SEH et al (1995) Role of auxillin in uncoating clatrin-coated vesicles. Nature 378:632–635
Erulkar SD (1994) Chemically mediated synaptic transmission: an overview. In: Siegel GJ, Agranoff BW, Albers RW et al (eds) Basic Neurochemistry, 5th edn. Raven Press, New York
Riedel G (1996) Function of metabotropic glutamate receptors in learning and memory. Trends Neurosci 19:219–224
Dani JA, Mayer ML (1995) Structure and function of glutamate and nicotinic acetylcholine receptors. Curr Opin Neurobiol 5:310–317
Kuhse J, Betz H, Kirsch J (1995) The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr Opin Neurobiol 5:318–323
Hollmann M, Maron C, Heinemann S (1994) N-glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluRl. Neuron 13: 1331–1343
Seeburg PH (1993) The molecular biology of mammalian glutamate receptor channels. Trends Neurosci 16:359–365
Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17: 31–108
Jonas P, Racca C, Sakmann B et al (1994) Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential gluR-B subunit expression. Neuron 12:1281–1289
Kim U, Nishikura K (1993) Double-stranded RNA adenosine deaminase as a potential mammalian RNA editing factor. Seminars Cell Biol 4:285–293
Lomeli H, Mosbacher J, Melcher T et al (1994) Control of kinetic properties of AMPA receptor channels by nuclear RNA editing. Science 266:1709–1713
Dabiri GA, Lai F, Drakas RA, Nishikura K (1996) Editing of the GluR-B ion channel RNA in vitro by recombinant double-stranded RNA adenosine deaminase. EMBO J 15:34–45
Benne R (1996) The long and short of it. Nature 380:391–392
Brownstein MJ (1994) Neuropeptides. In: Siegel GJ, Agranoff BW, Albers R et al (eds) Basic Neurochemistry, 5th edn. Raven Press, New York
Wickman KD, Clapham DE (1995) G-protein regulation of ion channels. Curr Opin Neurobiol 5:278–285
Zimmerman AL (1995) Cyclic nucleotide gated channels. Curr Opin Neurobiol 5, 296–303
Hamm HE, Gilchrist A (1996) Heterotrimeric G proteins. Curr Opin Cell Biol 8:189–196
Clapham DE (1996) The G-protein nanomachine. Nature 379:297–299
Logothetis DE, Kurachi Y, Galper J et al (1987) The (3y subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. Nature 325:321–326
Clapham DE, Neer EJ (1993) New roles for G-protein py-dimers in transmembrane signalling. Nature 365:403–406
Schrebmayer W, Dessauer CW, Vorobiov D et al (1996) Inhibition of an inwardly rectifying K+ channel by G-protein a-subunits. Nature 380:624–627
Lefkowitz RJ (1993) G protein-coupled receptor kinases. Cell 74:409–412
Wilson CJ, Applebury ML (1993) Arresting G-protein-coupled receptor activity. Current Biol 3:683–686
Koelle MR, Horvitz HR (1996) EGL-10 regulates G protein signalling in the C.elegans nervous system and shares a conserved domain with many mammalian proteins. Cell 84: 115–125
Siderovski DP, Hessel A, Chung S et al (1996) A new family of regulators of G-protein-coupled receptors? Current Biol 6:211–212
Wan Y, Kurosaki T, Huang XY (1996) Tyrosine kinases in activation of the MAP kinase cascade by G protein-coupled receptors. Nature 380:541–544
van Corven E, Hordijk PL, Medema RH et al (1993) Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts. Proc Natl Acad Sci USA 90:1257–1261
Takata M, Sabe H, Hata A et al (1994) Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. EMBO J 13:1341–1349
van Biesen T, Hawes BE, Luttrell DK et al (1995) Receptor-tyrosine-kinase- and G(3y-mediated MAP kinase activation by a common signalling pathway. Nature 376:781–784
Karin M, Hunter T (1995) Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Current Biol 5:747–757
Cahill MA, Janknecht R, Nordheim A (1996) Signalling pathways: jack of all cascades. Current Biol 6:16–19
Ihle JN (1996) STATs and MAPKs: obligate or opportunistic partners in signalling. BioEssays 18:95–98
Chrivia JC, Kwok RP, Lamb N et al (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855–859
Saltiel AR, Decker SJ (1994) Cellular mechanisms of signal transduction for neurotrophins. BioEssays 16:405–411
Lo DC (1996) Neurotrophic factors and synaptic plasticity. Neuron 15:979–981
Songyang Z, Cantley LC (1995) Recognition and specificity in protein tyrosine kinase-mediated signalling. Trends Biochem Sci 20:470–475
Wandless TJ (1996) SH2 domains: a question of independence. Curr Biol 6:125–127
Hunter T (1995) Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signalling. Cell 80:225–236
Finkbeiner S, Greenberg ME (1996) Ca2+-dependent routes to Ras: mechanisms for neuronal survival, differentiation, and plasticity? Neuron 16:233–236
Kang H, Schuman EM (1995) Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 267:1658–1662
Weiner N, Molinoff PB (1994) Catecholamines. In: Siegel GJ, Agranoff BW, Albers R et al (eds) Basic Neurochemistry, 5th edn. Raven Press, New York
Hebb DO (1949) The organization of behavior: a neuropsychological theory. Wiley ed, New York
Sossin WS (1996) Mechanisms for the generation of synapse specificity in long-term memory: the implications of a requirement for transcription. Trends Neurosci 19:215–218
Schulman H (1995) Protein phosphorylation in neural plasticity and gene expression. Curr Opin Neurobiol 5:375–381
Bliss TVP, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31–39
Carew TJ (1996) Molecular enhancement of memory formation. Neuron 16:5–8
Quinlan E, Halpain S (1996) Postsynaptic mechanisms for bidirectional control of MAP2 phosphorylation by glutamate receptors. Neuron 16:357–368
Malenka RC (1994) Synaptic plasticity in the hippocampus: LTP and LTD. Cell 78:535–538
Neven D, Zucker RS (1996) Postsynaptic levels of [Ca2+]i needed to trigger LTD and LTP. Neuron 16:619–629
Muller U (1996) Inhibition of nitric oxide synthase impairs a distinct form of long-term memory in the honeybee, apis mellifera. Neuron 16:541–549
Yin J, Wallach JS, Del Vecchio M et al (1994) Induction of dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79:49–58
Steward O, Banker GA (1992) Getting the message from the gene to the synapse: sorting and intracellular transport of RNA in neurons. Trends Neurosci 15:180–186
Ferrandon D, Elpick L, Nusslein-Volhard C et al (1994) Staufen protein associates with the 3′-UTR of bicoid mRNA to form particle that move in a microtubule-dependent manner. Cell 79:1221–1232
Steward O (1995) Targeting of mRNAs to susynaptic microdomains in dendrites. Curr Opin Neurobiol 5:55–61
Davis KL, Kahn RS, Ko G et al (1991) Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiat 148:1474–1486
Niznik HB, Van Tol HH (1992) Dopamine receptor genes: new tool for molecular psychiatry. J Psychiatry Neurosci 17:158–190
Lindvall O, Odin P (1994) Clinical application of cell transplantation and neurotrophic factors in CNS disorders. Curr Opin Neurobiol 4:752–757
Kraus JE, McNamara JO (1995) Clinical relevance of defects in signalling pathways. Curr Opin Neurobiol 5:358–366
Keating MT, Sanguinetti MC (1996) Pathophysiology of ion channel mutations. Curr Opin Genet Dev 6:326–333
Cannon SC, Brown RH Jr, Corey DP (1991) A sodium channel defect in hyperkalemic periodic paralysis: potassium-induced failure of inactivation. Neuron 6:619–626
Fontaine B, Vale-Santos JM, Jurkat-Rott K et al (1994) Mapping of the hypokalemic periodic paralysis (HypoPP) locus to chromosome lq31–32 in three European families. Nature Genet 6:267–272
Shiang R, Ryan SG, Zhu YZ et al (1993) Mutations in the al subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia. Nature Genet 5:351–358
Rogers SW, Andrews PI, Gahring LC et al (1994) Autoantibodies to glutamate receptor GluR3 in Rasmussen’s encephalitis. Science 265:648–651
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Savettieri, G., Cestelli, A., Di Liegro, I. (1997). Biochemistry of Neurotransmission: an Update. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/978-88-470-2296-6_2
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